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学科主题: 公共卫生
题名:
Maternal Genetic Polymorphisms of Phase II Metabolic Enzymes and the Risk of Fetal Neural Tube Defects
作者: Wang, Linlin; Jin, Lei; Liu, Jufen; Zhang, Yali; Yuan, Yue; Yi, Deqing; Ren, Aiguo
关键词: indoor air pollution ; neural tube defects ; phase II metabolic enzymes ; single nucleotide polymorphism ; sulfotransferase
刊名: BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
发表日期: 2014
DOI: 10.1002/bdra.23196
卷: 100, 期:1, 页:13-21
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Developmental Biology ; Toxicology
研究领域[WOS]: Developmental Biology ; Toxicology
关键词[WOS]: POLYCYCLIC AROMATIC-HYDROCARBONS ; CHINESE OCCUPATIONAL POPULATION ; SHANXI PROVINCE ; TRANSFERASE M1 ; CANCER-RISK ; SULT1A1 ; PHENOTYPE ; SULFOTRANSFERASES ; ASSOCIATION ; COMBUSTION
英文摘要:

BackgroundMaternal exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with the risk of fetal neural tube defects (NTDs). Whether maternal genetic variants related to PAH metabolism contribute to the development of fetal NTDs remains unclear.

MethodsWe conducted a case-control study in a Chinese population to examine the association of selected maternal genetic variants of phase II enzymes involved in the elimination of the metabolic intermediates of these chemicals with fetal NTD risk, and to evaluate possible interaction of the genetic variant and maternal exposure to indoor air pollution from coal combustion and smoking (IAPCC). Blood samples were collected from 534 NTD case mothers and 534 control mothers and assayed for 12 polymorphisms of 5 genes encoding phase II enzymes.

ResultsWe found that the rs9282861 GG genotype of SULT1A1 was associated with an elevated risk of total NTDs (odds ratio [OR] = 2.12, 95% confidence interval [CI]: 1.49-3.00), compared with the GA genotype. The SULT1A1 rs9282861 variant showed a significant additive interaction with maternal exposure to IAPCC for NTD risk, with a relative excess risk of interaction of 1.20 (95% CI 0.23-2.18), and the OR for the joint effect of high-level IAPCC exposure and the GG genotype was 8.37 (95% CI: 3.63-19.28).

ConclusionMaternal SULT1A1 polymorphism is associated with the risk of fetal NTDs, and has an additive-scale interaction with maternal IAPCC exposure for NTD risk. Birth Defects Research (Part A) 100:13-21, 2014. (c) 2013 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 31071315 ; 81202215
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000331064600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66846
Appears in Collections:北京大学公共卫生学院_北京大学生育健康研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Reprod & Child Hlth, Minist Hlth, Key Lab Reprod Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Linlin,Jin, Lei,Liu, Jufen,et al. Maternal Genetic Polymorphisms of Phase II Metabolic Enzymes and the Risk of Fetal Neural Tube Defects[J]. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY,2014,100(1):13-21.
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