IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Literature survey on epidemiology and pathology of cardiac fibroma
Torimitsu, Suguru1; Nemoto, Tetsuo1; Wakayama, Megumi1; Okubo, Yoichiro1; Yokose, Tomoyuki2; Kitahara, Kanako3; Ozawa, Tsukasa4; Nakayama, Haruo5; Shinozaki, Minoru1; Sasai, Daisuke1; Ishiwatari, Takao1; Takuma, Kensuke6; Shibuya, Kazutoshi1,7
刊名EUROPEAN JOURNAL OF MEDICAL RESEARCH
2012-03-27
DOI10.1186/2047-783X-17-5
17
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]RIGHT-VENTRICULAR FIBROMA ; RESECTION ; TUMORS
英文摘要

Background: Although cardiac fibroma has been regarded as benign tumor, it presents various symptoms and may lead to death. Unfortunately, only a few studies have reported the epidemiology, embryology, and histopathology of the tumor, and the factors predicting poorer outcome are still obscured.

Methods: In July 2011 we searched for English and Japanese cases of cardiac fibroma using the PubMed and IgakuChuoZasshi databases. We then extracted and sampled raw data from the selected publications in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) style as much as was possible.

Results: Details of a total of 178 patients with cardiac fibroma were retrieved. The mean age was 11.4 years (median: 2.8 years). Tumor sizes ranged from 8.0 to 150.0 mm (mean 53.1 mm). The left ventricle was found to be the most common site associated with the tumor at a rate of 57.3%, followed by the right ventricle, and interventricular septum. The highest mortality was found in patients with septal involvement (58.6%). In all, 111 patients survived among the 160 patients with a recorded outcome. A younger age of the patient at the time of diagnosis was associated with a decreased survival rate. In addition, a significant positive association was found between ages for patients younger than 17 years of age and the diameter of the tumor at the time of diagnosis (r = 0.341, P = 0.006).

Conclusions: Both the younger age of patients at the time of diagnosis and septal involvement can be regarded as factors significantly indicating a poor prognosis. Furthermore, our statistical analyses support the following hypotheses. First, the high ratio of tumor-to-heart size may generate low cardiac output and therefore lead to poor outcome. Second, the ratio of the sites where cardiac fibroma occurred corresponds with the ratio of the muscular weight of the cardiac chamber. Third, cardiac fibroma involving the interventricular septum more frequently induces conduction system disease.

语种英语
WOS记录号WOS:000307333000001
项目编号H22-Shinkou-Ippan-8 ; H23-Shinkou-Ippan-018 ; H20-Nannchi-Ippann-35 ; 23-19 ; 21 ; 28
资助机构Pfizer Inc. ; Janssen Pharmaceutical KK. ; Dainippon Sumitomo Pharma Co. ; Astellas Pharma Inc. ; Taiho Pharmaceutical Co. ; POLA-Pharma Inc. ; Ministry of Health, Labor and Welfare of Japan ; Ministry of Education, Culture, Sports, Science and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66783
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Toho Univ, Sch Med, Dept Surg Pathol, Ota Ku, Tokyo 1438541, Japan
2.Kanagawa Canc Ctr, Dept Pathol, Asahi Ku, Yokohama, Kanagawa 2450815, Japan
3.Toho Univ, Sch Med, Dept Internal Med, Div Rheumatol,Ota Ku, Tokyo 1438541, Japan
4.Toho Univ, Sch Med, Div Cardiovasc Surg, Dept Surg Omori,Ota Ku, Tokyo 1438541, Japan
5.Toho Univ, Ohashi Med Ctr, Dept Neurosurg, Meguro Ku, Tokyo 1538515, Japan
6.Toho Univ, Sch Med, Dept Gastroenterol & Hepatol, Omori Med Ctr,Ota Ku, Tokyo 1438541, Japan
7.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Torimitsu, Suguru,Nemoto, Tetsuo,Wakayama, Megumi,et al. Literature survey on epidemiology and pathology of cardiac fibroma[J]. EUROPEAN JOURNAL OF MEDICAL RESEARCH,2012,17.
APA Torimitsu, Suguru.,Nemoto, Tetsuo.,Wakayama, Megumi.,Okubo, Yoichiro.,Yokose, Tomoyuki.,...&Shibuya, Kazutoshi.(2012).Literature survey on epidemiology and pathology of cardiac fibroma.EUROPEAN JOURNAL OF MEDICAL RESEARCH,17.
MLA Torimitsu, Suguru,et al."Literature survey on epidemiology and pathology of cardiac fibroma".EUROPEAN JOURNAL OF MEDICAL RESEARCH 17(2012).
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