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学科主题: 临床医学
题名:
Protective effect of rhGLP-1 (7-36) on brain ischemia/reperfusion damage in diabetic rats
作者: Zhao, Libo1; Xu, Jia2; Wang, Qian1; Qian, Zhonglian3; Feng, Wanyu1; Yin, Xiaoxing4; Fang, Yi1
关键词: GLP-1 ; Brain ischemia/reperfusion ; Diabetic rats ; Oxidative stress
刊名: BRAIN RESEARCH
发表日期: 2015-03-30
DOI: 10.1016/j.brainres.2015.01.014
卷: 1602, 页:153-159
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: ACUTE ISCHEMIC-STROKE ; PEPTIDE-1 RECEPTOR ; CEREBRAL-ISCHEMIA ; GLUCAGON ; GLUCOSE ; MODEL ; NEUROPROTECTION ; EXENDIN-4 ; AGONIST ; DISEASE
英文摘要:

In recent years, GLP-1 and its analogs have been developed for the treatment of type 2 diabetes. It has been reported that stimulating the GLP-1 receptor can protect neurons against metabolic and oxidative insults, and therefore can be used in the treatment of stroke and Parkinson′s disease. The present study aimed to examine the neuroprotective effects of rhGLP-1 (7-36) and its possible mechanisms against acute ischemia/reperfusion injuries induced by middle cerebral artery occlusion (MCAO) in diabetic rats. The type 2 diabetic rat model was established by a combination of a high-fat diet and low-dose streptozotocin (STZ). RhGLP-1 (7-36) (20, 40, 80 mu g/kg) was given intraperitoneally before reperfusion. The neuroprotective effects of rhGLP-1 (7-36) were evaluated by changes in neurological deficit scores and 2,3,5-Triphenyltetrazolium chloride (TTC) staining. Changes in blood glucose were used to assess hypoglycemic effects. The content of malondialdehyde (MDA) and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), inducible nitric oxide syntheses (iNOS) and endothelial nitric oxide syntheses (eNOS) after MCAO/R administration (2 h and 46 h) were examined to investigate the possible mechanisms of RhGLP-1 (7-36). Haematoxylin and eosin (H&E) staining was used for histopathological observation. Compared with the control group, rhGLP-1 (7-36)-treated groups decreased nerve function deficiency scores; significantly reduced infarction volume percentage, MDA, iNOS and blood glucose; and significantly increased SOD, GSH-PX and eNOS. In addition, rhGLP-1 (7-36) groups enhanced the density of surviving neurons and increased vascular proliferation. The current study suggests a neuroprotective effect of rhGLP-1 (7-36) in diabetic MCAO/R rats since anti-oxidative and anti-nitrosative stress effects can contribute to beneficial effects against ischemia/reperfusion injury. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: RDB2013-22
项目资助者: Peking University People&prime ; s Hospital Research and Development Funds
WOS记录号: WOS:000353082300017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66817
Appears in Collections:北京大学第二临床医学院_药剂科_期刊论文

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作者单位: 1.First Hosp, Dept Pharm, Hohhot 010010, Peoples R China
2.Mawangdui Hosp, Dept Pharm, Changsha 410016, Hunan, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Pharm, Beijing 100044, Peoples R China
4.Xuzhou Med Coll, Dept Pharm, Xuzhou 221004, Peoples R China

Recommended Citation:
Zhao, Libo,Xu, Jia,Wang, Qian,et al. Protective effect of rhGLP-1 (7-36) on brain ischemia/reperfusion damage in diabetic rats[J]. BRAIN RESEARCH,2015,1602:153-159.
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