IR@PKUHSC  > 北京大学口腔医学院  > 口腔病理科
学科主题口腔医学
Immunohistochemistry of lymphocytes in benign lymphoadenosis of oral mucosa
Li, S. -X.1; Li, Q.2; Yang, Y. -Q.3; Jin, L. -J.4; Sun, Z.1; Yu, S. -F.5
关键词CD20 CD74 CD3 CD45RO Immunohistochemistry Benign lymphoadenosis of oral mucosa (BLOM)
刊名GENETICS AND MOLECULAR RESEARCH
2015
DOI10.4238/2015.June.29.10
14期:2页:7163-7171
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]FOLLICULAR LYMPHOID HYPERPLASIA ; LICHEN-PLANUS ; HARD PALATE ; NASOPHARYNGEAL CARCINOMA ; T-CELLS ; CHEMOTHERAPY ; RADIOTHERAPY ; PROGRESSION ; SURVIVAL
英文摘要

Benign lymphoadenosis of oral mucosa (BLOM) is a common oral mucosa disease and may be regarded as a precancerous lesion. However, the association between its biological behavior and lymphocyte distribution remains unclear. Therefore, to investigate the characteristics of BLOM, we studied the infiltration of lymphocytes associated with it. The expression levels of CD74, CD20, CD3, and CD45RO were evaluated by immunohistochemical staining in 14 samples from BLOM, 9 samples from BLOM with atypia hyperplasia, 11 samples from BLOM with canceration, and 10 samples from normal oral mucosa tissues. The results were analyzed by two-sample t-test using SPSS 10.0 for Windows, and P < 0.05 was considered to be significant. In normal oral mucosa, positive expression levels of CD3 and CD45RO were presented in the extra-lymphoid follicle, and the expression levels of CD74 and CD20 were negative. In all BLOM groups, the expression level of CD20 was positive except for one case of BLOM with canceration; the expression levels of CD74 were all positive. Positive expression levels of CD3 and CD45RO could be found not only in extra-lymphoid follicles but also in inner-lymphoid follicles in the BLOM groups. The expression levels of CD74 and CD20 in extra-lymphoid follicles, and CD3 and CD45RO in inner-lymphoid follicles in BLOM were significantly higher than in BLOM with canceration. The infiltrated lymphocytes in BLOM comprise T-and B-cells. This indicates that the lymphoid tissue in BLOM is mucosa-associated lymphoid tissue and BLOM is a proliferative lesion.

语种英语
WOS记录号WOS:000357189800157
项目编号30500559 ; 2005B51
资助机构National Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission B
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66792
专题北京大学口腔医学院_口腔病理科
作者单位1.Capital Med Univ, Sch Stomatol, Dept Periodont & Oral Med, Beijing, Peoples R China
2.Capital Med Univ, Sch Stomatol, Dept Prosthodont, Beijing, Peoples R China
3.Univ Hong Kong, Sch Stomatol, Dept Orthodont, Hong Kong, Hong Kong, Peoples R China
4.Univ Hong Kong, Sch Stomatol, Dept Periodont, Hong Kong, Hong Kong, Peoples R China
5.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, S. -X.,Li, Q.,Yang, Y. -Q.,et al. Immunohistochemistry of lymphocytes in benign lymphoadenosis of oral mucosa[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(2):7163-7171.
APA Li, S. -X.,Li, Q.,Yang, Y. -Q.,Jin, L. -J.,Sun, Z.,&Yu, S. -F..(2015).Immunohistochemistry of lymphocytes in benign lymphoadenosis of oral mucosa.GENETICS AND MOLECULAR RESEARCH,14(2),7163-7171.
MLA Li, S. -X.,et al."Immunohistochemistry of lymphocytes in benign lymphoadenosis of oral mucosa".GENETICS AND MOLECULAR RESEARCH 14.2(2015):7163-7171.
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