北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Characterization of Community Acquired Staphylococcus aureus Associated with Skin and Soft Tissue Infection in Beijing: High Prevalence of PVL+ ST398
作者: Zhao, Chunjiang1,2; Liu, Yingmei3; Zhao, Mingze4; Liu, Yali2; Yu, Yong5; Chen, Hongbin2; Sun, Qiuning2; Chen, Huawei4; Jiang, Wei5; Liu, Yudong6; Han, Shaomei1; Xu, Yingchun2; Chen, Minjun2; Cao, Bin3; Wang, Hui1,2
刊名: PLOS ONE
发表日期: 2012-06-06
DOI: 10.1371/journal.pone.0038577
卷: 7, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: CASSETTE CHROMOSOME MEC ; METHICILLIN-RESISTANT ; CLONES ; HOSPITALS ; DISEASE ; GENOME ; GENES ; MRSA
英文摘要:

Adult community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and methicillin-susceptible S aureus (CA-MSSA) skin and soft tissue infection (SSTI) in China is not well described. A prospective cohort of adults with SSTI was established between January 2009 and August 2010 at 4 hospitals in Beijing. Susceptibility testing and molecular typing, including multilocus sequence typing, spa, agr typing, and toxin detection were assessed for all S. aureus isolates. Overall, 501 SSTI patients were enrolled. Cutaneous abscess (40.7%) was the most common infection, followed by impetigo (6.8%) and cellulitis (4.8%). S. aureus accounted for 32.7% (164/501) of SSTIs. Five isolates (5/164, 3.0%) were CA-MRSA. The most dominant ST in CA-MSSA was ST398 (17.6%). The prevalence of Panton-Valentine Leukocidin (pvl) gene was 41.5% (66/159) in MSSA. Female, younger patients and infections requiring incision or drainage were more commonly associated with pvl-positive S. aureus (P<0.03); sec gene was more often identified in CC5 (P<0.03); seh gene was more prevalent in CC1 (P = 0.001). Importantly, ST59 isolates showed more resistance to erythromycin, clindamycin and tetracycline, and needed more surgical intervention. In conclusion, CA-MRSA infections were rare among adult SSTI patients in Beijing. Six major MSSA clones were identified and associated with unique antimicrobial susceptibility, toxin profiles, and agr types. A high prevalence of livestock ST398 clone (17.1% of all S. aureus infections) was found with no apparent association to animal contact.

语种: 英语
所属项目编号: 2007-2015 ; NCET-10-0205 ; 30971571
项目资助者: Beijing Medical Scientific Development Foundation ; Programme for New Century Excellent Talents in University ; National Natural Science Foundation of China
WOS记录号: WOS:000305348400076
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66761
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Clin Lab, Peking Univ Peoples Hosp, Beijing 100871, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China
3.Capital Med Univ, Dept Infect Dis & Clin Microbiol, Beijing Chao Yang Hosp, Beijing, Peoples R China
4.Beijing Pinggu Hosp, Dept Clin Lab, Beijing, Peoples R China
5.Peoples Liberat Army Gen Hosp, Dept Clin Lab, Hosp 1, Beijing, Peoples R China
6.Univ Alabama Birmingham, Birmingham, AL USA

Recommended Citation:
Zhao, Chunjiang,Liu, Yingmei,Zhao, Mingze,et al. Characterization of Community Acquired Staphylococcus aureus Associated with Skin and Soft Tissue Infection in Beijing: High Prevalence of PVL+ ST398[J]. PLOS ONE,2012,7(6).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, Chunjiang]'s Articles
[Liu, Yingmei]'s Articles
[Zhao, Mingze]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, Chunjiang]‘s Articles
[Liu, Yingmei]‘s Articles
[Zhao, Mingze]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace