IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Detection of Treponema pallidum in skin lesions of secondary syphilis and characterization of the inflammatory infiltrate
Li, WH; Zhang, JZ; Ying, C
关键词polymerase chain reaction syphilis Treponema pallidum
刊名DERMATOLOGY
2004
DOI10.1159/000076479
208期:2页:94-97
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
英文摘要

Background: Syphilis is an ancient sexually transmitted disease. However, the pathogenesis of mucocutaneous lesions of secondary syphilis is not completely understood. Methods: We analyzed the presence of Treponema pallidum in formalin-fixed, paraffin-embedded biopsy specimens from mucocutaneous lesions of secondary syphilis using highly sensitive nested polymerase chain reaction (PCR). The inflammatory infiltrates from the same specimens are also characterized using immunohistochemical methods. Results and Conclusions: Ten out of 24 (41.7%) specimens are T. pallidum positive using nested PCR, whereas none of them is T. pallidum positive using traditional silver staining. The presence of T. pallidum in the mucocutaneous lesions indicates that mucocutaneous lesions of secondary syphilis might be caused by direct T. pallidum invasion rather than by an allergic reaction. Furthermore, the majority of inflammatory infiltrating cells are CD45RO-positive T cells and CD68-positive macrophages, suggesting that cellular immunity plays an important role in the host reaction against T. pallidum infection in secondary syphilis. Copyright (C) 2004 S. Karger AG, Basel.

语种英语
WOS记录号WOS:000220585700002
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66759
Collection北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Dermatol & Venerol, Beijing 100871, Peoples R China
2.Loyola Univ, Med Ctr, Dept Pathol, Maywood, IL 60153 USA
Recommended Citation
GB/T 7714
Li, WH,Zhang, JZ,Ying, C. Detection of Treponema pallidum in skin lesions of secondary syphilis and characterization of the inflammatory infiltrate[J]. DERMATOLOGY,2004,208(2):94-97.
APA Li, WH,Zhang, JZ,&Ying, C.(2004).Detection of Treponema pallidum in skin lesions of secondary syphilis and characterization of the inflammatory infiltrate.DERMATOLOGY,208(2),94-97.
MLA Li, WH,et al."Detection of Treponema pallidum in skin lesions of secondary syphilis and characterization of the inflammatory infiltrate".DERMATOLOGY 208.2(2004):94-97.
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