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学科主题: 临床医学
题名:
Correlation of Diffusion-Weighted Imaging Data With Apoptotic and Proliferation Indexes in CT26 Colorectal Tumor Homografts in Balb/c Mouse
作者: Zhang, Xiao-Yan1; Sun, Ying-Shi1; Tang, Lei1; Xue, Wei-Cheng2; Zhang, Xiao-Peng1
关键词: ADC ; apoptosis ; proliferation ; animal
刊名: JOURNAL OF MAGNETIC RESONANCE IMAGING
发表日期: 2011-05-01
DOI: 10.1002/jmri.22558
卷: 33, 期:5, 页:1171-1176
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: HIGH-B-VALUE ; POSITRON-EMISSION-TOMOGRAPHY ; TREATMENT RESPONSE ; RADIATION-THERAPY ; RECTAL-CARCINOMA ; BREAST-CANCER ; BRAIN-TUMORS ; IN-VIVO ; COEFFICIENT ; MRI
英文摘要:

Purpose: To investigate whether the percentage of apparent diffusion coefficient (ADC) changes could be used as an imaging marker related to tumor cell apoptotic and Ki-67 proliferation index of tumors.

Materials and Methods: Mice bearing CT26 colorectal carcinoma tumors were scanned before radiotherapy, then divided into radiotherapy (n = 24) and control groups (n = 24). Diffusion-weighted imaging (DWI) and anatomic T2WI were performed on six randomly chosen mice in total from two groups at different timepoints after radiotherapy (4, 8, 12 hours, 1, 2, 3, 5, 7 days). After imaging, six animals were sacrificed at each timepoint and histological analyses were undertaken. ADC maps were calculated on a pixel-by-pixel basis using built-in software (Functool, GE). Regions of interest were manually circumscribed for all high-signal areas on lesions observed during DWI. The percentage of ADC changes were calculated at predefined timepoints and compared with the apoptotic and proliferation index from the histological analyses by using the Pearson correlation test.

Results: A significant positive correlation was found between the percentage of ADC changes of the viable tissue and apoptotic index. A significant negative correlation was found between the percentage of ADC changes of the viable tissue and Ki-67 proliferation index.

Conclusion: Our results suggest that the percentage of ADC changes can be used as a measurement of cell apoptotic and proliferation index in colorectal carcinoma.

语种: 英语
所属项目编号: 2006CB705706
项目资助者: National Basic Research Program of China (973 Program)
WOS记录号: WOS:000289999700021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66776
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Dept Radiol, Key Lab Carcinogenesis & Translat Res, Minist Educ,Canc Hosp & Inst, Beijing 100871, Peoples R China
2.Peking Univ, Dept Pathol, Canc Hosp & Inst, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Xiao-Yan,Sun, Ying-Shi,Tang, Lei,et al. Correlation of Diffusion-Weighted Imaging Data With Apoptotic and Proliferation Indexes in CT26 Colorectal Tumor Homografts in Balb/c Mouse[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2011,33(5):1171-1176.
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