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In vitro inhibition of oral Candida albicans by chicken egg yolk antibody (IgY)
Wang, X. Z.2; Fan, B.2,3; Liu, L. G.4; Hu, X. Y.1; Li, R. Y.5; Wei, Y.1; Wan, Z.5; Deng, X. L.1
关键词antibodies Candida albicans chickens egg yolk minimal inhibitory concentration stomatitis denture
刊名MYCOPATHOLOGIA
2008-06-01
DOI10.1007/s11046-008-9097-0
165期:6页:381-387
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
研究领域[WOS]Mycology
关键词[WOS]ESCHERICHIA-COLI ; PASSIVE-IMMUNIZATION ; MONOCLONAL-ANTIBODY ; DENTURE STOMATITIS ; IMMUNOGLOBULINS ; PROTECTION ; PROTEIN ; RABBIT
英文摘要

This study was conducted to measure Candida albicans-specific chicken egg yolk antibody (IgY) inhibition of fluconazole-sensitive and resistant strains of C. albicans in order to assess potential use in the prevention and treatment of oral candidiasis. In this study, laying hens were immunized, and IgY was extracted by water dilution. The Minimal Inhibitory Concentrations (MICs) of IgY for inhibiting C. albicans growth were determined using the broth microdilution method from the CLSI M27-A2 protocol. Fluconazole (FLC) was used as the control. The results were analyzed with the chi(2) test. The anti-Candida titer of anti-C. albicans IgY was 1:12,000. The concentration of the IgY extract that effectively inhibited the growth of C. albicans was between 1.25 g/l and 5.0 g/l, and the efficacy rate was 82.98% during the observed 24-48 h time period. No correlation was recorded between the drug resistance of FLC and growth inhibition by IgY. It was concluded that anti-C. albicans IgY inhibited the growth of C. albicans in vitro and there was no correlation between the drug resistance of FLC and the growth inhibition by IgY (P > 0.99).

语种英语
WOS记录号WOS:000256091200004
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66820
专题北京大学口腔医学院_口腔修复科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Special Dent, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
3.Capital Med Univ, Sch Stomatol, Special Dent Clin, Beijing 100050, Peoples R China
4.Jilin Univ, Coll Anim Sci & Vet Med, Changchun 130062, Peoples R China
5.Peking Univ, Res Ctr Med Mycol, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Wang, X. Z.,Fan, B.,Liu, L. G.,et al. In vitro inhibition of oral Candida albicans by chicken egg yolk antibody (IgY)[J]. MYCOPATHOLOGIA,2008,165(6):381-387.
APA Wang, X. Z..,Fan, B..,Liu, L. G..,Hu, X. Y..,Li, R. Y..,...&Deng, X. L..(2008).In vitro inhibition of oral Candida albicans by chicken egg yolk antibody (IgY).MYCOPATHOLOGIA,165(6),381-387.
MLA Wang, X. Z.,et al."In vitro inhibition of oral Candida albicans by chicken egg yolk antibody (IgY)".MYCOPATHOLOGIA 165.6(2008):381-387.
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