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Significant association between lower pulse pressure and increasing levels of a novel type of phospholipid
Yao, C. S.1; Wu, Q. Z.2; Xu, H. X.3; Liu, F.4; Chang, L. G.3; Song, L. C.3; Gao, L. S.5; Meng, X. L.1
关键词Hypertension Lysophosphatidic acid Pulse pressure Ischemia Novel phospholipid (AP)
刊名GENETICS AND MOLECULAR RESEARCH
2014
DOI10.4238/2014.February.21.16
13期:2页:2922-2930
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
资助者First Affiliated Hospital of Chinese Army General Hospital ; First Affiliated Hospital of Chinese Army General Hospital
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]LYSOPHOSPHATIDIC ACID ; PLATELET ACTIVATION ; ARTERIAL STIFFNESS ; OXIDATIVE STRESS ; HEART-FAILURE ; PC12 CELLS ; HYPERTENSION ; PREDICTOR ; RISK ; INVOLVEMENT
英文摘要

The aim of this study was to analyze the association between pulse pressure and a novel type of phospholipid with solubility similar to that of lysophosphatidic acid (LPA), designated as AP, which was reported to be elevated during ischemia. In this cross-sectional study, 416 hypertensive patients and 252 controls aged between 35 and 70 years were enrolled consecutively. Fasting blood samples were extracted for assays of phospholipids and other biomarkers. Compared to controls, the hypertensive patients had higher levels of both LPA [odds ratio (OR) = 3.83] and AP (OR = 4.30). Changes in blood pressure did not affect the levels of LPA or AP. However AP, but not LPA, levels were significantly higher in patients with lower or higher pulse pressure (Pearson chi(2) = 11.239, P = 0.001). For patients whose pulse pressure was <= 60 mmHg, plasma levels of AP were significantly negatively correlated with pulse pressure. However, this was not observed for LPA and nine other biomarkers, including lipoproteins. Plasma levels of AP increased in hypertensive patients with higher or lower pulse pressure. Thus, attention should be paid to the possibility of cerebral ischemia in hypertensive patients when they have abnormal pulse pressure, especially for those with relatively low pulse pressure.

语种英语
所属项目编号YJ2009330
资助者First Affiliated Hospital of Chinese Army General Hospital ; First Affiliated Hospital of Chinese Army General Hospital
WOS记录号WOS:000336729500061
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66770
专题北京大学第一临床医学院_神经内科
作者单位1.Chinese Army Gen Hosp, Affiliated Hosp 1, Dept Neurol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Neurol, Beijing 100871, Peoples R China
3.Third Hosp Liao Cheng City, Dept Neurol, Liaocheng, Shandong, Peoples R China
4.Peoples Hosp Rui Cheng Cty, Dept Neurol, Yucheng, Shan Xi Provinc, Peoples R China
5.8th Hosp Shi Jia Zhuang City, Dept Internal Med, Shijiazhuang, Peoples R China
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GB/T 7714
Yao, C. S.,Wu, Q. Z.,Xu, H. X.,et al. Significant association between lower pulse pressure and increasing levels of a novel type of phospholipid[J]. GENETICS AND MOLECULAR RESEARCH,2014,13(2):2922-2930.
APA Yao, C. S..,Wu, Q. Z..,Xu, H. X..,Liu, F..,Chang, L. G..,...&Meng, X. L..(2014).Significant association between lower pulse pressure and increasing levels of a novel type of phospholipid.GENETICS AND MOLECULAR RESEARCH,13(2),2922-2930.
MLA Yao, C. S.,et al."Significant association between lower pulse pressure and increasing levels of a novel type of phospholipid".GENETICS AND MOLECULAR RESEARCH 13.2(2014):2922-2930.
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