北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 胸外科  > 期刊论文
学科主题: 临床医学
题名:
N-acetyltransferase 2 phenotype and risk of esophageal cancer: A meta analysis
作者: Ma, Ruo-Lan1,2; Min, Li3,4; Chen, Duo5; Tao, Wei-Ping1; Ge, Wei1; Wu, Yao-Gui1
关键词: N-acetyltransferase 2 ; esophageal cancer ; risk ; meta analysis
刊名: CANCER BIOMARKERS
发表日期: 2013
DOI: 10.3233/CBM-130387
卷: 13, 期:6, 页:447-455
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GENETIC POLYMORPHISMS ; LUNG-CANCER ; INDIAN POPULATION ; BLADDER-CANCER ; SUSCEPTIBILITY ; NAT2 ; N-ACETYLTRANSFERASE-2 ; ASSOCIATION ; EXPRESSION ; CARCINOMA
英文摘要:

N-acetyltransferase 2 (NAT2) gene encodes a phase II enzyme taking part in detoxification of aromatic amines. Published studies have demonstrated that N-Acetyltransferase 2 (NAT2) phenotype is a risk factor of various cancers. Many studies have investigated the association between NAT2 phenotype and susceptibility to esophageal cancer but yielded controversial results. To derive a more precise estimation of this association, a meta-analysis was performed. Electronic databases (Pubmed/Medline, ISI Web of Science and China National Knowledge Infrastructure) in English and Chinese were searched. A total of 5 articles including 476 cases and 1,093 controls were included in this meta-analysis. Odds ratio (OR) with 95% confidence interval (95% CI) was used to evaluate intensity of associations. Pooling studies together, NAT2 slow acetylator phenotype was a significant risk factor of esophageal squamous cell cancer (OR = 1.35, 95% CI = 1.03-1.77, n = 5 studies) but not esophageal adenocarcinoma (OR = 0.97, 95% CI = 0.47-2.04, n = 2 studies). There was a significant association between NAT2 acetylator phenotypes and ESCC in South Asian populations (OR = 1.51, 95% CI = 1.03-2.20), but not in East Asian populations (OR = 1.19, 95% CI = 0.80-1.77). Significant association between NAT2 acetylator phenotypes and esophageal cancer was found in population-based control subgroup (OR = 1.63, 95% CI = 1.07-2.50) but not in hospital-based control subgroup (OR = 1.19, 95% CI = 0.84-1.69). There is a significant association between NAT2 acetylator phenotype and esophageal cancer in both smokers (OR = 1.681, 95% CI = 1.179-2.395) and non-smokers (OR = 1.614, 95% CI = 1.173-2.222). In conclusion, NAT2 slow acetylator phenotype was a significant risk factor of ESCC in Asian populations.

语种: 英语
WOS记录号: WOS:000332476900007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66854
Appears in Collections:北京大学临床肿瘤学院_胸外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Wuhan Univ, Renmin Hosp, Ctr Oncol, Wuhan 430060, Hubei, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Thorac Surg 1, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Biochem, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Dept Mol Biol, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
5.Peking Univ, Canc Hosp & Inst, Dept Epidemiol, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China

Recommended Citation:
Ma, Ruo-Lan,Min, Li,Chen, Duo,et al. N-acetyltransferase 2 phenotype and risk of esophageal cancer: A meta analysis[J]. CANCER BIOMARKERS,2013,13(6):447-455.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ma, Ruo-Lan]'s Articles
[Min, Li]'s Articles
[Chen, Duo]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ma, Ruo-Lan]‘s Articles
[Min, Li]‘s Articles
[Chen, Duo]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace