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Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium
Zhou, XB; Guo, M; Quan, LP; Zhang, W; Lu, ZM; Wang, QH; Ke, Y; Xu, NZ
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2003-06-01
9期:6页:1170-1173
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]POLYMERASE-CHAIN-REACTION ; HIGH-INCIDENCE AREA ; GENOMIC INSTABILITY ; HPV DNA ; CANCER ; INFECTION ; TYPE-16 ; ASSOCIATION ; LESIONS ; RISK
英文摘要

AIM: To investigate the putative role of human papillomavirus (HPV) infection in the carcinogenesis of esophageal squamous cell carcinoma in China.

METHODS: Twenty-three esophageal squamous cell carcinoma samples and the distal normal epithelium from Shanxi Province, and 25 more esophageal squamous cell carcinoma samples from Anyang city, two areas with a high incidence of esophageal cancer in China, were detected for the existence of HPV-16 DNA by PCR, mRNA in situ hybridization (ISH) and immunohistochemistry (IHC) targeting HPV-16 E6 gene.

RESULTS: There were approximately 64% (31/48) patients having HPV-16 DNA in tumor samples, among them nearly two-thirds (19/31) samples were detected with mRNA expression of HPV-16 E6. However, in the normal esophageal epithelium from cancer patients, the DNA and mRNA of HPV-16 were found with much less rate: 34.7% (8/23) and 26.1% (6/23) respectively. In addition, at protein level detected by IHC assay, 27.1% (13/48) tumor samples had virus oncoprotein E6 expression, while only one case of normal epithelium was found positive.

CONCLUSION: HPV infection, especially type 16, should be considered as a risk factor for esophageal malignancies in China.

语种英语
WOS记录号WOS:000183763000006
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66782
专题北京大学临床肿瘤学院_遗传学研究室
作者单位1.Chinese Acad Med Sci, Canc Inst & Canc Hosp, Lab Cell & Mol Biol, Beijing 100021, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Genet Lab, Beijing 100034, Peoples R China
3.Third Peoples Hosp Shanxi Prov, Dept Pathol, Taiyuan 030013, Peoples R China
推荐引用方式
GB/T 7714
Zhou, XB,Guo, M,Quan, LP,et al. Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2003,9(6):1170-1173.
APA Zhou, XB.,Guo, M.,Quan, LP.,Zhang, W.,Lu, ZM.,...&Xu, NZ.(2003).Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium.WORLD JOURNAL OF GASTROENTEROLOGY,9(6),1170-1173.
MLA Zhou, XB,et al."Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium".WORLD JOURNAL OF GASTROENTEROLOGY 9.6(2003):1170-1173.
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