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IR@PKUHSC  > 北京大学第二临床医学院  > 耳鼻喉科  > 期刊论文
学科主题: 临床医学
题名:
Transplantation of adipose-derived stem cells combined with decellularized cartilage ECM: A novel approach to nasal septum perforation repair
作者: Wang, Menghang1,2; Yu, Lisheng3
刊名: MEDICAL HYPOTHESES
发表日期: 2014-06-01
DOI: 10.1016/j.mehy.2014.03.025
卷: 82, 期:6, 页:781-783
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: REGENERATIVE MEDICINE ; DIFFERENTIATION ; APOPTOSIS ; MODEL
英文摘要:

Nasal septal perforation, a defect of the nasal mucoperichondrium and cartilage, may induce epistaxis, persistent rhinorrhea and nasal obstruction. Cell-based tissue engineering is a promising therapeutic method for the treatment of nasal septal perforation. However, lack of an adequate source of cells and unsuitable biomaterials greatly hinder the development of cell-based therapy. In this paper, we proposed the application of adipose-derived stem cells combined with decellularized cartilage ECM as a potential graft for the damaged nasal septum, which could help to repair the mucosal and cartilage tissues in the treatment of nasal septal perforation. This new technology could play a novel role in the repair of nasal septal perforation, and in regeneration of damaged nasal cartilage. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 11202018 ; 81170905 ; 20110490269 ; 2013T60055 ; 20091015
项目资助者: National Natural Scientific Foundation of China (NSFC) ; Postdoctoral Science Foundation of China ; Capital Medical Development Foundation
WOS记录号: WOS:000336704200030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66823
Appears in Collections:北京大学第二临床医学院_耳鼻喉科_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Int Hosp, Dept Otolaryngol, Beijing 102206, Peoples R China
2.Beihang Univ, Sch Biol Sci & Med Engn, Minist Educ, Key Lab Biomech & Mech, Beijing, Peoples R China
3.Peking Univ, Peking Univ Peoples Hosp, Dept Otolaryngol, Beijing 100044, Peoples R China

Recommended Citation:
Wang, Menghang,Yu, Lisheng. Transplantation of adipose-derived stem cells combined with decellularized cartilage ECM: A novel approach to nasal septum perforation repair[J]. MEDICAL HYPOTHESES,2014,82(6):781-783.
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