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学科主题: 临床医学
题名:
Single-Walled Carbon Nanohorns Inhibit Proliferation of Conjunctival Melanoma Cell Lines CRMM-1 and Involved in Energy Metabolism
作者: Cao, Yongmei1; Zhang, Yan2; Zhao, Mingwei1
关键词: Single-Walled Carbon Nanohorns (SWNHs) ; Conjunctival Melanoma ; Cell Proliferation ; Apoptosis
刊名: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
发表日期: 2015-02-01
DOI: 10.1166/jnn.2015.9092
卷: 15, 期:2, 页:1821-1830
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: MS/MS PROTEOME ANALYSIS ; HEPATOMA HEPG2 CELLS ; NAD(+) DEPLETION ; OXIDATIVE STRESS ; MACROPHAGE CELLS ; DRUG CARRIERS ; NANOTUBES ; ACTIVATION ; DEATH ; TUMOR
英文摘要:

SWNHs induces accumulate with the levels of cytotoxic effects on different cell types and organs in animal models; it in a wide range may used for biomedical imaging. Conjunctival melanoma is a rare but potentially fatal ocular surface tumor. Recent studies of us have indicated the ability of SWNHs to inhibit proliferation of conjunctival melanoma cell line CRMM-1. But the role and molecular mechanisms of it was unclear. To address this question, the research about direct role of SWNHs on the growth, proliferation and apoptosis of CRMM-1 had been performed. Our results indicate that followed with the increasing concentrations of SWNHs, the number of cells decreased and apoptotic cells increased significantly. SWNHs delayed obviously mitotic entry of cells, and these effects followed the cultured time and the gradually increasing concentrations of SWNHs. SWNHs inhibited proliferation of cells at each time point in a time and dose-dependent manner, too. The TEM images showed that individual spherical SWNHs particles smaller than 100 nm in diameters were localized inside cytoplasma of cells. In summary, SWNHs inhibited mitotic entry, growth and proliferation of conjunctival melanoma cells and promoted its apoptosis, inhibited energy metabolism of cells in a dose-dependent manner. The roles of SWNHS on conjunctival melanoma cells were implicating energy metabolism. It may be the effective methods for treatment to conjunctival melanoma.

语种: 英语
所属项目编号: 20100501
项目资助者: Science and Technology Planning Project of Inner Mongolia, China
WOS记录号: WOS:000345054100141
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66860
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
2.Mil Gen Hosp Beijing PLA, Dept Ophthalmol, Beijing 100700, Peoples R China

Recommended Citation:
Cao, Yongmei,Zhang, Yan,Zhao, Mingwei. Single-Walled Carbon Nanohorns Inhibit Proliferation of Conjunctival Melanoma Cell Lines CRMM-1 and Involved in Energy Metabolism[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2015,15(2):1821-1830.
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