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Correlation of Diffusion-Weighted Imaging Data With Apoptotic and Proliferation Indexes in CT26 Colorectal Tumor Homografts in Balb/c Mouse
Zhang, Xiao-Yan1; Sun, Ying-Shi1; Tang, Lei1; Xue, Wei-Cheng2; Zhang, Xiao-Peng1
关键词ADC apoptosis proliferation animal
刊名JOURNAL OF MAGNETIC RESONANCE IMAGING
2011-05-01
DOI10.1002/jmri.22558
33期:5页:1171-1176
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]HIGH-B-VALUE ; POSITRON-EMISSION-TOMOGRAPHY ; TREATMENT RESPONSE ; RADIATION-THERAPY ; RECTAL-CARCINOMA ; BREAST-CANCER ; BRAIN-TUMORS ; IN-VIVO ; COEFFICIENT ; MRI
英文摘要

Purpose: To investigate whether the percentage of apparent diffusion coefficient (ADC) changes could be used as an imaging marker related to tumor cell apoptotic and Ki-67 proliferation index of tumors.

Materials and Methods: Mice bearing CT26 colorectal carcinoma tumors were scanned before radiotherapy, then divided into radiotherapy (n = 24) and control groups (n = 24). Diffusion-weighted imaging (DWI) and anatomic T2WI were performed on six randomly chosen mice in total from two groups at different timepoints after radiotherapy (4, 8, 12 hours, 1, 2, 3, 5, 7 days). After imaging, six animals were sacrificed at each timepoint and histological analyses were undertaken. ADC maps were calculated on a pixel-by-pixel basis using built-in software (Functool, GE). Regions of interest were manually circumscribed for all high-signal areas on lesions observed during DWI. The percentage of ADC changes were calculated at predefined timepoints and compared with the apoptotic and proliferation index from the histological analyses by using the Pearson correlation test.

Results: A significant positive correlation was found between the percentage of ADC changes of the viable tissue and apoptotic index. A significant negative correlation was found between the percentage of ADC changes of the viable tissue and Ki-67 proliferation index.

Conclusion: Our results suggest that the percentage of ADC changes can be used as a measurement of cell apoptotic and proliferation index in colorectal carcinoma.

语种英语
WOS记录号WOS:000289999700021
项目编号2006CB705706
资助机构National Basic Research Program of China (973 Program)
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66776
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_医学影像科
北京大学临床肿瘤学院_病理科
作者单位1.Peking Univ, Dept Radiol, Key Lab Carcinogenesis & Translat Res, Minist Educ,Canc Hosp & Inst, Beijing 100871, Peoples R China
2.Peking Univ, Dept Pathol, Canc Hosp & Inst, Beijing 100871, Peoples R China
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GB/T 7714
Zhang, Xiao-Yan,Sun, Ying-Shi,Tang, Lei,et al. Correlation of Diffusion-Weighted Imaging Data With Apoptotic and Proliferation Indexes in CT26 Colorectal Tumor Homografts in Balb/c Mouse[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2011,33(5):1171-1176.
APA Zhang, Xiao-Yan,Sun, Ying-Shi,Tang, Lei,Xue, Wei-Cheng,&Zhang, Xiao-Peng.(2011).Correlation of Diffusion-Weighted Imaging Data With Apoptotic and Proliferation Indexes in CT26 Colorectal Tumor Homografts in Balb/c Mouse.JOURNAL OF MAGNETIC RESONANCE IMAGING,33(5),1171-1176.
MLA Zhang, Xiao-Yan,et al."Correlation of Diffusion-Weighted Imaging Data With Apoptotic and Proliferation Indexes in CT26 Colorectal Tumor Homografts in Balb/c Mouse".JOURNAL OF MAGNETIC RESONANCE IMAGING 33.5(2011):1171-1176.
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