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学科主题: 临床医学
题名:
Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity
作者: Hida, K; Wada, J; Eguchi, J; Zhang, H; Baba, M; Seida, A; Hashimoto, L; Okada, T; Yasuhara, A; Nakatsuka, A; Shikata, K; Hourai, S; Futami, J; Watanabe, E; Matsuki, Y; Hiramatsu, R; Akagi, S; Makino, H; Kanwar, YS
关键词: metabolic syndrome ; diabetes ; insulin resistance ; mesenteric ; white adipose tissue
刊名: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
发表日期: 2005-07-26
DOI: 10.1073/pnas.0504703102
卷: 102, 期:30, 页:10610-10615
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: EXPANDING SUPERFAMILY ; OB/OB MICE ; RESISTANCE ; EXPRESSION ; DISEASE ; SERPINS ; GENOME ; MEN ; MECHANISM ; LEPTIN
英文摘要:

There is a rapid global rise in obesity, and the link between obesity and diabetes remains somewhat obscure. We identified an adipocytokine, designated as visceral adipose tissue-derived serpin (vaspin), which is a member of serine protease inhibitor family. Vaspin cDNA was isolated by from visceral white adipose tissues (WATs) of Otsuka Long-Evans Tokushima fatty (OLETIF) rat, an animal model of abdominal obesity with type 2 diabetes. Rat, mouse, and human vaspins are made up of 392,394, and 395 amino acids, respectively; exhibit approximate to 40% homology with alpha(1)-antitrypsin; and are related to serine protease inhibitor family. Vaspin was barely detectable in rats at 6 wk and was highly expressed in adipocytes of visceral WATs at 30 wk, the age when obesity, body weight, and insulin levels peak in OLETF rats. The tissue expression of vaspin and its serum levels decrease with worsening of diabetes and body weight loss at 50 wk. The expression and serum levels were normalized with the treatment of insulin or insulin-sensitizing agent, pioglitazone, in OLETF rats. Administration of vaspin to obese CRL:CD-1 (ICR) (ICR) mice fed with high-fat high-sucrose chow improved glucose tolerance and insulin sensitivity reflected by normalized serum glucose levels. It also led to the reversal of altered expression of genes relevant to insulin resistance, e.g., leptin, resistin, TNF alpha, glucose transporter-4, and adiponectin. In DNA chip analyses, vaspin treatment resulted in the reversal of expression in approximate to 50% of the high-fat high-sucrose-induced genes in WATs. These findings indicate that vaspin exerts an insulin-sensitizing effect targeted toward WATs in states of obesity.

语种: 英语
WOS记录号: WOS:000230853300038
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66856
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Sumitomo Pharmaceut Co Ltd, Takarazuka, Hyogo 6558555, Japan
2.Okayama Univ, Grad Sch Med & Dent, Dept Med & Clin Sci, Okayama 7008558, Japan
3.Peking Univ, Inst Nephrol, Dept Internal Med, Beijing 100034, Peoples R China
4.Sumitomo Chem Co Ltd, Environm Hlth Sci Lab, Osaka 5548558, Japan
5.Okayama Univ, Fac Engn, Dept Biosci & Biotechnol, Okayama 7008530, Japan
6.Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA

Recommended Citation:
Hida, K,Wada, J,Eguchi, J,et al. Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2005,102(30):10610-10615.
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