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Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium
Toporcov, Tatiana Natasha1; Znaor, Ariana2; Zhang, Zuo-Feng3; Yu, Guo-Pei4,5; Winn, Deborah M.6; Wei, Qingyi7; Vilensky, Marta8; Vaughan, Thomas9,15; Thomson, Peter10; Talamini, Renato11; Szeszenia-Dabrowska, Neonila12; Sturgis, Erich M.7; Smith, Elaine13; Shangina, Oxana14; Schwartz, Stephen M.9,15; Schantz, Stimson16; Rudnai, Peter17; Richiardi, Lorenzo18; Ramroth, Heribert19; Purdue, Mark P.6; Olshan, Andrew F.20; Eluf-Neto, Jose21; Muscat, Joshua22; Moyses, Raquel Ajub23; Morgenstern, Hal24,25,26; Menezes, Ana27; McClean, Michael28; Matsuo, Keitaro29; Mates, Dana30; Macfarlane, Tatiana V.31; Lissowska, Jolanta32,33; Levi, Fabio34,35; Lazarus, Philip36; La Vecchia, Carlo37,38; Lagiou, Pagona39; Koifman, Sergio40; Kjaerheim, Kristina41; Kelsey, Karl42; Holcatova, Ivana43; Herrero, Rolando44; Healy, Claire45; Hayes, Richard B.46; Franceschi, Silvia47; Fernandez, Leticia48; Fabianova, Eleonora49; Daudt, Alexander W.50; Curioni, Otavio Alberto51; Dal Maso, Luigino11; Curado, Maria Paula52; Conway, David I.53; Chen, Chu; Castellsague, Xavier54; Canova, Cristina55; Cadoni, Gabriella56; Brennan, Paul50; Boccia, Stefania57; Antunes, Jose Leopoldo Ferreira1; Ahrens, Wolfgang58,59; Agudo, Antonio60; Boffetta, Paolo61; Hashibe, Mia62; Lee, Yuan-Chin Amy63; Wuensch Filho, Victor1
关键词Head and neck neoplasms adult smoking alcohol drinking diet
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
研究领域[WOS]Public, Environmental & Occupational Health

Background: Increasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients.

Methods: We pooled data from 25 case-control studies and conducted separate analyses for adults <= 45 years old (′young adults′, 2010 cases and 4042 controls) and > 45 years old (′older adults′, 17 700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs).

Results: The young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, =19.9% (95% CI = 9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking = 5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR = 2.27 (95% CI = 1.26, 4.10)], but not in the older adults [OR = 1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2 .41%, 5.80%) in older adults.

Conclusions: Differences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.

