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学科主题: 口腔医学
题名:
Immunohistochemistry of lymphocytes in benign lymphoadenosis of oral mucosa
作者: Li, S. -X.1; Li, Q.2; Yang, Y. -Q.3; Jin, L. -J.4; Sun, Z.1; Yu, S. -F.5
关键词: CD20 ; CD74 ; CD3 ; CD45RO ; Immunohistochemistry ; Benign lymphoadenosis of oral mucosa (BLOM)
刊名: GENETICS AND MOLECULAR RESEARCH
发表日期: 2015
DOI: 10.4238/2015.June.29.10
卷: 14, 期:2, 页:7163-7171
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]: FOLLICULAR LYMPHOID HYPERPLASIA ; LICHEN-PLANUS ; HARD PALATE ; NASOPHARYNGEAL CARCINOMA ; T-CELLS ; CHEMOTHERAPY ; RADIOTHERAPY ; PROGRESSION ; SURVIVAL
英文摘要:

Benign lymphoadenosis of oral mucosa (BLOM) is a common oral mucosa disease and may be regarded as a precancerous lesion. However, the association between its biological behavior and lymphocyte distribution remains unclear. Therefore, to investigate the characteristics of BLOM, we studied the infiltration of lymphocytes associated with it. The expression levels of CD74, CD20, CD3, and CD45RO were evaluated by immunohistochemical staining in 14 samples from BLOM, 9 samples from BLOM with atypia hyperplasia, 11 samples from BLOM with canceration, and 10 samples from normal oral mucosa tissues. The results were analyzed by two-sample t-test using SPSS 10.0 for Windows, and P < 0.05 was considered to be significant. In normal oral mucosa, positive expression levels of CD3 and CD45RO were presented in the extra-lymphoid follicle, and the expression levels of CD74 and CD20 were negative. In all BLOM groups, the expression level of CD20 was positive except for one case of BLOM with canceration; the expression levels of CD74 were all positive. Positive expression levels of CD3 and CD45RO could be found not only in extra-lymphoid follicles but also in inner-lymphoid follicles in the BLOM groups. The expression levels of CD74 and CD20 in extra-lymphoid follicles, and CD3 and CD45RO in inner-lymphoid follicles in BLOM were significantly higher than in BLOM with canceration. The infiltrated lymphocytes in BLOM comprise T-and B-cells. This indicates that the lymphoid tissue in BLOM is mucosa-associated lymphoid tissue and BLOM is a proliferative lesion.

语种: 英语
所属项目编号: 30500559 ; 2005B51
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission B
WOS记录号: WOS:000357189800157
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66792
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Capital Med Univ, Sch Stomatol, Dept Periodont & Oral Med, Beijing, Peoples R China
2.Capital Med Univ, Sch Stomatol, Dept Prosthodont, Beijing, Peoples R China
3.Univ Hong Kong, Sch Stomatol, Dept Orthodont, Hong Kong, Hong Kong, Peoples R China
4.Univ Hong Kong, Sch Stomatol, Dept Periodont, Hong Kong, Hong Kong, Peoples R China
5.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Li, S. -X.,Li, Q.,Yang, Y. -Q.,et al. Immunohistochemistry of lymphocytes in benign lymphoadenosis of oral mucosa[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(2):7163-7171.
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