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学科主题: 医学信息学
题名:
Identification of long non-protein coding RNAs in chicken skeletal muscle using next generation sequencing
作者: Li, Tingting1,2; Wang, Suya1; Wu, Rimao1; Zhou, Xueya3,4; Zhu, Dahai1; Zhang, Yong1
关键词: IncRNAs ; RNA-seq ; Computational pipeline ; Chicken skeletal muscle
刊名: GENOMICS
发表日期: 2012-05-01
DOI: 10.1016/j.ygeno.2012.02.003
卷: 99, 期:5, 页:292-298
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity
研究领域[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]: NONCODING RNAS ; GENOME ; EXPRESSION ; GENES ; DIFFERENTIATION ; TRANSCRIPTS ; ANNOTATION ; VERTEBRATE ; MICRORNAS ; REVEALS
英文摘要:

Vertebrate genomes encode thousands of non-coding RNAs including short non-coding RNAs (such as microRNAs) and long non-coding RNAs (IncRNAs). Chicken (Gallus gallus) is an important model organism for developmental biology, and the recently assembled genome sequences for chicken will facilitate the understanding of the functional roles of non-coding RNA genes during development. The present study concerns the first systematic identification of IncRNAs using RNA-Seq to sample the transcriptome during chicken muscle development. A computational approach was used to identify 281 new intergenic IncRNAs in the chicken genome. Novel IncRNAs in general are less conserved than protein-coding genes and slightly more conserved than random non-coding sequences. The present study has provided an initial chicken IncRNA catalog and greatly increased the number of chicken ncRNAs in the non-protein coding RNA database. Furthermore, the computational pipeline presented in the current work will be useful for characterizing IncRNAs obtained from deep sequencing data. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2011CBA01104 ; 2007CB946903 ; 2009CB941602 ; 2009CB825403 ; 31030041 ; 91019010 ; 30871248 ; 60905014
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000304636100004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66827
Appears in Collections:基础医学院_医学信息学系_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Sch Basic Med,Peking Union Med Coll, Beijing 100005, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biomed Informat, Beijing 100191, Peoples R China
3.Tsinghua Univ, MOE Key Lab Bioinformat, TNUST, Dept Automat, Beijing 100084, Peoples R China
4.Tsinghua Univ, Bioinformat Div, TNUST, Dept Automat, Beijing 100084, Peoples R China

Recommended Citation:
Li, Tingting,Wang, Suya,Wu, Rimao,et al. Identification of long non-protein coding RNAs in chicken skeletal muscle using next generation sequencing[J]. GENOMICS,2012,99(5):292-298.
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