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IR@PKUHSC  > 北京大学临床肿瘤学院  > 胸外科  > 期刊论文
学科主题: 临床医学
题名:
N-acetyltransferase 2 phenotype and risk of esophageal cancer: A meta analysis
作者: Ma, Ruo-Lan1,2; Min, Li3,4; Chen, Duo5; Tao, Wei-Ping1; Ge, Wei1; Wu, Yao-Gui1
关键词: N-acetyltransferase 2 ; esophageal cancer ; risk ; meta analysis
刊名: CANCER BIOMARKERS
发表日期: 2013
DOI: 10.3233/CBM-130387
卷: 13, 期:6, 页:447-455
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GENETIC POLYMORPHISMS ; LUNG-CANCER ; INDIAN POPULATION ; BLADDER-CANCER ; SUSCEPTIBILITY ; NAT2 ; N-ACETYLTRANSFERASE-2 ; ASSOCIATION ; EXPRESSION ; CARCINOMA
英文摘要:

N-acetyltransferase 2 (NAT2) gene encodes a phase II enzyme taking part in detoxification of aromatic amines. Published studies have demonstrated that N-Acetyltransferase 2 (NAT2) phenotype is a risk factor of various cancers. Many studies have investigated the association between NAT2 phenotype and susceptibility to esophageal cancer but yielded controversial results. To derive a more precise estimation of this association, a meta-analysis was performed. Electronic databases (Pubmed/Medline, ISI Web of Science and China National Knowledge Infrastructure) in English and Chinese were searched. A total of 5 articles including 476 cases and 1,093 controls were included in this meta-analysis. Odds ratio (OR) with 95% confidence interval (95% CI) was used to evaluate intensity of associations. Pooling studies together, NAT2 slow acetylator phenotype was a significant risk factor of esophageal squamous cell cancer (OR = 1.35, 95% CI = 1.03-1.77, n = 5 studies) but not esophageal adenocarcinoma (OR = 0.97, 95% CI = 0.47-2.04, n = 2 studies). There was a significant association between NAT2 acetylator phenotypes and ESCC in South Asian populations (OR = 1.51, 95% CI = 1.03-2.20), but not in East Asian populations (OR = 1.19, 95% CI = 0.80-1.77). Significant association between NAT2 acetylator phenotypes and esophageal cancer was found in population-based control subgroup (OR = 1.63, 95% CI = 1.07-2.50) but not in hospital-based control subgroup (OR = 1.19, 95% CI = 0.84-1.69). There is a significant association between NAT2 acetylator phenotype and esophageal cancer in both smokers (OR = 1.681, 95% CI = 1.179-2.395) and non-smokers (OR = 1.614, 95% CI = 1.173-2.222). In conclusion, NAT2 slow acetylator phenotype was a significant risk factor of ESCC in Asian populations.

语种: 英语
WOS记录号: WOS:000332476900007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66854
Appears in Collections:北京大学临床肿瘤学院_胸外科_期刊论文

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作者单位: 1.Wuhan Univ, Renmin Hosp, Ctr Oncol, Wuhan 430060, Hubei, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Thorac Surg 1, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Biochem, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Dept Mol Biol, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
5.Peking Univ, Canc Hosp & Inst, Dept Epidemiol, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China

Recommended Citation:
Ma, Ruo-Lan,Min, Li,Chen, Duo,et al. N-acetyltransferase 2 phenotype and risk of esophageal cancer: A meta analysis[J]. CANCER BIOMARKERS,2013,13(6):447-455.
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