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学科主题临床医学
Transplantation of adipose-derived stem cells combined with decellularized cartilage ECM: A novel approach to nasal septum perforation repair
Wang, Menghang1,2; Yu, Lisheng3
刊名MEDICAL HYPOTHESES
2014-06-01
DOI10.1016/j.mehy.2014.03.025
82期:6页:781-783
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]REGENERATIVE MEDICINE ; DIFFERENTIATION ; APOPTOSIS ; MODEL
英文摘要

Nasal septal perforation, a defect of the nasal mucoperichondrium and cartilage, may induce epistaxis, persistent rhinorrhea and nasal obstruction. Cell-based tissue engineering is a promising therapeutic method for the treatment of nasal septal perforation. However, lack of an adequate source of cells and unsuitable biomaterials greatly hinder the development of cell-based therapy. In this paper, we proposed the application of adipose-derived stem cells combined with decellularized cartilage ECM as a potential graft for the damaged nasal septum, which could help to repair the mucosal and cartilage tissues in the treatment of nasal septal perforation. This new technology could play a novel role in the repair of nasal septal perforation, and in regeneration of damaged nasal cartilage. (C) 2014 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000336704200030
项目编号11202018 ; 81170905 ; 20110490269 ; 2013T60055 ; 20091015
资助机构National Natural Scientific Foundation of China (NSFC) ; Postdoctoral Science Foundation of China ; Capital Medical Development Foundation
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66823
专题北京大学第二临床医学院_耳鼻喉科
作者单位1.Peking Univ, Peking Univ Int Hosp, Dept Otolaryngol, Beijing 102206, Peoples R China
2.Beihang Univ, Sch Biol Sci & Med Engn, Minist Educ, Key Lab Biomech & Mech, Beijing, Peoples R China
3.Peking Univ, Peking Univ Peoples Hosp, Dept Otolaryngol, Beijing 100044, Peoples R China
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GB/T 7714
Wang, Menghang,Yu, Lisheng. Transplantation of adipose-derived stem cells combined with decellularized cartilage ECM: A novel approach to nasal septum perforation repair[J]. MEDICAL HYPOTHESES,2014,82(6):781-783.
APA Wang, Menghang,&Yu, Lisheng.(2014).Transplantation of adipose-derived stem cells combined with decellularized cartilage ECM: A novel approach to nasal septum perforation repair.MEDICAL HYPOTHESES,82(6),781-783.
MLA Wang, Menghang,et al."Transplantation of adipose-derived stem cells combined with decellularized cartilage ECM: A novel approach to nasal septum perforation repair".MEDICAL HYPOTHESES 82.6(2014):781-783.
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