IR@PKUHSC  > 北京大学第二临床医学院  > 皮科
学科主题临床医学
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21
Zhang, Xue-Jun1,2,3,4; Huang, Wei5,6; Yang, Sen1,2,3,4; Sun, Liang-Dan1,2,3,4; Zhang, Feng-Yu1,2,3,4,7; Zhu, Qi-Xing1,2,3,4; Zhang, Fu-Ren4; Zhang, Chi1,2,3,4; Du, Wen-Hui1,2,3,4; Pu, Xiong-Ming3,4,8; Li, Hui1,2,3,4; Xiao, Feng-Li1,2,3,4; Wang, Zai-Xing1,2,3,4; Cui, Yong1,2,3,4; Hao, Fei9; Zheng, Jie10; Yang, Xue-Qin4,11; Cheng, Hui1,2,3,4; He, Chun-Di12; Liu, Xiao-Ming1,13; Xu, Li-Min14; Zheng, Hou-Feng1,2,3,4; Zhang, Shu-Mei1,2,3,4; Zhang, Jian-Zhong15; Wang, Hong-Yan1,2,3,4; Cheng, Yi-Lin1,2,3,4; Ji, Bi-Hua1,16; Fang, Qiao-Yun1,3; Li, Yu-Zhen1,17; Zhou, Fu-Sheng1,3; Han, Jian-Wen1,2,3,4; Quan, Cheng1,2,3,4; Chen, Bin1,2,3,4; Liu, Jun-Lin1,2,3,4; Li, Da1,2,3,4; Fan, Li1,2,3,4; Zhang, An-Ping1,2,3,4; Liu, Sheng-Xiu1,2,3,4; Yang, Chun-Jun1,2,3,4; Wang, Pei-Guang1,2,3,4; Zhou, Wen-Ming1,2,3,4; Lin, Guo-Shu1,2,3,4; Wu, Wei-Dong4,8; Fan, Xing1,2,3,4; Gao, Min1,2,3,4; Yang, Bao-Qi4,7; Lu, Wen-Sheng1,2,3,4; Zhang, Zheng1,2,3,4; Zhu, Kun-Ju1,2,3,4; Shen, Song-Ke1,2,3,4; Li, Min1,2,3,4; Zhang, Xiao-Yan1,2,3,4; Cao, Ting-Ting1,2,3,4; Ren, Wei1,2,3,4; Zhang, Xin1,2,3,4; He, Jun1,2,3,4; Tang, Xian-Fa1,2,3,4; Lu, Shun1,2,3,4; Yang, Jian-Qiang1,2,3,4; Zhang, Lin1,2,3,4; Wang, Dan-Ni1,2,3,4; Yuan, Feng1,2,3,4; Yin, Xian-Yong1,2,3,4; Huang, Hong-Jie5,6; Wang, Hai-Feng5,6; Lin, Xin-Yi18; Liu, Jian-Jun1,2,3,18
刊名NATURE GENETICS
2009-02-01
DOI10.1038/ng.310
41期:2页:205-210
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
资助者Anhui Provincial Special Scientific ; High-Tech Research and Development Program of China ; Key Project of Natural Science Foundation of China ; National Basic Research Program of China ; General Program of National Natural Science Foundation of China ; Agency for Science &amp ; Technology and Research of Singapore (A*STAR) ; Anhui Provincial Special Scientific ; High-Tech Research and Development Program of China ; Key Project of Natural Science Foundation of China ; National Basic Research Program of China ; General Program of National Natural Science Foundation of China ; Agency for Science &amp ; Technology and Research of Singapore (A*STAR)
研究领域[WOS]Genetics & Heredity
关键词[WOS]VULGARIS ; IL12B ; POLYMORPHISMS ; POPULATION ; PROTEINS ; SEQUENCE ; COMPLEX ; IL23R ; SKIN
英文摘要

We report the first large genome-wide association study (GWAS) in a Chinese population to identify susceptibility variants for psoriasis using a two-stage case-control design. In the first stage, we carried out a genome-wide association analysis in 1,139 cases and 1,132 controls of Chinese Han ancestry using Illumina Human 610-Quad BeadChips. In the second stage, we took top SNPs forward for replication in two independent samples of 5,182 cases and 6,516 controls of Chinese Han ancestry, and 539 cases and 824 controls of Chinese Uygur ancestry. In addition to the strong replication for two known susceptibility loci MHC (rs1265181, P 1.93 x 10(-208), OR = 22.62) and IL12B (rs3213094, P(combined) = 2.58 x 10(-26), OR = 0.78), we identified a new susceptibility locus within the LCE gene cluster on 1q21 (rs4085613, P(combined) = 6.69 x 10(-30), OR = 0.76).

