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Association study of the human FZD3 locus with schizophrenia
Yang, JZ; Si, TM; Ling, YS; Ruan, Y; Han, YH; Wang, XL; Zhang, HY; Kong, QM; Li, XN; Liu, C; Zhang, DR; Zhou, M; Yu, YQ; Liu, SZ; Shu, L; Ma, DL; Wei, J; Zhang, D
关键词association study chromosome 8p FZD3 gene schizophrenia single nucleotide polymorphisms Wnt family
刊名BIOLOGICAL PSYCHIATRY
2003-12-01
DOI10.1016/S0006-3223(03)00291-9
54期:11页:1298-1301
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Psychiatry
关键词[WOS]ABNORMALITIES ; SPECIFICATION ; FRIZZLED-3 ; EXPRESSION ; LINKAGE ; REGION ; BRAIN ; WNT-1 ; 8P
英文摘要

Background: The FZD3 protein is a transmembrane receptor for secreted Wnt glycoproteins involved in the Wnt signal transduction cascades. The alteration of Wnt signal transduction cascades has been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Because the human FZD3 gene is mapped to chromosome 8p21, which is a potential region containing a gene for schizophrenia, it may play a role in conferring susceptibility to the disease.

Methods: This study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the FZD3 locus by using the polymerase chain reaction-based restriction fragment length polymorphism (RFLP) analysis among 246 schizophrenic family trios of Chinese Han descent.

Results: The transmission disequilibrium test (TDT) demonstrated that the three SNPs all showed a preferential transmission with a p value ranging from .0003-.000007. The global chi-squared test for haplotype transmission also showed a strong association (chi(2) = 48.84, df = 7, p < .000001).

Conclusions: The strong association between the FZD3 locus and schizophrenia suggests that the gene itself may play a role in underlying schizophrenia, although a nearby gene responsible for predisposing to the illness cannot be ruled out.

语种英语
WOS记录号WOS:000186792300020
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被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66806
专题北京大学精神卫生研究所
作者单位1.Jilin Univ, Ctr Genom Med, Changchun 130023, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
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GB/T 7714
Yang, JZ,Si, TM,Ling, YS,et al. Association study of the human FZD3 locus with schizophrenia[J]. BIOLOGICAL PSYCHIATRY,2003,54(11):1298-1301.
APA Yang, JZ.,Si, TM.,Ling, YS.,Ruan, Y.,Han, YH.,...&Zhang, D.(2003).Association study of the human FZD3 locus with schizophrenia.BIOLOGICAL PSYCHIATRY,54(11),1298-1301.
MLA Yang, JZ,et al."Association study of the human FZD3 locus with schizophrenia".BIOLOGICAL PSYCHIATRY 54.11(2003):1298-1301.
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