IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Characterization of Community Acquired Staphylococcus aureus Associated with Skin and Soft Tissue Infection in Beijing: High Prevalence of PVL+ ST398
Zhao, Chunjiang1,2; Liu, Yingmei3; Zhao, Mingze4; Liu, Yali2; Yu, Yong5; Chen, Hongbin2; Sun, Qiuning2; Chen, Huawei4; Jiang, Wei5; Liu, Yudong6; Han, Shaomei1; Xu, Yingchun2; Chen, Minjun2; Cao, Bin3; Wang, Hui1,2
刊名PLOS ONE
2012-06-06
DOI10.1371/journal.pone.0038577
7期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CASSETTE CHROMOSOME MEC ; METHICILLIN-RESISTANT ; CLONES ; HOSPITALS ; DISEASE ; GENOME ; GENES ; MRSA
英文摘要

Adult community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and methicillin-susceptible S aureus (CA-MSSA) skin and soft tissue infection (SSTI) in China is not well described. A prospective cohort of adults with SSTI was established between January 2009 and August 2010 at 4 hospitals in Beijing. Susceptibility testing and molecular typing, including multilocus sequence typing, spa, agr typing, and toxin detection were assessed for all S. aureus isolates. Overall, 501 SSTI patients were enrolled. Cutaneous abscess (40.7%) was the most common infection, followed by impetigo (6.8%) and cellulitis (4.8%). S. aureus accounted for 32.7% (164/501) of SSTIs. Five isolates (5/164, 3.0%) were CA-MRSA. The most dominant ST in CA-MSSA was ST398 (17.6%). The prevalence of Panton-Valentine Leukocidin (pvl) gene was 41.5% (66/159) in MSSA. Female, younger patients and infections requiring incision or drainage were more commonly associated with pvl-positive S. aureus (P<0.03); sec gene was more often identified in CC5 (P<0.03); seh gene was more prevalent in CC1 (P = 0.001). Importantly, ST59 isolates showed more resistance to erythromycin, clindamycin and tetracycline, and needed more surgical intervention. In conclusion, CA-MRSA infections were rare among adult SSTI patients in Beijing. Six major MSSA clones were identified and associated with unique antimicrobial susceptibility, toxin profiles, and agr types. A high prevalence of livestock ST398 clone (17.1% of all S. aureus infections) was found with no apparent association to animal contact.

语种英语
WOS记录号WOS:000305348400076
项目编号2007-2015 ; NCET-10-0205 ; 30971571
资助机构Beijing Medical Scientific Development Foundation ; Programme for New Century Excellent Talents in University ; National Natural Science Foundation of China
引用统计
被引频次:57[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66761
专题北京大学第二临床医学院
作者单位1.Peking Univ, Dept Clin Lab, Peking Univ Peoples Hosp, Beijing 100871, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China
3.Capital Med Univ, Dept Infect Dis & Clin Microbiol, Beijing Chao Yang Hosp, Beijing, Peoples R China
4.Beijing Pinggu Hosp, Dept Clin Lab, Beijing, Peoples R China
5.Peoples Liberat Army Gen Hosp, Dept Clin Lab, Hosp 1, Beijing, Peoples R China
6.Univ Alabama Birmingham, Birmingham, AL USA
推荐引用方式
GB/T 7714
Zhao, Chunjiang,Liu, Yingmei,Zhao, Mingze,et al. Characterization of Community Acquired Staphylococcus aureus Associated with Skin and Soft Tissue Infection in Beijing: High Prevalence of PVL+ ST398[J]. PLOS ONE,2012,7(6).
APA Zhao, Chunjiang.,Liu, Yingmei.,Zhao, Mingze.,Liu, Yali.,Yu, Yong.,...&Wang, Hui.(2012).Characterization of Community Acquired Staphylococcus aureus Associated with Skin and Soft Tissue Infection in Beijing: High Prevalence of PVL+ ST398.PLOS ONE,7(6).
MLA Zhao, Chunjiang,et al."Characterization of Community Acquired Staphylococcus aureus Associated with Skin and Soft Tissue Infection in Beijing: High Prevalence of PVL+ ST398".PLOS ONE 7.6(2012).
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