语种英语
所属项目编号2007-7 ; 2007AA02Z161 ; 30530670 ; 2007B516801 ; 30671895 ; 30771196 ; 30771942
资助者Anhui Provincial Special Scientific ; High-Tech Research and Development Program of China ; Key Project of Natural Science Foundation of China ; National Basic Research Program of China ; General Program of National Natural Science Foundation of China ; Agency for Science &amp ; Technology and Research of Singapore (A*STAR) ; Anhui Provincial Special Scientific ; High-Tech Research and Development Program of China ; Key Project of Natural Science Foundation of China ; National Basic Research Program of China ; General Program of National Natural Science Foundation of China ; Agency for Science &amp ; Technology and Research of Singapore (A*STAR)
WOS记录号WOS:000263091300021
引用统计
被引频次:256[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66814
专题北京大学第二临床医学院_皮科
作者单位1.Chinese Natl Human Genome Ctr, Shanghai 201203, Peoples R China
2.Gen Hosp AF, Dept Dermatol, PLA, Beijing 100036, Peoples R China
3.Genome Inst Singapore, Singapore 138672, Singapore
4.Anhui Med Univ, Inst Dermatol, Hosp 1, Hefei 230022, Anhui, Peoples R China
5.Anhui Med Univ, Dept Dermatol, Hosp 1, Hefei 230022, Anhui, Peoples R China
6.Minist Educ & Anhui Prov, Key Lab Gene Resource Utilizat Severe Dis, Hefei 230032, Anhui, Peoples R China
7.Anhui Med Univ, Dept Dermatol & Venerol, Hefei 230032, Anhui, Peoples R China
8.Natl Engn Ctr Biochip Design & Engineer, Shanghai 201203, Peoples R China
9.Shandong Prov Inst Dermatol & Venereol, Jinan 250022, Shandong, Peoples R China
10.Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Dermatol, Urumqi 830001, Xinjiang, Peoples R China
11.Third Mil Med Univ, Dept Dermatol, Southwest Hosp, Chongqing 400038, Peoples R China
12.Shanghai Jiao Tong Univ, Sch Med, Dept Dermatol, Ruijin Hosp, Shanghai 200025, Peoples R China
13.China Med Univ, Dept Dermatol, Hosp 1, Shenyang 110001, Liaoning, Peoples R China
14.Dalian Med Univ, Dept Dermatol, Affiliated Hosp 1, Dalian 116011, Liaoning, Peoples R China
15.Changzheng Hosp, Dept Dermatol, Tianjin 300120, Peoples R China
16.Peking Univ, Dept Dermatol, Peoples Hosp, Beijing 100044, Peoples R China
17.Wannan Med Coll, Dept Dermatol, Yijishan Hosp, Wuhu 241000, Anhui, Peoples R China
18.Harbin Med Coll, Dept Dermatol, Affiliated Hosp 2, Harbin 150086, Heilongjiang, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xue-Jun,Huang, Wei,Yang, Sen,et al. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21[J]. NATURE GENETICS,2009,41(2):205-210.
APA Zhang, Xue-Jun.,Huang, Wei.,Yang, Sen.,Sun, Liang-Dan.,Zhang, Feng-Yu.,...&Liu, Jian-Jun.(2009).Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21.NATURE GENETICS,41(2),205-210.
MLA Zhang, Xue-Jun,et al."Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21".NATURE GENETICS 41.2(2009):205-210.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Xue-Jun]的文章
[Huang, Wei]的文章
[Yang, Sen]的文章
百度学术
百度学术中相似的文章
[Zhang, Xue-Jun]的文章
[Huang, Wei]的文章
[Yang, Sen]的文章
必应学术
必应学术中相似的文章
[Zhang, Xue-Jun]的文章
[Huang, Wei]的文章
[Yang, Sen]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。