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学科主题: 基础医学
题名:
3-Hydroxyphthalic Anhydride-Modified Chicken Ovalbumin Exhibits Potent and Broad Anti-HIV-1 Activity: a Potential Microbicide for Preventing Sexual Transmission of HIV-1
作者: Li, Lin1,2; He, Lili2; Tan, Suiyi1,2; Guo, Xinhua1; Lu, Hong1; Qi, Zhi1; Pan, Chungen1; An, Xiuli1,3; Jiang, Shibo1,2; Liu, Shuwen2
刊名: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
发表日期: 2010-05-01
DOI: 10.1128/AAC.01046-09
卷: 54, 期:5, 页:1700-1711
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]: Microbiology ; Pharmacology & Pharmacy
关键词[WOS]: CELLULOSE-ACETATE 1,2-BENZENEDICARBOXYLATE ; GENITAL HERPESVIRUS-INFECTION ; NONOXYNOL-9 VAGINAL GEL ; VIRUS TYPE-1 INFECTION ; IN-VITRO ; BETA-LACTOGLOBULIN ; TOPICAL MICROBICIDES ; ANTIVIRAL ACTIVITY ; ENVELOPE GLYCOPROTEIN ; MUCOSAL TRANSMISSION
英文摘要:

Heterosexual transmission is the primary route by which women acquire human immunodeficiency virus (HIV)/AIDS. Thus, development of woman-controlled topical microbicides for prevention of sexual transmission of HIV is urgently needed. Here we report that 3-hydroxyphthalic anhydride-modified chicken ovalbumin (HP-OVA) exhibits potent antiviral activity against a broad spectrum of human immunodeficiency virus type 1 (HIV-1) isolates with different genotypes and biotypes. Its antiviral activity is correlated with the percentages of the chemically modified and unmodified lysines and arginines in OVA. HP-OVA inhibits HIV-1 fusion and entry through multiple mechanisms of action, including (i) blocking gp120 binding to CD4 and (ii) interfering with gp41 six-helix bundle formation. Because of the widespread availability and established safety profile of OVA, HP-OVA has good potential to be developed as an effective, safe, and affordable microbicide for prevention of HIV sexual transmission.

语种: 英语
所属项目编号: U19 AI076964 ; U0832001 ; 30729001 ; 30801412 ; 2008ZX10001-015 ; 2005CB523100
项目资助者: NIH ; Natural Science Foundation of China ; National Key Project
WOS记录号: WOS:000276804300007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66840
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10065 USA
2.So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100871, Peoples R China

Recommended Citation:
Li, Lin,He, Lili,Tan, Suiyi,et al. 3-Hydroxyphthalic Anhydride-Modified Chicken Ovalbumin Exhibits Potent and Broad Anti-HIV-1 Activity: a Potential Microbicide for Preventing Sexual Transmission of HIV-1[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2010,54(5):1700-1711.
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