IR@PKUHSC  > 中国药物依赖性研究所
学科主题药物依赖
Nicotine dependence and serum BDNF levels in male patients with schizophrenia
Zhang, Xiang Yang1,2,4; Xiu, Mei Hong2; Chen, Da Chun2; Yang, Fu De2; Wu, Gui Ying4; Lu, Lin3; Kosten, Therese A.4; Kosten, Thomas R.1,4
关键词Schizophrenia Smoking Nicotine Brain-derived neurotrophic factor Neurotrophin
刊名PSYCHOPHARMACOLOGY
2010-10-01
DOI10.1007/s00213-010-1956-y
212期:3页:301-307
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
资助者Stanley Medical Research Institute ; Department of Veterans Affairs ; US National Institute of Health ; VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC) ; Stanley Medical Research Institute ; Department of Veterans Affairs ; US National Institute of Health ; VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC)
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]NEUROTROPHIC FACTOR BDNF ; FACTOR MESSENGER-RNA ; LONG-TERM TREATMENT ; RAT-BRAIN ; EXPERIMENTAL PARKINSONISM ; STRIATAL INCREASE ; BIPOLAR DISORDER ; DECREASED LEVELS ; KNOCKOUT MICE ; SMOKING
英文摘要

Schizophrenia is associated with a significantly high prevalence of smoking. Upregulation of neurotrophins by nicotine is well established. Accumulating evidence shows that brain-derived neurotrophic factor (BDNF) may be involved in the pathophysiology of schizophrenia. The purposes of this study were to compare BDNF levels in smokers to nonsmokers with schizophrenia and examine the association between BDNF levels and psychopathological symptoms.

Serum BDNF levels were measured in 139 male inpatients with DSM-IV schizophrenia: 102 smokers and 37 nonsmokers. Symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS).

The positive PANSS symptoms were lower in smokers than in nonsmokers, while the negative symptoms were lower in those who smoked more cigarettes. BDNF levels were significantly higher in smokers than in nonsmokers (p < 0.05). Higher BDNF levels correlated with fewer negative symptoms and with smoking more cigarettes.

The fewer positive symptoms in smokers and fewer negative symptoms in those who smoked more cigarettes may be associated with nicotine-induced upregulation of BDNF.

语种英语
所属项目编号03T-459 ; 05T-726 ; K05-DA0454 ; P50-DA18827 ; U01-MH79639
资助者Stanley Medical Research Institute ; Department of Veterans Affairs ; US National Institute of Health ; VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC) ; Stanley Medical Research Institute ; Department of Veterans Affairs ; US National Institute of Health ; VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC)
WOS记录号WOS:000282828100002
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66838
专题中国药物依赖性研究所
作者单位1.VA Med Ctr, Houston, TX 77030 USA
2.Beijing HuiLongGuan Hosp, Ctr Biol Psychiat, Beijing 100096, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
4.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
推荐引用方式
GB/T 7714
Zhang, Xiang Yang,Xiu, Mei Hong,Chen, Da Chun,et al. Nicotine dependence and serum BDNF levels in male patients with schizophrenia[J]. PSYCHOPHARMACOLOGY,2010,212(3):301-307.
APA Zhang, Xiang Yang.,Xiu, Mei Hong.,Chen, Da Chun.,Yang, Fu De.,Wu, Gui Ying.,...&Kosten, Thomas R..(2010).Nicotine dependence and serum BDNF levels in male patients with schizophrenia.PSYCHOPHARMACOLOGY,212(3),301-307.
MLA Zhang, Xiang Yang,et al."Nicotine dependence and serum BDNF levels in male patients with schizophrenia".PSYCHOPHARMACOLOGY 212.3(2010):301-307.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Xiang Yang]的文章
[Xiu, Mei Hong]的文章
[Chen, Da Chun]的文章
百度学术
百度学术中相似的文章
[Zhang, Xiang Yang]的文章
[Xiu, Mei Hong]的文章
[Chen, Da Chun]的文章
必应学术
必应学术中相似的文章
[Zhang, Xiang Yang]的文章
[Xiu, Mei Hong]的文章
[Chen, Da Chun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。