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学科主题临床医学
Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase
Sun, Zhongcui1,2; Zhang, Ji2; Zhang, Jifeng3; Chen, Chunlei2; Du, Quan2; Chang, Lin3; Cao, Chunmei2; Zheng, Ming2; Garcia-Barrio, Minerva T.4; Chen, Yuqing E.3; Xiao, Rui-Ping2; Mao, Jieming1; Zhu, Xiaojun2
关键词Rad GTPase Cardiomyocyte Apoptosis p38 MAPK Bcl-x(L)
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2011-05-27
DOI10.1016/j.bbrc.2011.04.104
409期:1页:52-57
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]MITOCHONDRIAL DEATH PATHWAY ; CARDIAC MYOCYTE APOPTOSIS ; MYOCARDIAL-INFARCTION ; BINDING PROTEINS ; RHO-KINASE ; MUSCLE ; HEART ; FAMILY ; CELLS ; LEADS
英文摘要

Rad is a member of a subclass of small GTP-binding proteins, the RGK family. In the present study we investigated the role of Rad protein in regulating cardiomyocyte viability. DNA fragmentation and TUNEL assays demonstrated that Rad promoted rat neonatal cardiomyocyte apoptosis. Rad silencing fully blocked serum deprivation induced apoptosis, indicating Rad is necessary for trigger cardiomyocyte apoptosis. Rad overexpression caused a dramatic decrease of the anti-apoptotic molecule Bcl-x(L), whereas Bcl-x(L) overexpression protected cardiomyocytes against Rad-induced apoptosis. Rad-triggered apoptosis was mediated by the activation of p38 MAPK. The p38 blocker SB203580 effectively protected cardiomyocytes against Rad-evoked apoptosis. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000291380100009
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66763
专题北京大学第三临床医学院_心血管内科
北京大学基础医学院
北京大学药学院
北京大学临床肿瘤学院_肝胆胰外二科
作者单位1.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
2.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
3.Univ Michigan, Ctr Cardiovasc, Ann Arbor, MI 48109 USA
4.Morehouse Sch Med, Cardiovasc Res Inst, Atlanta, GA 30310 USA
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Sun, Zhongcui,Zhang, Ji,Zhang, Jifeng,et al. Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,409(1):52-57.
APA Sun, Zhongcui.,Zhang, Ji.,Zhang, Jifeng.,Chen, Chunlei.,Du, Quan.,...&Zhu, Xiaojun.(2011).Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,409(1),52-57.
MLA Sun, Zhongcui,et al."Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 409.1(2011):52-57.
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