IR@PKUHSC  > 北京大学临床肿瘤学院  > 胸部肿瘤内科
学科主题临床医学
PIK3CA mutation in Chinese patients with lung squamous cell carcinoma
Yu, Jinglin; Bai, Hua; Wang, Zhijie; Wei, Zhigang; Ding, Xiaosheng; Duan, Jianchun; Yang, Lu; Wu, Meina; Wang, Yuyan; Wang, Jie
关键词Lung squamous cell carcinoma (LSCC) PIK3CA mutation EGFR mutation KRAS mutation
刊名CHINESE JOURNAL OF CANCER RESEARCH
2013-08-01
DOI10.3978/j.issn.1000-9604.2013.08.03
25期:4页:416-422
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Sciences Foundation Distinguished Young Scholars ; National Natural Sciences Foundation General Program ; Capital Development Foundation ; Beijing Health Systems Academic Leader ; Science and Technology Project of Beijing ; National Natural Sciences Foundation Distinguished Young Scholars ; National Natural Sciences Foundation General Program ; Capital Development Foundation ; Beijing Health Systems Academic Leader ; Science and Technology Project of Beijing
研究领域[WOS]Oncology
关键词[WOS]GROWTH-FACTOR RECEPTOR ; HIGH-FREQUENCY ; HUMAN CANCERS ; GENE ; CHEMOTHERAPY ; GEFITINIB ; ERLOTINIB ; SURVIVAL ; RAS
英文摘要

Objective: To investigate PIK3CA mutation in Chinese patients with lung squamous cell carcinoma (LSCC) and explore their relationship with clinicopathological profiles.

Methods: Tumor samples from 123 cases of LSCC were included in this study. PIK3CA mutations in exon 9 and 20 were screened by pyrosequencing and confirmed by clone sequencing or amplification refractory mutation system (ARMS). Denaturing performance liquid chromatography (DHPLC) was employed for evaluation of EGFR mutation in exon 19, 21 and KRAS mutation.

Results: PIK3CA mutations were found in 3 (2.4%) patients. The mutation type included E545K, E452Q and H1047R. Of these three patients, one coupled with EGFR mutation, and the other two coupled with PIK3CA amplification. All the three patients shared the same clinicopathologic characteristics: male, less than 60 years old, had smoke history, stage III and carried wild-type KRAS.

Conclusions: The frequency of PIK3CA mutation is low in Chinese patients with LSCC. The mutational status of PIK3CA is not mutually exclusive to EGFR mutation.

语种英语
所属项目编号81025012 ; 81172235 ; 2007-1023 ; 2011-2-22 ; Z090507017709015
资助者National Natural Sciences Foundation Distinguished Young Scholars ; National Natural Sciences Foundation General Program ; Capital Development Foundation ; Beijing Health Systems Academic Leader ; Science and Technology Project of Beijing ; National Natural Sciences Foundation Distinguished Young Scholars ; National Natural Sciences Foundation General Program ; Capital Development Foundation ; Beijing Health Systems Academic Leader ; Science and Technology Project of Beijing
WOS记录号WOS:000324003700007
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66765
专题北京大学临床肿瘤学院_胸部肿瘤内科
作者单位Peking Univ, Canc Hosp & Inst, Dept Thorac Med Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Yu, Jinglin,Bai, Hua,Wang, Zhijie,et al. PIK3CA mutation in Chinese patients with lung squamous cell carcinoma[J]. CHINESE JOURNAL OF CANCER RESEARCH,2013,25(4):416-422.
APA Yu, Jinglin.,Bai, Hua.,Wang, Zhijie.,Wei, Zhigang.,Ding, Xiaosheng.,...&Wang, Jie.(2013).PIK3CA mutation in Chinese patients with lung squamous cell carcinoma.CHINESE JOURNAL OF CANCER RESEARCH,25(4),416-422.
MLA Yu, Jinglin,et al."PIK3CA mutation in Chinese patients with lung squamous cell carcinoma".CHINESE JOURNAL OF CANCER RESEARCH 25.4(2013):416-422.
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