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学科主题临床医学
The metabolic effects of once daily extended-release metformin in patients with type 2 diabetes: a multicentre study
Gao, H.1; Xiao, W.1; Wang, C.1; Zhang, J.2; Yang, Y.3; Yang, J.3; Yang, W.2; Hong, T.1
刊名INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
2008-05-01
DOI10.1111/j.1742-1241.2008.01733.x
62期:5页:695-700
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal ; Pharmacology & Pharmacy
研究领域[WOS]General & Internal Medicine ; Pharmacology & Pharmacy
关键词[WOS]INSULIN SENSITIVITY ; GLYCEMIC CONTROL ; DOUBLE-BLIND ; GLUCOSE ; EFFICACY ; MELLITUS ; PHARMACOKINETICS ; HYPERGLYCEMIA ; TOLERABILITY ; FORMULATION
英文摘要

Aim: To investigate the effects of extended-release metformin (MXR) compared with immediate-release metformin (MIR) on post-prandial glycaemic excursion, chronic glycaemia, lipid profiles, insulin resistance and islet function in type 2 diabetes. Methods: A randomised, open-labelled, positive-controlled multicentre study was conducted on 150 Chinese patients with type 2 diabetes. After 2 weeks of run-in period with MIR, 150 subjects were randomised into MXR group and MIR group. The patients in MXR group were assigned to take MXR 1500 mg once daily after dinner, while the patients in MIR group were assigned to continue MIR 500 mg thrice daily after meals for 12 weeks. Standard meal tests were carried out at baseline and at the end of this study. Plasma glucose, serum insulin, HbA1c and lipid profiles were measured. Homeostasis model assessment (HOMA) was used to evaluate insulin resistance index (HOMA-IR) and islet beta-cell function index (HOMA-B). Results: Either MIR or MXR modestly, but significantly decreased HbA1c levels and body mass index (BMI) after 12 weeks of treatment. However, there were no significant differences between two groups. The post-prandial glycaemia at 120 min after a standard meal in MXR group was higher than in MIR group (11.02 +/- 3.08 mmol/l vs. 9.74 +/- 2.61 mmol/l, p < 0.05). Moreover, no differences in the areas under curve of insulin release response, HOMA-B, HOMA-IR and lipid profiles were found within or between groups after 12 weeks of treatment. Conclusion: The effects of once daily MXR on chronic glycaemia, BMI, lipid profiles, insulin resistance and islet function are comparable with that of thrice daily MIR in oriental population.

语种英语
WOS记录号WOS:000254950300010
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66821
专题北京大学第三临床医学院_内分泌科
作者单位1.Peking Univ, Hosp 3, Dept Endocrinol, Beijing 100038, Peoples R China
2.China Japan Friendship Hosp, Dept Endocrinol, Beijing, Peoples R China
3.Capital Med Univ, Beijing Tong Ren Hosp, Dept Endocrinol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Gao, H.,Xiao, W.,Wang, C.,et al. The metabolic effects of once daily extended-release metformin in patients with type 2 diabetes: a multicentre study[J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,2008,62(5):695-700.
APA Gao, H..,Xiao, W..,Wang, C..,Zhang, J..,Yang, Y..,...&Hong, T..(2008).The metabolic effects of once daily extended-release metformin in patients with type 2 diabetes: a multicentre study.INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,62(5),695-700.
MLA Gao, H.,et al."The metabolic effects of once daily extended-release metformin in patients with type 2 diabetes: a multicentre study".INTERNATIONAL JOURNAL OF CLINICAL PRACTICE 62.5(2008):695-700.
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