|The presence of thyroid peroxidase antibody of IgG2 subclass is a risk factor for thyroid dysfunction in chronic hepatitis C patients|
|Shao, Cuiping1; Huo, Na1; Zhao, Lanlan2; Gao, Ying2; Fan, Xiaohong1; Zheng, Yingying1; Wang, Lifen1; Lu, Haiying1; Xu, Xiaoyuan1; Guo, Xiaohui2|
|刊名||EUROPEAN JOURNAL OF ENDOCRINOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Endocrinology & Metabolism|
|研究领域[WOS]||Endocrinology & Metabolism|
|关键词[WOS]||IMMUNOGLOBULIN-G SUBCLASSES ; INTERFERON-ALPHA THERAPY ; VIRUS-INFECTION ; EXTRAHEPATIC MANIFESTATIONS ; HASHIMOTOS-THYROIDITIS ; HYPOTHYROIDISM ; AUTOANTIBODIES ; DISORDERS ; EPIDEMIOLOGY ; AUTOIMMUNITY|
Objective: To investigate the prevalence of thyroid dysfunction (TD) and IgG subclasses of thyroid autoantibodies (TAs) and to determine the predictive factors of TD in chronic hepatitis C (CHC) patients.
Design: Three hundred and twelve untreated hepatitis C virus-infected patients without a history of TD or treatment with thyroid hormones were enrolled in a cross-sectional study. Clinical and biological factors were statistically analyzed to determine the correlation between TD and this patient population.
Results: The incidence of TD was 12.5% in CHC patients. Clinical hypothyroidism (5.8%) and subclinical hypothyroidism (3.8%) were more frequent than clinical hyperthyroidism (1.6%) and subclinical hyperthyroidism (1.3%). The percentage of TA-positive patients was significantly higher in people >60 years than in those <= 60 years (31.9 vs 18.6%; P=0.042). Positive thyroid peroxidase antibody (TPOAb) was more frequent, and alanine aminotransferase (ALT) levels were lower in patients who displayed TD (TPOAb: 62.1 vs 10.8%, P=0.000; ALT: 43.5 vs 51 IU/l, P=0.046). The positive percentage of TPOAb IgG2 subclass in the TD group was significantly higher than that of patients without TD (66.7 vs 16.7%, P=0.005). Multiple logistic regression analysis indicated that only TPOAb IgG2 subclass positivity was an independent risk factor for TD in CHC patients (odds ratio=8; 95% CI: 1.225-52.246; P=0.030).
Conclusions: TPOAb IgG2 subclass positivity is a risk factor for TD in CHC patients before antiviral treatment. IgG2 subclass of TPOAb might play an important role in the presence of TD in CHC patients. European Journal of Endocrinology 168 717-722
|作者单位||1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China|
2.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China
|Shao, Cuiping,Huo, Na,Zhao, Lanlan,et al. The presence of thyroid peroxidase antibody of IgG2 subclass is a risk factor for thyroid dysfunction in chronic hepatitis C patients[J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY,2013,168(5):717-722.|
|APA||Shao, Cuiping.,Huo, Na.,Zhao, Lanlan.,Gao, Ying.,Fan, Xiaohong.,...&Guo, Xiaohui.(2013).The presence of thyroid peroxidase antibody of IgG2 subclass is a risk factor for thyroid dysfunction in chronic hepatitis C patients.EUROPEAN JOURNAL OF ENDOCRINOLOGY,168(5),717-722.|
|MLA||Shao, Cuiping,et al."The presence of thyroid peroxidase antibody of IgG2 subclass is a risk factor for thyroid dysfunction in chronic hepatitis C patients".EUROPEAN JOURNAL OF ENDOCRINOLOGY 168.5(2013):717-722.|