北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase
作者: Sun, Zhongcui1,2; Zhang, Ji2; Zhang, Jifeng3; Chen, Chunlei2; Du, Quan2; Chang, Lin3; Cao, Chunmei2; Zheng, Ming2; Garcia-Barrio, Minerva T.4; Chen, Yuqing E.3; Xiao, Rui-Ping2; Mao, Jieming1; Zhu, Xiaojun2
关键词: Rad GTPase ; Cardiomyocyte ; Apoptosis ; p38 MAPK ; Bcl-x(L)
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2011-05-27
DOI: 10.1016/j.bbrc.2011.04.104
卷: 409, 期:1, 页:52-57
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: MITOCHONDRIAL DEATH PATHWAY ; CARDIAC MYOCYTE APOPTOSIS ; MYOCARDIAL-INFARCTION ; BINDING PROTEINS ; RHO-KINASE ; MUSCLE ; HEART ; FAMILY ; CELLS ; LEADS
英文摘要:

Rad is a member of a subclass of small GTP-binding proteins, the RGK family. In the present study we investigated the role of Rad protein in regulating cardiomyocyte viability. DNA fragmentation and TUNEL assays demonstrated that Rad promoted rat neonatal cardiomyocyte apoptosis. Rad silencing fully blocked serum deprivation induced apoptosis, indicating Rad is necessary for trigger cardiomyocyte apoptosis. Rad overexpression caused a dramatic decrease of the anti-apoptotic molecule Bcl-x(L), whereas Bcl-x(L) overexpression protected cardiomyocytes against Rad-induced apoptosis. Rad-triggered apoptosis was mediated by the activation of p38 MAPK. The p38 blocker SB203580 effectively protected cardiomyocytes against Rad-evoked apoptosis. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30400223 ; 30671027 ; 2007CB512100 ; 2010CB529503 ; 0835237N ; 0625705Z
项目资助者: Peking University ; Natural Science Foundation of China ; National Basic Research Program of China ; American Heart Association ; Midwest Affiliate Fellowship
WOS记录号: WOS:000291380100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66763
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
2.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
3.Univ Michigan, Ctr Cardiovasc, Ann Arbor, MI 48109 USA
4.Morehouse Sch Med, Cardiovasc Res Inst, Atlanta, GA 30310 USA

Recommended Citation:
Sun, Zhongcui,Zhang, Ji,Zhang, Jifeng,et al. Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,409(1):52-57.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Sun, Zhongcui]'s Articles
[Zhang, Ji]'s Articles
[Zhang, Jifeng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Sun, Zhongcui]‘s Articles
[Zhang, Ji]‘s Articles
[Zhang, Jifeng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace