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学科主题: 临床医学
题名:
The presence of thyroid peroxidase antibody of IgG2 subclass is a risk factor for thyroid dysfunction in chronic hepatitis C patients
作者: Shao, Cuiping1; Huo, Na1; Zhao, Lanlan2; Gao, Ying2; Fan, Xiaohong1; Zheng, Yingying1; Wang, Lifen1; Lu, Haiying1; Xu, Xiaoyuan1; Guo, Xiaohui2
刊名: EUROPEAN JOURNAL OF ENDOCRINOLOGY
发表日期: 2013-05-01
DOI: 10.1530/EJE-12-0775
卷: 168, 期:5, 页:717-722
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: IMMUNOGLOBULIN-G SUBCLASSES ; INTERFERON-ALPHA THERAPY ; VIRUS-INFECTION ; EXTRAHEPATIC MANIFESTATIONS ; HASHIMOTOS-THYROIDITIS ; HYPOTHYROIDISM ; AUTOANTIBODIES ; DISORDERS ; EPIDEMIOLOGY ; AUTOIMMUNITY
英文摘要:

Objective: To investigate the prevalence of thyroid dysfunction (TD) and IgG subclasses of thyroid autoantibodies (TAs) and to determine the predictive factors of TD in chronic hepatitis C (CHC) patients.

Design: Three hundred and twelve untreated hepatitis C virus-infected patients without a history of TD or treatment with thyroid hormones were enrolled in a cross-sectional study. Clinical and biological factors were statistically analyzed to determine the correlation between TD and this patient population.

Results: The incidence of TD was 12.5% in CHC patients. Clinical hypothyroidism (5.8%) and subclinical hypothyroidism (3.8%) were more frequent than clinical hyperthyroidism (1.6%) and subclinical hyperthyroidism (1.3%). The percentage of TA-positive patients was significantly higher in people >60 years than in those <= 60 years (31.9 vs 18.6%; P=0.042). Positive thyroid peroxidase antibody (TPOAb) was more frequent, and alanine aminotransferase (ALT) levels were lower in patients who displayed TD (TPOAb: 62.1 vs 10.8%, P=0.000; ALT: 43.5 vs 51 IU/l, P=0.046). The positive percentage of TPOAb IgG2 subclass in the TD group was significantly higher than that of patients without TD (66.7 vs 16.7%, P=0.005). Multiple logistic regression analysis indicated that only TPOAb IgG2 subclass positivity was an independent risk factor for TD in CHC patients (odds ratio=8; 95% CI: 1.225-52.246; P=0.030).

Conclusions: TPOAb IgG2 subclass positivity is a risk factor for TD in CHC patients before antiviral treatment. IgG2 subclass of TPOAb might play an important role in the presence of TD in CHC patients. European Journal of Endocrinology 168 717-722

语种: 英语
所属项目编号: 2008ZX10002-013 ; 30771906 ; 20090001110081
项目资助者: National Major Project for Infectious Diseases Control ; National Natural Science Foundation of China ; PhD Programs Foundation of Ministry of Education of China
WOS记录号: WOS:000318003300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66796
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China

Recommended Citation:
Shao, Cuiping,Huo, Na,Zhao, Lanlan,et al. The presence of thyroid peroxidase antibody of IgG2 subclass is a risk factor for thyroid dysfunction in chronic hepatitis C patients[J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY,2013,168(5):717-722.
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