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学科主题: 临床医学
题名:
Prognosis of patients with gastric cancer and solitary lymph node metastasis
作者: Chen, Chun-Qiu1; Wu, Xiao-Jiang2; Yu, Zhen1; Bu, Zhao-De2; Zuo, Ke-Qiang1; Li, Zi-Yu2; Ji, Jia-Fu2
关键词: Gastric cancer ; Solitary lymph node metastasis ; Age ; Metastatic lymph node ratio ; Survival
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2013-12-14
DOI: 10.3748/wjg.v19.i46.8611
卷: 19, 期:46, 页:8611-8618
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: CLINICOPATHOLOGICAL CHARACTERISTICS ; OLDER PATIENTS ; CURATIVE RESECTION ; N RATIO ; YOUNG ; SURVIVAL ; CARCINOMA ; NUMBER ; RECURRENCE ; ADENOCARCINOMA
英文摘要:

AIM: To investigate the relationship of solitary lymph node metastasis (SLNM) and age with patient survival in gastric cancer (GC).

METHODS: The medical records databases of China′s Beijing Cancer Hospital at the Peking University School of Oncology and Shanghai Tenth People′s Hospital affiliated to Tongji University were searched retrospectively to identify patients with histologically proven GC and SLNM who underwent surgical resection between October 2003 and December 2012. Patients with distant metastasis or gastric stump carcinoma following resection for benign disease were excluded from the analysis. In total, 936 patients with GC + SLNM were selected for analysis and the recorded parameters of clinicopathological disease and follow-up (range: 13-2925 d) were collected. The Kaplan-Meier method was used to stratify patients by age (<= 50 years-old, n = 198; 50-64 years-old, n = 321; = 65 years-old, n = 446) and by metastatic lymph node ratio [MLR < 0.04 (1/25), n = 180; 0.04-0.06 (1/25-1/15), n = 687; = 0.06 (1/15), n = 98] for 5-year survival analysis. The significance of intergroup differences between the survival curves was assessed by a log-rank test.

RESULTS: The 5-year survival rate of the entire GC + SLNM patient population was 49.9%. Stratification analysis showed significant differences in survival time (post-operative days) according to age: = 50 years-old: 950.7 +/- 79.0 vs 50-64 years-old: 1697.8 +/- 65.9 vs = 65 years-old: 1996.2 +/- 57.6, all P < 0.05. In addition, younger age (= 50 years-old) correlated significantly with mean survival time (r = 0.367, P < 0.001). Stratification analysis also indicated an inverse relationship between increasing MLR and shorter survival time: < 0.04: 52.8% and 0.04-0.06: 51.1% vs = 0.06: 40.5%, P < 0.05. The patients with the shortest survival times and rates were younger and had a high MLR (= 0.06): = 50 years-old: 496.4 +/- 133.0 and 0.0% vs 50-65 years-old: 1180.9 +/- 201.8 and 21.4% vs = 65 years-old: 1538.4 +/- 72.4 and 37.3%, all P < 0.05. The same significant trend in shorter survival times and rates for younger patients was seen with the mid-range MLR group (0.04-0.06), but the difference between the two older groups was not significant. No significant differences were found between the age groups of patients with MLR < 0.04. Assessment of clinicopathological parameters identified age group, Borrmann type, histological type and tumor depth as the most important predictors of the survival rates and times observed for this study population.

CONCLUSION: GC patients below 51 years of age with MLR of SLNM above 0.06 have shorter life expectancy than their older counterparts. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.

语种: 英语
所属项目编号: 81170345 ; 12HBBD110
项目资助者: National Science Foundation of China ; Shanghai Tenth People&prime ; s Hospital Project for Cultivating Tutors of Doctors
WOS记录号: WOS:000329129200016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66762
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Tongji Univ, Peoples Hosp Shanghai 10, Dept Gen Surg, Shanghai 200072, Peoples R China
2.Peking Univ, Beijing Canc Hosp, Sch Oncol, Dept Surg, Beijing 100036, Peoples R China

Recommended Citation:
Chen, Chun-Qiu,Wu, Xiao-Jiang,Yu, Zhen,et al. Prognosis of patients with gastric cancer and solitary lymph node metastasis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2013,19(46):8611-8618.
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