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Imaging integrin alpha(v)beta(3) positive glioma with a novel RGD dimer probe and the impact of antiangiogenic agent (Endostar) on its tumor uptake
Wu, Hua1; Chen, Haojun1; Sun, Yonghong1; Wan, Ying2; Wang, Fan3; Jia, Bing3; Su, Xinhui1
关键词Integrin alpha(v)beta(3) Imaging probe Glioma Antiangiogenic therapy Endostar
刊名CANCER LETTERS
2013-07-10
DOI10.1016/j.canlet.2013.01.053
335期:1页:75-80
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者Major Projects of Fujian Province Natural Science Foundation ; National Nature Science Foundation of China ; Major Projects of Fujian Province Natural Science Foundation ; National Nature Science Foundation of China
研究领域[WOS]Oncology
关键词[WOS]RECOMBINANT HUMAN ENDOSTATIN ; HUMAN BREAST-CANCER ; IN-VIVO ; ENDOTHELIAL-CELLS ; ANGIOGENESIS ; EXPRESSION ; PEPTIDES ; ULTRASOUND ; DISEASE ; PET
英文摘要

Integrin alpha(v)beta(3) has been recognized to play an important role in angiogenesis, tumor growth and metastasis. It will be of interest to apply this promising target for tumor imaging and visualization of tumor angiogenesis in vivo. In this study, a novel integrin alpha(v)beta(3) targetting imaging probe, Tc-99m-HYNIC-E[c(RGDfK)](2), was used to investigate the glioma uptake in vitro and in vivo before and after treatment with an antiangiogenic agent, endostar. The results indicated that U87MG glioma cells have high expression of integrin alpha(v)beta(3) and special uptake of Tc-99m-HYNIC-E[c(RGDfK)](2) both in cell line and in tumor xenograft. The endostatin analogue endostar can inhibit the expression of integrin alpha(v)beta(3) receptors in both U87MG cells in vitro and glioma tissues, which suggested that integrin pathway may play a role in antiangiogenic effect of Endostar. Tc-99m-HYNIC-E[c(RGDfK)](2) may be a promising molecular imaging probe for integrin alpha(v)beta(3) positive tumor imaging and open up the possibility to establish an molecular imaging modality for assessment of tomor antiangiogenic therapy. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号2008-59-11 ; 81101066
资助者Major Projects of Fujian Province Natural Science Foundation ; National Nature Science Foundation of China ; Major Projects of Fujian Province Natural Science Foundation ; National Nature Science Foundation of China
WOS记录号WOS:000323853200010
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66768
专题北京大学医药卫生分析中心
作者单位1.Xiamen Univ, Affiliated Hosp 1, Xiamen Canc Ctr, Dept Nucl Med, Xiamen 361003, Peoples R China
2.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wu, Hua,Chen, Haojun,Sun, Yonghong,et al. Imaging integrin alpha(v)beta(3) positive glioma with a novel RGD dimer probe and the impact of antiangiogenic agent (Endostar) on its tumor uptake[J]. CANCER LETTERS,2013,335(1):75-80.
APA Wu, Hua.,Chen, Haojun.,Sun, Yonghong.,Wan, Ying.,Wang, Fan.,...&Su, Xinhui.(2013).Imaging integrin alpha(v)beta(3) positive glioma with a novel RGD dimer probe and the impact of antiangiogenic agent (Endostar) on its tumor uptake.CANCER LETTERS,335(1),75-80.
MLA Wu, Hua,et al."Imaging integrin alpha(v)beta(3) positive glioma with a novel RGD dimer probe and the impact of antiangiogenic agent (Endostar) on its tumor uptake".CANCER LETTERS 335.1(2013):75-80.
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