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学科主题: 药物依赖
题名:
An-jun-ning, a traditional herbal formula, attenuates spontaneous withdrawal symptoms via modulation of the dopamine system in morphine-dependent rats
作者: Gao, Jin-Long1; Tu, Shao-Ang1; Liu, Jia1; Zhang, Jin-Ming2; Huang, Yiyun3; Han, Mei1; Liang, Jian-Hui4
关键词: Morphine dependence ; Dopamine transporter ; Dopamine D(2)receptor ; Tyrosine hydroxylase ; An-jun-ning
刊名: BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2014-08-19
DOI: 10.1186/1472-6882-14-308
卷: 14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; DRUG-ADDICTION ; LEVO-TETRAHYDROPALMATINE ; HEROIN USERS ; AVAILABILITY ; TRANSPORTER ; ABSTINENCE ; REINSTATEMENT ; MEDICINE ; BRAIN
英文摘要:

Background: The dopamine system, which is involved in drug dependence, can be damaged by opioid abuse. However, current clinical medicines cannot reverse these damages in the brain, which are believed to be a key reason for the high relapse rate after abstinence treatment. This study aimed to investigate the effects of An-jun-ning (AJN), a commercial traditional Chinese medicine formula used for the treatment of opioid addiction, on the dopamine system in morphine-dependent rats and to explore the possible mechanism underlying its therapeutic effects.

Methods: The morphine dependence model was obtained through injections of morphine at increasing doses for 8 days. The AJN pre-treatment group was administered AJN 30 min before each morphine administration, and the AJN post-treatment groups were treated with AJN for 10 days after withdrawal. Spontaneous withdrawal symptoms (wet dog shakes, and episodes of writhing) were observed after withdrawal. Autoradiography study and/or immunohistochemical staining were used to examine the levels of dopamine transporter (DAT), dopamine D-2 receptor (D2R) and tyrosine hydroxylase (TH).

Results: (1) Pre-treatment with AJN attenuates wet dog shakes and episodes of writhing to approximately 50% or less of those observed in the morphine group (p < 0.01). (2) AJN post-treatment dose-dependently reduced the number of wet dog shakes (p < 0.01), and the episodes of writhing (p < 0.01). (3) Pre-treatment with AJN effectively interdicted the morphine-induced decreases in the levels of DAT, D2R, and TH in the striatum (p < 0.01) such that they remained at nearly normal levels. (4) Post-treatment with AJN restored DAT and D2R to the normal levels (p < 0.01) and the level of TH to 87% of normal in the striatum.

Conclusions: AJN can effectively alleviate opioid withdrawal symptoms and preserve or restore the DAT, D2R, and TH levels in the striatum. The mechanism underlying the effect of AJN on withdrawal symptoms may be related to the modulation of the dopamine system by AJN. These results suggest that AJN may help to prevent relapse in opioid dependence treatment.

语种: 英语
所属项目编号: 2008BAI49B04 ; 81173139 ; 21233003
项目资助者: National Key Technology R D Program ; China National Science Foundation ; Major Research Plan of NSFC
WOS记录号: WOS:000341320000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66809
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Beijing Normal Univ, Dept Chem, Key Lab Radiopharmaceut, Minist Educ, Beijing 100875, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China
3.Yale Univ, Sch Med, Dept Diagnost Radiol, Yale PET Ctr, New Haven, CT 06510 USA
4.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100191, Peoples R China

Recommended Citation:
Gao, Jin-Long,Tu, Shao-Ang,Liu, Jia,et al. An-jun-ning, a traditional herbal formula, attenuates spontaneous withdrawal symptoms via modulation of the dopamine system in morphine-dependent rats[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,14.
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