北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 遗传学研究室  > 期刊论文
学科主题: 临床医学
题名:
Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium
作者: Zhou, XB; Guo, M; Quan, LP; Zhang, W; Lu, ZM; Wang, QH; Ke, Y; Xu, NZ
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2003-06-01
卷: 9, 期:6, 页:1170-1173
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: POLYMERASE-CHAIN-REACTION ; HIGH-INCIDENCE AREA ; GENOMIC INSTABILITY ; HPV DNA ; CANCER ; INFECTION ; TYPE-16 ; ASSOCIATION ; LESIONS ; RISK
英文摘要:

AIM: To investigate the putative role of human papillomavirus (HPV) infection in the carcinogenesis of esophageal squamous cell carcinoma in China.

METHODS: Twenty-three esophageal squamous cell carcinoma samples and the distal normal epithelium from Shanxi Province, and 25 more esophageal squamous cell carcinoma samples from Anyang city, two areas with a high incidence of esophageal cancer in China, were detected for the existence of HPV-16 DNA by PCR, mRNA in situ hybridization (ISH) and immunohistochemistry (IHC) targeting HPV-16 E6 gene.

RESULTS: There were approximately 64% (31/48) patients having HPV-16 DNA in tumor samples, among them nearly two-thirds (19/31) samples were detected with mRNA expression of HPV-16 E6. However, in the normal esophageal epithelium from cancer patients, the DNA and mRNA of HPV-16 were found with much less rate: 34.7% (8/23) and 26.1% (6/23) respectively. In addition, at protein level detected by IHC assay, 27.1% (13/48) tumor samples had virus oncoprotein E6 expression, while only one case of normal epithelium was found positive.

CONCLUSION: HPV infection, especially type 16, should be considered as a risk factor for esophageal malignancies in China.

语种: 英语
WOS记录号: WOS:000183763000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66782
Appears in Collections:北京大学临床肿瘤学院_遗传学研究室_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Med Sci, Canc Inst & Canc Hosp, Lab Cell & Mol Biol, Beijing 100021, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Genet Lab, Beijing 100034, Peoples R China
3.Third Peoples Hosp Shanxi Prov, Dept Pathol, Taiyuan 030013, Peoples R China

Recommended Citation:
Zhou, XB,Guo, M,Quan, LP,et al. Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2003,9(6):1170-1173.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhou, XB]'s Articles
[Guo, M]'s Articles
[Quan, LP]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhou, XB]‘s Articles
[Guo, M]‘s Articles
[Quan, LP]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace