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学科主题: 基础医学
题名:
Developmental pathway of CD4(+)CD8(-) medullary thymocytes during mouse ontogeny and its defect in Aire(-/-) mice
作者: Li, Juan; Li, Yan; Yao, Jin-Yan; Jin, Rong; Zhu, Ming-Zhao; Qian, Xiao-Ping; Zhang, Jun; Fu, Yang-Xin; Wu, Li; Zhang, Yu; Chen, Wei-Feng
关键词: Relb ; T cell differentiation ; thymic medulla
刊名: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
发表日期: 2007-11-13
DOI: 10.1073/pnas.0708884104
卷: 104, 期:46, 页:18175-18180
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: T-CELL DEVELOPMENT ; LYMPHOKINE SECRETION ; NEGATIVE SELECTION ; CENTRAL TOLERANCE ; FOXP3 EXPRESSION ; SELF-TOLERANCE ; RELB-DEFICIENT ; THYMIC STROMA ; AIRE ; MATURATION
英文摘要:

The newly generated single-positive (SP) thymocytes undergo further maturation in the thymic medulla before their emigration to the periphery. The present study was undertaken to validate a developmental program we proposed for CD4SP medullary thymocytes and to explore the mechanisms regulating this process. During mouse ontogeny, the emergence of different subsets of CD4SP thymocytes followed a strict temporal order from SP1 to SP4. Parallel to the transition in surface phenotype, a steady increase in function was observed. As further evidence, purified SP1 cells were able to sequentially give rise to SP2, SP3, and SP4 cells in intrathymic adoptive transfer and in culture. Notably, the development of CD4SP cells in the medulla seemed to be critically dependent on a functionally intact medullary epithelial cell compartment because Relb and Aire deficiency were found to cause severe blockage at the transition from SP3 to SP4. Taken together, this work establishes an ontogenetically and functionally relevant maturation program for CD4SP thymocyrtes. Precise dissection of this program should facilitate further inquiry into the molecular mechanisms governing normal thymocyte development and its disturbance in pathological conditions.

语种: 英语
WOS记录号: WOS:000251077000051
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66822
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
2.Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
3.Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Recommended Citation:
Li, Juan,Li, Yan,Yao, Jin-Yan,et al. Developmental pathway of CD4(+)CD8(-) medullary thymocytes during mouse ontogeny and its defect in Aire(-/-) mice[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2007,104(46):18175-18180.
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