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学科主题临床医学
FINDING OF MICRODAMAGE MORPHOLOGY DIFFERENCES IN MOUSE FEMORAL BONES WITH DISTINCT MINERALIZATION LEVELS
Dong, X. Neil1; Leng, Huijie2; Ran, Qitao3; Wang, Xiaodu1
关键词Linear microcrack diffuse damage mineralization nanoindentation fatigue
刊名JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
2011-04-01
DOI10.1142/S0219519410003757
11期:2页:423-432
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Engineering, Biomedical
研究领域[WOS]Biophysics ; Engineering
关键词[WOS]IN-VIVO ; CORTICAL BONE ; COMPACT-BONE ; AGE ; MICE ; MICROSTRUCTURE ; ACCUMULATION ; STRENGTH ; DENSITY
英文摘要

Microdamage progression in bone is dependent on the ultrastructure of the tissue. Thus, any pathological changes in bone ultrastructure may be reflected in the pattern and capacity of microdamage accumulation. A previous numerical study of microdamage progression in bone using a probabilistic failure analysis approach predicts that the microdamage morphology (either linear microcracks or diffuse damage) is very sensitive to the level of mineralization in bone, which is also implicated in some experimental observations. To examine the prediction, femurs from two strains of mice (C57BL/6J, N = 10 and C3H/HeJ, N = 11) that have distinct mineralization levels were fatigued under four-point bending to create damage in the bone tissues. After testing, the microdamage morphology of the bone samples was examined using bulk-staining technique with basic fuchsin. The results demonstrate that more linear microcracks are observed in femurs of C3H/HeJ (higher mineralization), whereas more diffuse-like damage is found in C57BL/6J femurs (less mineralized). Compared with linear microcracks, the formation of diffuse damage tends to dissipate more energy and help bone to avoid catastrophic failures. Therefore, results from this study may help explain why highly mineralized bone tends to be more brittle. Observations from this study are consistent with the numerical prediction from the previous study, suggesting that mineralization has a significant effect on the microdamage morphology of bone.

语种英语
WOS记录号WOS:000292694800010
项目编号AG027780
资助机构NIH/NIA
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66801
专题北京大学第三临床医学院_骨科
作者单位1.Univ Texas San Antonio, Dept Mech Engn, San Antonio, TX 78249 USA
2.Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100191, Peoples R China
3.Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, Barshop Inst Longev & Aging Studies, San Antonio, TX 78245 USA
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Dong, X. Neil,Leng, Huijie,Ran, Qitao,et al. FINDING OF MICRODAMAGE MORPHOLOGY DIFFERENCES IN MOUSE FEMORAL BONES WITH DISTINCT MINERALIZATION LEVELS[J]. JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY,2011,11(2):423-432.
APA Dong, X. Neil,Leng, Huijie,Ran, Qitao,&Wang, Xiaodu.(2011).FINDING OF MICRODAMAGE MORPHOLOGY DIFFERENCES IN MOUSE FEMORAL BONES WITH DISTINCT MINERALIZATION LEVELS.JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY,11(2),423-432.
MLA Dong, X. Neil,et al."FINDING OF MICRODAMAGE MORPHOLOGY DIFFERENCES IN MOUSE FEMORAL BONES WITH DISTINCT MINERALIZATION LEVELS".JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY 11.2(2011):423-432.
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