学科主题公共卫生
Maternal Genetic Polymorphisms of Phase II Metabolic Enzymes and the Risk of Fetal Neural Tube Defects
Wang, Linlin; Jin, Lei; Liu, Jufen; Zhang, Yali; Yuan, Yue; Yi, Deqing; Ren, Aiguo
关键词indoor air pollution neural tube defects phase II metabolic enzymes single nucleotide polymorphism sulfotransferase
刊名BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
2014
DOI10.1002/bdra.23196
100期:1页:13-21
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Developmental Biology ; Toxicology
研究领域[WOS]Developmental Biology ; Toxicology
关键词[WOS]POLYCYCLIC AROMATIC-HYDROCARBONS ; CHINESE OCCUPATIONAL POPULATION ; SHANXI PROVINCE ; TRANSFERASE M1 ; CANCER-RISK ; SULT1A1 ; PHENOTYPE ; SULFOTRANSFERASES ; ASSOCIATION ; COMBUSTION
英文摘要

BackgroundMaternal exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with the risk of fetal neural tube defects (NTDs). Whether maternal genetic variants related to PAH metabolism contribute to the development of fetal NTDs remains unclear.

MethodsWe conducted a case-control study in a Chinese population to examine the association of selected maternal genetic variants of phase II enzymes involved in the elimination of the metabolic intermediates of these chemicals with fetal NTD risk, and to evaluate possible interaction of the genetic variant and maternal exposure to indoor air pollution from coal combustion and smoking (IAPCC). Blood samples were collected from 534 NTD case mothers and 534 control mothers and assayed for 12 polymorphisms of 5 genes encoding phase II enzymes.

ResultsWe found that the rs9282861 GG genotype of SULT1A1 was associated with an elevated risk of total NTDs (odds ratio [OR] = 2.12, 95% confidence interval [CI]: 1.49-3.00), compared with the GA genotype. The SULT1A1 rs9282861 variant showed a significant additive interaction with maternal exposure to IAPCC for NTD risk, with a relative excess risk of interaction of 1.20 (95% CI 0.23-2.18), and the OR for the joint effect of high-level IAPCC exposure and the GG genotype was 8.37 (95% CI: 3.63-19.28).

ConclusionMaternal SULT1A1 polymorphism is associated with the risk of fetal NTDs, and has an additive-scale interaction with maternal IAPCC exposure for NTD risk. Birth Defects Research (Part A) 100:13-21, 2014. (c) 2013 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000331064600003
项目编号31071315 ; 81202215
资助机构National Natural Science Foundation of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66846
专题北京大学公共卫生学院_北京大学生育健康研究所
作者单位1.Peking Univ, Inst Reprod & Child Hlth, Minist Hlth, Key Lab Reprod Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Linlin,Jin, Lei,Liu, Jufen,et al. Maternal Genetic Polymorphisms of Phase II Metabolic Enzymes and the Risk of Fetal Neural Tube Defects[J]. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY,2014,100(1):13-21.
APA Wang, Linlin.,Jin, Lei.,Liu, Jufen.,Zhang, Yali.,Yuan, Yue.,...&Ren, Aiguo.(2014).Maternal Genetic Polymorphisms of Phase II Metabolic Enzymes and the Risk of Fetal Neural Tube Defects.BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY,100(1),13-21.
MLA Wang, Linlin,et al."Maternal Genetic Polymorphisms of Phase II Metabolic Enzymes and the Risk of Fetal Neural Tube Defects".BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY 100.1(2014):13-21.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Linlin]的文章
[Jin, Lei]的文章
[Liu, Jufen]的文章
百度学术
百度学术中相似的文章
[Wang, Linlin]的文章
[Jin, Lei]的文章
[Liu, Jufen]的文章
必应学术
必应学术中相似的文章
[Wang, Linlin]的文章
[Jin, Lei]的文章
[Liu, Jufen]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。