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学科主题医学信息学
Identification of long non-protein coding RNAs in chicken skeletal muscle using next generation sequencing
Li, Tingting1,2; Wang, Suya1; Wu, Rimao1; Zhou, Xueya3,4; Zhu, Dahai1; Zhang, Yong1
关键词IncRNAs RNA-seq Computational pipeline Chicken skeletal muscle
刊名GENOMICS
2012-05-01
DOI10.1016/j.ygeno.2012.02.003
99期:5页:292-298
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]NONCODING RNAS ; GENOME ; EXPRESSION ; GENES ; DIFFERENTIATION ; TRANSCRIPTS ; ANNOTATION ; VERTEBRATE ; MICRORNAS ; REVEALS
英文摘要

Vertebrate genomes encode thousands of non-coding RNAs including short non-coding RNAs (such as microRNAs) and long non-coding RNAs (IncRNAs). Chicken (Gallus gallus) is an important model organism for developmental biology, and the recently assembled genome sequences for chicken will facilitate the understanding of the functional roles of non-coding RNA genes during development. The present study concerns the first systematic identification of IncRNAs using RNA-Seq to sample the transcriptome during chicken muscle development. A computational approach was used to identify 281 new intergenic IncRNAs in the chicken genome. Novel IncRNAs in general are less conserved than protein-coding genes and slightly more conserved than random non-coding sequences. The present study has provided an initial chicken IncRNA catalog and greatly increased the number of chicken ncRNAs in the non-protein coding RNA database. Furthermore, the computational pipeline presented in the current work will be useful for characterizing IncRNAs obtained from deep sequencing data. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000304636100004
项目编号2011CBA01104 ; 2007CB946903 ; 2009CB941602 ; 2009CB825403 ; 31030041 ; 91019010 ; 30871248 ; 60905014
资助机构National Basic Research Program of China ; National Natural Science Foundation of China
引用统计
被引频次:69[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66827
专题北京大学基础医学院_医学信息学系
北京大学基础医学院
作者单位1.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Sch Basic Med,Peking Union Med Coll, Beijing 100005, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biomed Informat, Beijing 100191, Peoples R China
3.Tsinghua Univ, MOE Key Lab Bioinformat, TNUST, Dept Automat, Beijing 100084, Peoples R China
4.Tsinghua Univ, Bioinformat Div, TNUST, Dept Automat, Beijing 100084, Peoples R China
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GB/T 7714
Li, Tingting,Wang, Suya,Wu, Rimao,et al. Identification of long non-protein coding RNAs in chicken skeletal muscle using next generation sequencing[J]. GENOMICS,2012,99(5):292-298.
APA Li, Tingting,Wang, Suya,Wu, Rimao,Zhou, Xueya,Zhu, Dahai,&Zhang, Yong.(2012).Identification of long non-protein coding RNAs in chicken skeletal muscle using next generation sequencing.GENOMICS,99(5),292-298.
MLA Li, Tingting,et al."Identification of long non-protein coding RNAs in chicken skeletal muscle using next generation sequencing".GENOMICS 99.5(2012):292-298.
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