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学科主题: 精神卫生
题名:
Association study of the human FZD3 locus with schizophrenia
作者: Yang, JZ; Si, TM; Ling, YS; Ruan, Y; Han, YH; Wang, XL; Zhang, HY; Kong, QM; Li, XN; Liu, C; Zhang, DR; Zhou, M; Yu, YQ; Liu, SZ; Shu, L; Ma, DL; Wei, J; Zhang, D
关键词: association study ; chromosome 8p ; FZD3 gene ; schizophrenia ; single nucleotide polymorphisms ; Wnt family
刊名: BIOLOGICAL PSYCHIATRY
发表日期: 2003-12-01
DOI: 10.1016/S0006-3223(03)00291-9
卷: 54, 期:11, 页:1298-1301
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: ABNORMALITIES ; SPECIFICATION ; FRIZZLED-3 ; EXPRESSION ; LINKAGE ; REGION ; BRAIN ; WNT-1 ; 8P
英文摘要:

Background: The FZD3 protein is a transmembrane receptor for secreted Wnt glycoproteins involved in the Wnt signal transduction cascades. The alteration of Wnt signal transduction cascades has been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Because the human FZD3 gene is mapped to chromosome 8p21, which is a potential region containing a gene for schizophrenia, it may play a role in conferring susceptibility to the disease.

Methods: This study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the FZD3 locus by using the polymerase chain reaction-based restriction fragment length polymorphism (RFLP) analysis among 246 schizophrenic family trios of Chinese Han descent.

Results: The transmission disequilibrium test (TDT) demonstrated that the three SNPs all showed a preferential transmission with a p value ranging from .0003-.000007. The global chi-squared test for haplotype transmission also showed a strong association (chi(2) = 48.84, df = 7, p < .000001).

Conclusions: The strong association between the FZD3 locus and schizophrenia suggests that the gene itself may play a role in underlying schizophrenia, although a nearby gene responsible for predisposing to the illness cannot be ruled out.

语种: 英语
WOS记录号: WOS:000186792300020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66806
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Jilin Univ, Ctr Genom Med, Changchun 130023, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China

Recommended Citation:
Yang, JZ,Si, TM,Ling, YS,et al. Association study of the human FZD3 locus with schizophrenia[J]. BIOLOGICAL PSYCHIATRY,2003,54(11):1298-1301.
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