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学科主题: 临床医学
题名:
Value-based medicine analysis on loop electrosurgical excision procedure and CO2 laser vaporization for the treatment of cervical intraepithelial neoplasia 2
作者: Sun, Lu-lu1; Cao, Dong-yan1; Yang, Jia-xin1; Bian, Mei-lu2; Wei, Li-hui3; Shen, Keng1
关键词: cervical intraepithelial neoplasia ; electrosurgery ; laser ; quality of life ; value-based medicine
刊名: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
发表日期: 2012-08-01
DOI: 10.1111/j.1447-0756.2011.01832.x
卷: 38, 期:8, 页:1064-1070
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: QUALITY-OF-LIFE ; CANCER ; MANAGEMENT ; WOMEN ; OUTCOMES ; LESIONS ; BIOPSY ; CIN
英文摘要:

Aim: The best treatment option for cervical intraepithelial neoplasia 2 (CIN2) is controversial and there is a lack of studies in value-based medicine. This multicenter comparative study was undertaken to evaluate the effectiveness, cost-effectives and quality of life (QOL) of loop electrosurgical excision procedure (LEEP) and CO2 laser vaporization for the treatment of CIN2. Material and Methods: A database of LEEP and laser vaporizations performed at three research centers was created. Patients with colposcopic-histopathologically confirmed CIN2 were randomly submitted to LEEP and laser vaporization. Cytology, human papilloma virus (HPV) DNA test and histology were performed, and a questionnaire on QOL was filled out during follow-up. Effectiveness, cost-effectives and QOL were analyzed. Results: Three hundred and thirty-eight women with CIN2 were included in the study. Frequencies of remission, and persistent and recurrent CIN were 89.2%, 7.2%, and 3.6% for LEEP, and 86.7%, 12.6%, 0.70% for laser, respectively. There was no significant difference in remission and persistence of CIN. There was a significant difference in the number of operations, recovery time and costs. Women treated with two methods showed relatively identical QOL. Conclusion: Both LEEP and CO2 laser vaporization are effective and reliable treatments for CIN2, whereas cervical tissue can be obtained for histology by LEEP. Preoperative evaluation and postoperative follow-up are important. Gynecologists should pay attention to QOL of patients with CIN.

语种: 英语
所属项目编号: D0906008040391
项目资助者: Technology Project Program of Beijing
WOS记录号: WOS:000306855900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66858
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Peking Union Med College, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, Beijing 100730, Peoples R China
2.Peking Univ, China Japan Friendship Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China

Recommended Citation:
Sun, Lu-lu,Cao, Dong-yan,Yang, Jia-xin,et al. Value-based medicine analysis on loop electrosurgical excision procedure and CO2 laser vaporization for the treatment of cervical intraepithelial neoplasia 2[J]. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH,2012,38(8):1064-1070.
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