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学科主题: 临床医学
题名:
Macrophage polarization in the maculae of age-related macular degeneration: A pilot study
作者: Cao, Xiaoguang1,5; Shen, Defen1; Patel, Mrinali M.1,3; Tuo, Jingsheng1; Johnson, T. Mark2; Olsen, Timothy W.4; Chan, Chi-Chao1
关键词: age-related macular degeneration (AMD) ; chemokine ; choroidal neovascularization ; M1 macrophage ; M2 macrophage
刊名: PATHOLOGY INTERNATIONAL
发表日期: 2011-09-01
DOI: 10.1111/j.1440-1827.2011.02695.x
卷: 61, 期:9, 页:528-535
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: CHOROIDAL NEOVASCULARIZATION ; BRUCHS MEMBRANE ; ACTIVATION ; ANGIOGENESIS ; INFLAMMATION ; INVOLVEMENT ; EXPRESSION ; PHENOTYPE ; GROWTH ; SYSTEM
英文摘要:

Macrophages can be polarized to exhibit either proinflammatory M1 or pro-angiogenic M2 phenotypes, but have high phenotypic plasticity. This pilot study investigated macrophage polarization in the macular retina and choroid of age-related macular degeneration (AMD) and non-AMD subjects, as well as in AMD choroidal neovascular membranes (CNVM). All specimens were evaluated for routine histopathology. Quantitative real-time polymerase chain reaction for representative M1 (CXCL11) and M2 (CCL22) transcripts were performed on macular choroidal trephines (MCT) of 19 AMD and nine non-AMD eye bank eyes, on the microdissected macular retinal cells from the archived slides of five geographic atrophic AMD, five exudative/neovascular AMD, and eight normal autopsied eyes, and on microdissected inflammatory cells from two surgically removed CNVM that did not respond to anti-vascular endothelial growth factor (VEGF) therapy. High M2-chemokine transcript and a low ratio of M1 to M2 chemokine transcript were found in aging non-AMD MCT. Advanced AMD maculae had a higher M1 to M2 chemokine transcript ratio compared to normal autopsied eyes. Macrophages in the two CNVM of patients unresponsive to anti-VEGF therapy were polarized toward either M1 or M2 phenotypes. The number of M2 macrophages was increased compared to M1 macrophages in normal aging eyes. A pathological shift of macrophage polarization may play a potential role in AMD pathogenesis.

语种: 英语
项目资助者: NEI
WOS记录号: WOS:000294976700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66750
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.NEI, Immunopathol Sect, Immunol Lab, NIH, Bethesda, MD 20892 USA
2.Natl Retina Inst, Chevy Chase, MD USA
3.Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA
4.Emory Univ, Emory Eye Ctr, Atlanta, GA 30322 USA
5.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China

Recommended Citation:
Cao, Xiaoguang,Shen, Defen,Patel, Mrinali M.,et al. Macrophage polarization in the maculae of age-related macular degeneration: A pilot study[J]. PATHOLOGY INTERNATIONAL,2011,61(9):528-535.
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