IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity
Hida, K; Wada, J; Eguchi, J; Zhang, H; Baba, M; Seida, A; Hashimoto, L; Okada, T; Yasuhara, A; Nakatsuka, A; Shikata, K; Hourai, S; Futami, J; Watanabe, E; Matsuki, Y; Hiramatsu, R; Akagi, S; Makino, H; Kanwar, YS
关键词metabolic syndrome diabetes insulin resistance mesenteric white adipose tissue
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2005-07-26
DOI10.1073/pnas.0504703102
102期:30页:10610-10615
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]EXPANDING SUPERFAMILY ; OB/OB MICE ; RESISTANCE ; EXPRESSION ; DISEASE ; SERPINS ; GENOME ; MEN ; MECHANISM ; LEPTIN
英文摘要

There is a rapid global rise in obesity, and the link between obesity and diabetes remains somewhat obscure. We identified an adipocytokine, designated as visceral adipose tissue-derived serpin (vaspin), which is a member of serine protease inhibitor family. Vaspin cDNA was isolated by from visceral white adipose tissues (WATs) of Otsuka Long-Evans Tokushima fatty (OLETIF) rat, an animal model of abdominal obesity with type 2 diabetes. Rat, mouse, and human vaspins are made up of 392,394, and 395 amino acids, respectively; exhibit approximate to 40% homology with alpha(1)-antitrypsin; and are related to serine protease inhibitor family. Vaspin was barely detectable in rats at 6 wk and was highly expressed in adipocytes of visceral WATs at 30 wk, the age when obesity, body weight, and insulin levels peak in OLETF rats. The tissue expression of vaspin and its serum levels decrease with worsening of diabetes and body weight loss at 50 wk. The expression and serum levels were normalized with the treatment of insulin or insulin-sensitizing agent, pioglitazone, in OLETF rats. Administration of vaspin to obese CRL:CD-1 (ICR) (ICR) mice fed with high-fat high-sucrose chow improved glucose tolerance and insulin sensitivity reflected by normalized serum glucose levels. It also led to the reversal of altered expression of genes relevant to insulin resistance, e.g., leptin, resistin, TNF alpha, glucose transporter-4, and adiponectin. In DNA chip analyses, vaspin treatment resulted in the reversal of expression in approximate to 50% of the high-fat high-sucrose-induced genes in WATs. These findings indicate that vaspin exerts an insulin-sensitizing effect targeted toward WATs in states of obesity.

语种英语
WOS记录号WOS:000230853300038
引用统计
被引频次:399[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66856
专题北京大学第一临床医学院_肾脏内科
作者单位1.Sumitomo Pharmaceut Co Ltd, Takarazuka, Hyogo 6558555, Japan
2.Okayama Univ, Grad Sch Med & Dent, Dept Med & Clin Sci, Okayama 7008558, Japan
3.Peking Univ, Inst Nephrol, Dept Internal Med, Beijing 100034, Peoples R China
4.Sumitomo Chem Co Ltd, Environm Hlth Sci Lab, Osaka 5548558, Japan
5.Okayama Univ, Fac Engn, Dept Biosci & Biotechnol, Okayama 7008530, Japan
6.Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA
推荐引用方式
GB/T 7714
Hida, K,Wada, J,Eguchi, J,et al. Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2005,102(30):10610-10615.
APA Hida, K.,Wada, J.,Eguchi, J.,Zhang, H.,Baba, M.,...&Kanwar, YS.(2005).Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,102(30),10610-10615.
MLA Hida, K,et al."Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102.30(2005):10610-10615.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Hida, K]的文章
[Wada, J]的文章
[Eguchi, J]的文章
百度学术
百度学术中相似的文章
[Hida, K]的文章
[Wada, J]的文章
[Eguchi, J]的文章
必应学术
必应学术中相似的文章
[Hida, K]的文章
[Wada, J]的文章
[Eguchi, J]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。