IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
Biophysical studies on the differentiation of human CD14(+) mono cytes into dendritic cells
Zeng, Z; Liu, X; Jiang, YH; Wang, GT; Zhan, J; Guo, J; Yao, WJ; Sun, DG; Ka, W; Tang, Y; Tang, JM; Wen, ZY; Chien, S
关键词dendritic cell deformability membrane fluidity membrane viscoelastic properties osmotic fragility cytoskeleton
刊名CELL BIOCHEMISTRY AND BIOPHYSICS
2006
45期:1页:19-30
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]VISCOELASTIC PROPERTIES ; MATURATION ; MIGRATION ; CYTOSKELETON ; IMMUNOTHERAPY ; CHEMOKINES ; ORIGIN ; CANCER ; MODEL ; LONG
英文摘要

Dendritic cells (DCs), which are the most efficient antigen-presenting cells (APCs) currently known, can be derived from CD14(+) monocytes (DC predecessor cells) in vitro. Immature DCs actively take up antigens and pathogens, generate major histocompatability complex-peptide complexes, and migrate from the sites of antigen acquisition to secondary lymphoid organs to become mature dendritic cells that interact with and stimulate T-lymphocytes. During this process, the cells must undergo deformation to translocate through several barriers, including the basement membrane and interstitial connective tissue in the blood vessel wall. To further understand the mechanisms of the activation of immunological responses and the migration from peripheral tissue to secondary lymphoid organs, we have applied biophysical and microrheological methods to study the development processes of DCs in vitro. The results showed that membrane fluidity, osmotic fragility, membrane viscoelastic properties, infrared spectroscopy, and cytoskeleton organization of DCs exhibit significant differences in different developmental stages.

语种英语
WOS记录号WOS:000237404000002
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66849
专题北京大学基础医学院_生物物理学系
作者单位1.Peking Univ, Dept Biophys, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Med Phys, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat & Histol, Beijing 100871, Peoples R China
4.Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
5.Univ Calif San Diego, Whitaker Inst Biomed Engn, La Jolla, CA 92093 USA
推荐引用方式
GB/T 7714
Zeng, Z,Liu, X,Jiang, YH,et al. Biophysical studies on the differentiation of human CD14(+) mono cytes into dendritic cells[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2006,45(1):19-30.
APA Zeng, Z.,Liu, X.,Jiang, YH.,Wang, GT.,Zhan, J.,...&Chien, S.(2006).Biophysical studies on the differentiation of human CD14(+) mono cytes into dendritic cells.CELL BIOCHEMISTRY AND BIOPHYSICS,45(1),19-30.
MLA Zeng, Z,et al."Biophysical studies on the differentiation of human CD14(+) mono cytes into dendritic cells".CELL BIOCHEMISTRY AND BIOPHYSICS 45.1(2006):19-30.
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