IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
In vitro antifungal susceptibility of Trichophyton violaceum isolated from tinea capitis patients
Deng, S.1,2,3; de Hoog, G. S.3,4,5,6,7; Verweij, P. E.8; Zoll, J.8; Ilkit, M.9; Morsali, F.10; Abliz, P.2; Wang, X.2; Zhan, P.3; Yang, L.3; Hasimu, H.2; Liao, W.1; Pan, W.1; Seyedmousavi, S.8,10,11,12
关键词T. violaceum antifungal susceptibility testing fungus
刊名JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
2015-04-01
DOI10.1093/jac/dku503
70期:4页:1072-1075
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]CLINICAL-TRIAL ; WESTERN CHINA ; DERMATOPHYTES ; GRISEOFULVIN ; TERBINAFINE ; FLUCONAZOLE ; DRUGS
英文摘要

Objectives: Trichophyton violaceum is an anthropophilic dermatophyte that is endemic to parts of Africa and Asia and is sporadic in Europe. T. violaceum mainly causes tinea capitis in both children and adolescents. Although the infections caused by T. violaceum are of considerable medical importance, its antifungal susceptibility profile remains poorly examined.

Methods: In this study, we tested the in vitro antifungal susceptibility of a set of clinical T. violaceum isolates obtained from tinea capitis patients, using the CLSI broth microdilution method. We tested eight antifungals and used isolates collected from Western China (21), Eastern China (12), the Middle East (1), Europe (20), South Africa (7) and Canada (1).

Results: The geometric means of the MICs of the antifungals for all isolates were as follows (in increasing order): posaconazole, 0.021 mg/L; terbinafine, 0.023 mg/L; voriconazole, 0.062 mg/L; amphotericin B, 0.20 mg/L; itraconazole, 0.34 mg/L; caspofungin, 0.56 mg/L; fluconazole, 4.23 mg/L; and flucytosine, 8.46 mg/L. No statistically significant differences in the susceptibility profiles of T. violaceum were detected within the geographical regions tested.

Conclusions: Posaconazole, terbinafine and voriconazole were shown to be the most potent antifungal agents against T. violaceum isolates obtained from tinea capitis patients worldwide. These results might help clinicians in developing appropriate therapies that have a high probability of successfully treating tinea capitis due to T. violaceum.

语种英语
WOS记录号WOS:000354708600017
项目编号2013CB531601 ; 2013CB531606 ; 2013ZX10004612 ; 2012211A063
资助机构Program 973 ; Fund of Severe Infectious Disease of China ; Xinjiang Nature Science Fund of China ; CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands ; Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands ; Department of Medical Mycology and Parasitology, Faculty of Medicine and Medical Sciences, Islamic Azad University, Ardabil Branch, Ardabil, Iran
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66836
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Xinjiang Med Univ, Hosp 1, Urumqi, Peoples R China
2.CBS KNAW Fungal Biodivers Ctr, Utrecht, Netherlands
3.King Abdulaziz Univ, Jeddah 21413, Saudi Arabia
4.Radboudumc, Dept Med Microbiol, Nijmegen, Netherlands
5.Mazandaran Univ Med Sci, Invas Fungi Res Ctr, Sari, Iran
6.Second Mil Med Univ, Changzheng Hosp, Shanghai Inst Med Mycol, Shanghai, Peoples R China
7.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
8.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
9.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
10.Cukurova Univ, Fac Med, Dept Microbiol, Div Mycol, Adana, Turkey
11.Islamic Azad Univ, Ardabil Branch, Dept Med Mycol & Parasitol, Fac Med & Med Sci, Ardebil, Iran
12.Erasmus MC, Dept Med Microbiol & Infect Dis, NL-3000 CA Rotterdam, Netherlands
推荐引用方式
GB/T 7714
Deng, S.,de Hoog, G. S.,Verweij, P. E.,et al. In vitro antifungal susceptibility of Trichophyton violaceum isolated from tinea capitis patients[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,2015,70(4):1072-1075.
APA Deng, S..,de Hoog, G. S..,Verweij, P. E..,Zoll, J..,Ilkit, M..,...&Seyedmousavi, S..(2015).In vitro antifungal susceptibility of Trichophyton violaceum isolated from tinea capitis patients.JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,70(4),1072-1075.
MLA Deng, S.,et al."In vitro antifungal susceptibility of Trichophyton violaceum isolated from tinea capitis patients".JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 70.4(2015):1072-1075.
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