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学科主题: 临床医学
题名:
Pathologic fracture does not influence local recurrence and survival in high-grade extremity osteosarcoma with adequate surgical margins
作者: Xie, Lu; Guo, Wei; Li, Yuanbo; Ji, Tao; Sun, Xin
关键词: pathologic fracture ; osteosarcoma ; limb salvage surgery ; survival
刊名: JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2012-12-01
DOI: 10.1002/jso.23150
卷: 106, 期:7, 页:820-825
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: LIMB SALVAGE ; CHEMOTHERAPY ; SARCOMAS
英文摘要:

Background and Objectives: The purpose of this study was to estimate the risk factors having relationships with pathologic fracture of osteosarcoma of extremities and to evaluate the role of limb salvage surgery in this group of patients.

Methods: We retrospectively analyzed 28 consecutive cases of pathologic fracture of primary high-grade localized osteosarcoma of extremities between June 1, 2001 and June 30, 2009. All patients underwent limb salvage surgery and neo-adjuvant chemotherapy. They had a median age of 14 years (range, 630 years). The average follow-up time was 40.7 months (range, 9108 months). Clinicopathological factors were analyzed in relation to pathologic fracture. Their recurrence and survival rates were compared to those in cohort of 171 osteosarcoma patients without pathologic fracture who underwent limb salvage surgery during the same period at the same institution.

Results: Less than 15 years, telangiectatic histological subtype, tumor located at the proximal humerus, and radiographical manifested as osteolytic features were risk factors in relation to pathologic fracture. The overall 3- and 5-year survival rates were 50.5% and 45.4%, respectively, in the fracture group, and were not significantly different from those in the control group (71.0% and 61.9%, respectively). Of all 28 fracture patients, 4 experienced local recurrences (14.2%) and 14 developed distant metastasis (50%), which were not significantly different from the rates in the control group (8.8% and 37.4%, respectively).

Conclusion: Limb salvage surgery with adequate margins combined with neo-adjuvant chemotherapy for pathologic fracture of osteosarcoma did not seem to significantly increase the risk of local recurrence or distal metastasis. J. Surg. Oncol. 2012; 106:820825. (C) 2012 Wiley Periodicals, Inc.

语种: 英语
项目资助者: Beijing Natural Science Foundation
WOS记录号: WOS:000310541900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66831
Appears in Collections:北京大学第二临床医学院_骨肿瘤科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100044, Peoples R China

Recommended Citation:
Xie, Lu,Guo, Wei,Li, Yuanbo,et al. Pathologic fracture does not influence local recurrence and survival in high-grade extremity osteosarcoma with adequate surgical margins[J]. JOURNAL OF SURGICAL ONCOLOGY,2012,106(7):820-825.
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