项目编号R03CA113157 ; R03DE016611 ; KFS1069-09-2000 ; FOR381.88 ; AKT 617 ; 88D28 ; KFS-700 ; OCS-1633 ; IC15-CT98-0332 ; P01CA068384 K07CA104231 ; R01CA078609 ; R01CA100679 ; R01CA048996 ; R01DE012609 ; NIDCR R01DE11979 ; NIDCR R01DE13110 ; NIH FIRCA TW01500 ; R01CA61188 ; P01CA068384 ; K07CA104231 ; R01DE13158 ; P50CA90388 ; R01DA11386 ; R03CA77954 ; T32CA09142 ; U01CA96134 ; R21ES011667 ; R01ES11740 ; R01CA100264 ; R01CA51845 ; R01CA30022 ; P30ES010126 ; 01/01768-2 ; IC18-CT97-0222 ; FIS 97/0024 ; FIS 97/0662 ; BAE 01/5013 ; 10068 ; 04/12054-9 ; 10/51168-0 ; QLK1-CT-2001-00182 ; 01GB9702/3 ; 17015052 ; H20-002
资助机构US National Institutes of Health ; National Cancer Institute ; National Institute of Dental and Craniofacial Health ; Italian Association for Research on Cancer (AIRC) ; Italian League Against Cancer ; Italian Ministry of Research ; Swiss League against Cancer ; Fribourg League against Cancer ; Swiss Cancer Research ; Gustave-Roussy Institute ; Swiss League against Cancer ; Swiss Research against Cancer/Oncosuisse ; World Cancer Research Fund ; European Commission INCO-COPERNICUS Program ; National Institutes of Health (NIH) US ; NIH ; Veterans Affairs Merit Review Funds ; National Institute of Environmental Health Sciences ; Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center ; National Institutes of Health (NCI) US ; NIDCR intramural programmes ; Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina ; IMIM (Barcelona) ; Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP) ; European Commission ; IARC multicentre study: Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government ; International Union Against Cancer (UICC) ; Yamagiwa-Yoshida Memorial International Cancer Study Grant ; AIRC (Italian Agency for Research on Cancer) ; US multicentre study: the Intramural Program of the NCI, NIH, United States ; Sao Paulo study: Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP) ; European Community ; German Ministry of Education and Research ; Ministry of Education, Science, Sports, Culture and Technology of Japan ; Ministry of Health, Labour and Welfare of Japan
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
作者单位1.Canc Registry Norway, Oslo, Norway
2.Charles Univ Prague, Fac Med 1, Prague, Czech Republic
3.Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA
4.WHO, Int Agcy Res Canc, Prevent & Implementat Grp, Lyon, France
5.Trinity Coll Sch Dent Sci, Dublin, Ireland
6.NYU, Sch Med, Div Epidemiol, New York, NY USA
7.Int Agcy Res Canc, F-69372 Lyon, France
8.Inst Oncol & Radiobiol, Havana, Cuba
9.Int Prevent Res Inst, Lyon, France
10.Univ Sao Paulo, Fac Saude Publ, BR-01246904 Sao Paulo, SP, Brazil
11.Croatian Natl Canc Registry, Zagreb, Croatia
12.Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA
13.Peking Univ, Med Informat Ctr, Beijing 100871, Peoples R China
14.New York Med Coll, Valhalla, NY 10595 USA
15.NCI, Bethesda, MD 20892 USA
16.UT MD Anderson Canc Ctr, Houston, TX USA
17.Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF, Argentina
18.Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
19.Aviano Canc Ctr, I-33081 Aviano, Italy
20.Inst Occupat Med, Lodz, Poland
21.Univ Iowa, Coll Publ Hlth, Iowa City, IA USA
22.Russian Acad Med Sci, Canc Res Ctr, Moscow, Russia
23.Univ Newcastle, Sch Dent Sci, Newcastle Upon Tyne, Tyne & Wear, England
24.Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
25.New York Eye & Ear Infirm, New York, NY 10003 USA
26.Natl Inst Environm Hlth, Budapest, Hungary
27.Univ Turin, Canc Epidemiol Unit, Dept Med Sci, Turin, Italy
28.Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany
29.Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA
30.Univ Sao Paulo, Fac Med, Sao Paulo, Brazil
31.Penn State Coll Med, Hershey, PA USA
32.Univ Sao Paulo, Fac Med, Cirurgia Cabeca & Pescoco LIM 28, Sao Paulo, Brazil
33.Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
34.Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
35.Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
36.Univ Fed Pelotas, Pelotas, Brazil
37.CHU Vaudois, IUMSP, CH-1011 Lausanne, Switzerland
38.Ist Ric Farmacol Mario Negri, IRCCS, Milan, Italy
39.Fundacao Osvvaldo Cruz, Escola Nacl Saude Publ, Rio De Janeiro, Brazil
40.Reg Author Publ Hlth Banska Bystrica, Banska Bystrica, Slovakia
41.Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
42.Secretaria Estado Saude Sao Paulo, Hosp Heliopolis, Sao Paulo, Brazil
43.Univ Glasgow, Sch Dent, Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland
44.CIBER ESP, IDIBELL, ICO, Barcelona, Spain
45.Univ Padua, Padua, Italy
46.Univ Cattolica Sacro Cuore, Inst Otorhinolaryngol, Rome, Italy
47.Univ Cattolica Sacro Cuore, Inst Publ Hlth, Rome, Italy
48.BIPS, Leibniz Inst Prevent Res & Epidemiol, Bremen, Germany
49.Univ Bremen, Inst Stat, Fac Math & Comp Sci, D-28359 Bremen, Germany
50.IDIBELL, ICO, Barcelona, Spain
51.Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA
52.Univ Utah, Sch Med, Huntsnnan Canc Inst, Salt Lake City, UT USA
53.Univ Utah, Sch Med, Dept Family & Prevent Med, Div Publ Hlth, Salt Lake City, UT 84112 USA
54.Boston Univ, Sch Publ Hlth, Boston, MA USA
55.Aichi Canc Ctr, Res Inst, Nagoya, Aichi 464, Japan
56.Inst Publ Hlth, Bucharest, Romania
57.Univ Aberdeen, Sch Dent, Aberdeen, Scotland
58.M Skasodowska Curie Mem Canc Ctr, Warsaw, Poland
59.Inst Oncol, Dept Canc Epidemiol & Prevent, Warsaw, Poland
60.Univ Lausanne, Lausanne, Switzerland
61.Washington State Univ, Coll Pharm, Spokane, WA USA
62.Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy
63.Univ Athens, Sch Med, GR-11527 Athens, Greece
GB/T 7714
Toporcov, Tatiana Natasha,Znaor, Ariana,Zhang, Zuo-Feng,et al. Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium[J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,2015,44(1):169-185.
APA Toporcov, Tatiana Natasha.,Znaor, Ariana.,Zhang, Zuo-Feng.,Yu, Guo-Pei.,Winn, Deborah M..,...&Wuensch Filho, Victor.(2015).Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium.INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,44(1),169-185.
MLA Toporcov, Tatiana Natasha,et al."Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium".INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 44.1(2015):169-185.
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