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学科主题: 临床医学
题名:
In vitro antifungal susceptibility of Trichophyton violaceum isolated from tinea capitis patients
作者: Deng, S.1,2,3; de Hoog, G. S.3,4,5,6,7; Verweij, P. E.8; Zoll, J.8; Ilkit, M.9; Morsali, F.10; Abliz, P.2; Wang, X.2; Zhan, P.3; Yang, L.3; Hasimu, H.2; Liao, W.1; Pan, W.1; Seyedmousavi, S.8,10,11,12
关键词: T. violaceum ; antifungal susceptibility testing ; fungus
刊名: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
发表日期: 2015-04-01
DOI: 10.1093/jac/dku503
卷: 70, 期:4, 页:1072-1075
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]: CLINICAL-TRIAL ; WESTERN CHINA ; DERMATOPHYTES ; GRISEOFULVIN ; TERBINAFINE ; FLUCONAZOLE ; DRUGS
英文摘要:

Objectives: Trichophyton violaceum is an anthropophilic dermatophyte that is endemic to parts of Africa and Asia and is sporadic in Europe. T. violaceum mainly causes tinea capitis in both children and adolescents. Although the infections caused by T. violaceum are of considerable medical importance, its antifungal susceptibility profile remains poorly examined.

Methods: In this study, we tested the in vitro antifungal susceptibility of a set of clinical T. violaceum isolates obtained from tinea capitis patients, using the CLSI broth microdilution method. We tested eight antifungals and used isolates collected from Western China (21), Eastern China (12), the Middle East (1), Europe (20), South Africa (7) and Canada (1).

Results: The geometric means of the MICs of the antifungals for all isolates were as follows (in increasing order): posaconazole, 0.021 mg/L; terbinafine, 0.023 mg/L; voriconazole, 0.062 mg/L; amphotericin B, 0.20 mg/L; itraconazole, 0.34 mg/L; caspofungin, 0.56 mg/L; fluconazole, 4.23 mg/L; and flucytosine, 8.46 mg/L. No statistically significant differences in the susceptibility profiles of T. violaceum were detected within the geographical regions tested.

Conclusions: Posaconazole, terbinafine and voriconazole were shown to be the most potent antifungal agents against T. violaceum isolates obtained from tinea capitis patients worldwide. These results might help clinicians in developing appropriate therapies that have a high probability of successfully treating tinea capitis due to T. violaceum.

语种: 英语
所属项目编号: 2013CB531601 ; 2013CB531606 ; 2013ZX10004612 ; 2012211A063
项目资助者: Program 973 ; Fund of Severe Infectious Disease of China ; Xinjiang Nature Science Fund of China ; CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands ; Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands ; Department of Medical Mycology and Parasitology, Faculty of Medicine and Medical Sciences, Islamic Azad University, Ardabil Branch, Ardabil, Iran
WOS记录号: WOS:000354708600017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66836
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Xinjiang Med Univ, Hosp 1, Urumqi, Peoples R China
2.CBS KNAW Fungal Biodivers Ctr, Utrecht, Netherlands
3.King Abdulaziz Univ, Jeddah 21413, Saudi Arabia
4.Radboudumc, Dept Med Microbiol, Nijmegen, Netherlands
5.Mazandaran Univ Med Sci, Invas Fungi Res Ctr, Sari, Iran
6.Second Mil Med Univ, Changzheng Hosp, Shanghai Inst Med Mycol, Shanghai, Peoples R China
7.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
8.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
9.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
10.Cukurova Univ, Fac Med, Dept Microbiol, Div Mycol, Adana, Turkey
11.Islamic Azad Univ, Ardabil Branch, Dept Med Mycol & Parasitol, Fac Med & Med Sci, Ardebil, Iran
12.Erasmus MC, Dept Med Microbiol & Infect Dis, NL-3000 CA Rotterdam, Netherlands

Recommended Citation:
Deng, S.,de Hoog, G. S.,Verweij, P. E.,et al. In vitro antifungal susceptibility of Trichophyton violaceum isolated from tinea capitis patients[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,2015,70(4):1072-1075.
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