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学科主题基础医学
Developmental pathway of CD4(+)CD8(-) medullary thymocytes during mouse ontogeny and its defect in Aire(-/-) mice
Li, Juan; Li, Yan; Yao, Jin-Yan; Jin, Rong; Zhu, Ming-Zhao; Qian, Xiao-Ping; Zhang, Jun; Fu, Yang-Xin; Wu, Li; Zhang, Yu; Chen, Wei-Feng
关键词Relb T cell differentiation thymic medulla
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2007-11-13
DOI10.1073/pnas.0708884104
104期:46页:18175-18180
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]T-CELL DEVELOPMENT ; LYMPHOKINE SECRETION ; NEGATIVE SELECTION ; CENTRAL TOLERANCE ; FOXP3 EXPRESSION ; SELF-TOLERANCE ; RELB-DEFICIENT ; THYMIC STROMA ; AIRE ; MATURATION
英文摘要

The newly generated single-positive (SP) thymocytes undergo further maturation in the thymic medulla before their emigration to the periphery. The present study was undertaken to validate a developmental program we proposed for CD4SP medullary thymocytes and to explore the mechanisms regulating this process. During mouse ontogeny, the emergence of different subsets of CD4SP thymocytes followed a strict temporal order from SP1 to SP4. Parallel to the transition in surface phenotype, a steady increase in function was observed. As further evidence, purified SP1 cells were able to sequentially give rise to SP2, SP3, and SP4 cells in intrathymic adoptive transfer and in culture. Notably, the development of CD4SP cells in the medulla seemed to be critically dependent on a functionally intact medullary epithelial cell compartment because Relb and Aire deficiency were found to cause severe blockage at the transition from SP3 to SP4. Taken together, this work establishes an ontogenetically and functionally relevant maturation program for CD4SP thymocyrtes. Precise dissection of this program should facilitate further inquiry into the molecular mechanisms governing normal thymocyte development and its disturbance in pathological conditions.

语种英语
WOS记录号WOS:000251077000051
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被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/66822
专题北京大学基础医学院_免疫学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
2.Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
3.Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
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Li, Juan,Li, Yan,Yao, Jin-Yan,et al. Developmental pathway of CD4(+)CD8(-) medullary thymocytes during mouse ontogeny and its defect in Aire(-/-) mice[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2007,104(46):18175-18180.
APA Li, Juan.,Li, Yan.,Yao, Jin-Yan.,Jin, Rong.,Zhu, Ming-Zhao.,...&Chen, Wei-Feng.(2007).Developmental pathway of CD4(+)CD8(-) medullary thymocytes during mouse ontogeny and its defect in Aire(-/-) mice.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,104(46),18175-18180.
MLA Li, Juan,et al."Developmental pathway of CD4(+)CD8(-) medullary thymocytes during mouse ontogeny and its defect in Aire(-/-) mice".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104.46(2007):18175-18180.
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