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学科主题: 临床医学
题名:
FINDING OF MICRODAMAGE MORPHOLOGY DIFFERENCES IN MOUSE FEMORAL BONES WITH DISTINCT MINERALIZATION LEVELS
作者: Dong, X. Neil1; Leng, Huijie2; Ran, Qitao3; Wang, Xiaodu1
关键词: Linear microcrack ; diffuse damage ; mineralization ; nanoindentation ; fatigue
刊名: JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
发表日期: 2011-04-01
DOI: 10.1142/S0219519410003757
卷: 11, 期:2, 页:423-432
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Engineering, Biomedical
研究领域[WOS]: Biophysics ; Engineering
关键词[WOS]: IN-VIVO ; CORTICAL BONE ; COMPACT-BONE ; AGE ; MICE ; MICROSTRUCTURE ; ACCUMULATION ; STRENGTH ; DENSITY
英文摘要:

Microdamage progression in bone is dependent on the ultrastructure of the tissue. Thus, any pathological changes in bone ultrastructure may be reflected in the pattern and capacity of microdamage accumulation. A previous numerical study of microdamage progression in bone using a probabilistic failure analysis approach predicts that the microdamage morphology (either linear microcracks or diffuse damage) is very sensitive to the level of mineralization in bone, which is also implicated in some experimental observations. To examine the prediction, femurs from two strains of mice (C57BL/6J, N = 10 and C3H/HeJ, N = 11) that have distinct mineralization levels were fatigued under four-point bending to create damage in the bone tissues. After testing, the microdamage morphology of the bone samples was examined using bulk-staining technique with basic fuchsin. The results demonstrate that more linear microcracks are observed in femurs of C3H/HeJ (higher mineralization), whereas more diffuse-like damage is found in C57BL/6J femurs (less mineralized). Compared with linear microcracks, the formation of diffuse damage tends to dissipate more energy and help bone to avoid catastrophic failures. Therefore, results from this study may help explain why highly mineralized bone tends to be more brittle. Observations from this study are consistent with the numerical prediction from the previous study, suggesting that mineralization has a significant effect on the microdamage morphology of bone.

语种: 英语
所属项目编号: AG027780
项目资助者: NIH/NIA
WOS记录号: WOS:000292694800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66801
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Univ Texas San Antonio, Dept Mech Engn, San Antonio, TX 78249 USA
2.Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100191, Peoples R China
3.Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, Barshop Inst Longev & Aging Studies, San Antonio, TX 78245 USA

Recommended Citation:
Dong, X. Neil,Leng, Huijie,Ran, Qitao,et al. FINDING OF MICRODAMAGE MORPHOLOGY DIFFERENCES IN MOUSE FEMORAL BONES WITH DISTINCT MINERALIZATION LEVELS[J]. JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY,2011,11(2):423-432.
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