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学科主题: 基础医学
题名:
Biophysical studies on the differentiation of human CD14(+) mono cytes into dendritic cells
作者: Zeng, Z; Liu, X; Jiang, YH; Wang, GT; Zhan, J; Guo, J; Yao, WJ; Sun, DG; Ka, W; Tang, Y; Tang, JM; Wen, ZY; Chien, S
关键词: dendritic cell ; deformability ; membrane fluidity ; membrane viscoelastic properties ; osmotic fragility ; cytoskeleton
刊名: CELL BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2006
卷: 45, 期:1, 页:19-30
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: VISCOELASTIC PROPERTIES ; MATURATION ; MIGRATION ; CYTOSKELETON ; IMMUNOTHERAPY ; CHEMOKINES ; ORIGIN ; CANCER ; MODEL ; LONG
英文摘要:

Dendritic cells (DCs), which are the most efficient antigen-presenting cells (APCs) currently known, can be derived from CD14(+) monocytes (DC predecessor cells) in vitro. Immature DCs actively take up antigens and pathogens, generate major histocompatability complex-peptide complexes, and migrate from the sites of antigen acquisition to secondary lymphoid organs to become mature dendritic cells that interact with and stimulate T-lymphocytes. During this process, the cells must undergo deformation to translocate through several barriers, including the basement membrane and interstitial connective tissue in the blood vessel wall. To further understand the mechanisms of the activation of immunological responses and the migration from peripheral tissue to secondary lymphoid organs, we have applied biophysical and microrheological methods to study the development processes of DCs in vitro. The results showed that membrane fluidity, osmotic fragility, membrane viscoelastic properties, infrared spectroscopy, and cytoskeleton organization of DCs exhibit significant differences in different developmental stages.

语种: 英语
WOS记录号: WOS:000237404000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66849
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Biophys, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Med Phys, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat & Histol, Beijing 100871, Peoples R China
4.Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
5.Univ Calif San Diego, Whitaker Inst Biomed Engn, La Jolla, CA 92093 USA

Recommended Citation:
Zeng, Z,Liu, X,Jiang, YH,et al. Biophysical studies on the differentiation of human CD14(+) mono cytes into dendritic cells[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2006,45(1):19-30.
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