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学科主题: 临床医学
题名:
Propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis
作者: Zhao, MH; Chen, M; Gao, Y; Wang, HY
刊名: KIDNEY INTERNATIONAL
发表日期: 2006-04-01
DOI: 10.1038/sj.ki.5000387
卷: 69, 期:8, 页:1477-1481
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ANTIENDOTHELIAL CELL ANTIBODIES ; GRAVES-DISEASE ; ANTIMYELOPEROXIDASE ANTIBODIES ; POSITIVE VASCULITIS ; ANTITHYROID DRUGS ; ANCA ; INACTIVATION ; NEUTROPHILS ; SERA
英文摘要:

A 20-year-old woman was referred to Peking University First Hospital, Beijing, China, owing to massive pulmonary hemorrhage and gross hematuria. She had been well until 2 years before admission when she was diagnosed with Graves′ disease and was treated with propylthiouracil (PTU) 300 mg/day first and then maintained with PTU 100 mg/day. Five months before admission, she complained of palpitations and was found to have an elevated serum T3 and T4 and decreased thyroid stimulating hormones. In response, the dose of PTU was changed to 300 mg/day by her local doctors. Shortly thereafter, she started to complain of arthralgia, myalgia, and skin rash. Three months before admission, she developed a cough, hemoptysis, and gross hematuria, and subsequently a gradual decline in her hearing, ′red eye′, and weight loss. One week before admission, her PTU dose was further increased to 450 mg/day and then the patient became severely ill with massive pulmonary hemorrhage.

At physical examination on admission, her paleness, exophthalmos, and goiter were revealed. The blood pressure was 120/80 mm Hg, the pulse 96 beats/min, the respiratory rate 24 breaths/min, and the temperature 37.2 degrees C. The body weight was 45 kg. Auscultation of the lungs revealed scattered expiratory wheezes and coarse bronchial breath sounds. A cardiac examination revealed tachycardia with normal heart sounds and no murmurs, rubs, or gallops. The abdomen was soft, nontender. There was no edema on lower extremities.

Laboratory data are shown in Tables 1 and 2. Chest radiography indicated massive pulmonary hemorrhage ( Figure 1a). Her serum perinuclear cytoplasmic stained pattern on ethanol-fixed neutrophil was positive with specificity to myeloperoxidase, lactoferrin, and azurocidin. Anti-nuclear antibody and anti-glomerular basement membrane antibody were negative.

语种: 英语
WOS记录号: WOS:000237008600033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66812
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Zhao, MH,Chen, M,Gao, Y,et al. Propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis[J]. KIDNEY INTERNATIONAL,2006,69(8):1477-1481.
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