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学科主题: 临床医学
题名:
Investigating urachal carcinoma for more than 15 years
作者: Chen, Duqun1,2,3; Li, Yifan1,2,3; Yu, Zuhu1,2,3; Su, Zhengming2,3,4; Ni, Liangchao2,3; Gui, Yaoting2,3; Yang, Shangqi2,3; Shi, Bentao2,3,5; Lai, Yongqing2,3
关键词: urachal carcinoma ; survival ; tumor grade
刊名: ONCOLOGY LETTERS
发表日期: 2014-11-01
DOI: 10.3892/ol.2014.2502
卷: 8, 期:5, 页:2279-2283
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SURVIVAL ; OUTCOMES ; CANCER
英文摘要:

Urachal carcinomas are rare bladder malignances, which usually present at an advanced stage with a high risk of distant metastases and a poor prognosis. To improve understanding of this uncommon carcinoma, a retrospective review was conducted for the cases observed at Peking University Shenzhen Hospital and Peking University First Hospital. The clinical outcomes were analyzed for 17 patients with a diagnosis of urachal cancer, who were admitted to Peking University Shenzhen Hospital (Shenzhen, China) and Peking University First Hospital (Beijing, China) between 1998 and 2013. The TNM staging system was used to predict outcomes. Among the 17 study patients, there were 10 males and seven females, with a median age at diagnosis of 50 years. A total of four (23%) patients presented with lymph node or distant metastasis. The median overall survival time for all stages was 57.6 months, with five patients (38.4%) alive for more than five years following treatment. The application of the TNM staging system demonstrated a median survival time of 6.2 years for stage I/II patients, compared with a median survival of 1.8 years (log-rank, P<0.001) for patients with advanced disease (stages III and IV). In addition, no significant correlation was observed between tumor size and age, and survival. In conclusion, urachal carcinomas are usually locally advanced at presentation. Surgical excision remains the predominant choice of treatment and lymph node dissection is not required unless lymph node involvement is confirmed by preoperative examination. The current results indicated that the most significant predictor of prognosis was the tumor grade.

语种: 英语
所属项目编号: 81101922 ; A2012584 ; A2013606 ; JCYJ20130402114702124
项目资助者: National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen
WOS记录号: WOS:000344424300072
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66839
Appears in Collections:北京大学深圳医院_泌尿外科_期刊论文

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作者单位: 1.Anhui Med Univ, Dept Urol, Hefei 230032, Anhui, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen PKU HKUST Med Ctr,Inst Urol, Shenzhen 518036, Guangdong, Peoples R China
4.Shantou Univ, Coll Med, Dept Urol, Shantou 515041, Guangdong, Peoples R China
5.Peking Univ, Inst Urol, Dept Urol, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Chen, Duqun,Li, Yifan,Yu, Zuhu,et al. Investigating urachal carcinoma for more than 15 years[J]. ONCOLOGY LETTERS,2014,8(5):2279-2283.
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