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Single-Walled Carbon Nanohorns Inhibit Proliferation of Conjunctival Melanoma Cell Lines CRMM-1 and Involved in Energy Metabolism
Cao, Yongmei1; Zhang, Yan2; Zhao, Mingwei1
关键词Single-Walled Carbon Nanohorns (SWNHs) Conjunctival Melanoma Cell Proliferation Apoptosis
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
2015-02-01
DOI10.1166/jnn.2015.9092
15期:2页:1821-1830
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]MS/MS PROTEOME ANALYSIS ; HEPATOMA HEPG2 CELLS ; NAD(+) DEPLETION ; OXIDATIVE STRESS ; MACROPHAGE CELLS ; DRUG CARRIERS ; NANOTUBES ; ACTIVATION ; DEATH ; TUMOR
英文摘要

SWNHs induces accumulate with the levels of cytotoxic effects on different cell types and organs in animal models; it in a wide range may used for biomedical imaging. Conjunctival melanoma is a rare but potentially fatal ocular surface tumor. Recent studies of us have indicated the ability of SWNHs to inhibit proliferation of conjunctival melanoma cell line CRMM-1. But the role and molecular mechanisms of it was unclear. To address this question, the research about direct role of SWNHs on the growth, proliferation and apoptosis of CRMM-1 had been performed. Our results indicate that followed with the increasing concentrations of SWNHs, the number of cells decreased and apoptotic cells increased significantly. SWNHs delayed obviously mitotic entry of cells, and these effects followed the cultured time and the gradually increasing concentrations of SWNHs. SWNHs inhibited proliferation of cells at each time point in a time and dose-dependent manner, too. The TEM images showed that individual spherical SWNHs particles smaller than 100 nm in diameters were localized inside cytoplasma of cells. In summary, SWNHs inhibited mitotic entry, growth and proliferation of conjunctival melanoma cells and promoted its apoptosis, inhibited energy metabolism of cells in a dose-dependent manner. The roles of SWNHS on conjunctival melanoma cells were implicating energy metabolism. It may be the effective methods for treatment to conjunctival melanoma.

语种英语
WOS记录号WOS:000345054100141
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66860
专题北京大学第二临床医学院_眼科
作者单位1.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
2.Mil Gen Hosp Beijing PLA, Dept Ophthalmol, Beijing 100700, Peoples R China
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Cao, Yongmei,Zhang, Yan,Zhao, Mingwei. Single-Walled Carbon Nanohorns Inhibit Proliferation of Conjunctival Melanoma Cell Lines CRMM-1 and Involved in Energy Metabolism[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2015,15(2):1821-1830.
APA Cao, Yongmei,Zhang, Yan,&Zhao, Mingwei.(2015).Single-Walled Carbon Nanohorns Inhibit Proliferation of Conjunctival Melanoma Cell Lines CRMM-1 and Involved in Energy Metabolism.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,15(2),1821-1830.
MLA Cao, Yongmei,et al."Single-Walled Carbon Nanohorns Inhibit Proliferation of Conjunctival Melanoma Cell Lines CRMM-1 and Involved in Energy Metabolism".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15.2(2015):1821-1830.
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