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学科主题: 临床医学
题名:
Determination of reference intervals for creatinine and evaluation of creatinine-based estimating equation for Chinese patients with chronic kidney disease
作者: Li, HaiXia1; Zhang, XuChu2; Xu, GuoBing1; Wang, XueJing1; Zhang, ChunLi2
关键词: Serum creatinine ; Reference intervals ; Chronic kidney disease ; MDRD equation ; Glomerular filtration rate
刊名: CLINICA CHIMICA ACTA
发表日期: 2009-05-01
DOI: 10.1016/j.cca.2009.01.019
卷: 403, 期:1-2, 页:87-91
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: GLOMERULAR-FILTRATION-RATE ; SERUM CREATININE ; RENAL-DISEASE ; PREDICTION EQUATION ; GAULT EQUATIONS ; CLEARANCE ; DIET ; MDRD ; POPULATION ; PREVALENCE
英文摘要:

Background: Several equations have been developed to estimate glomerular filtration rate (GFR). The aim of this study was to evaluate the performance of the three equations derived from Modification of Diet in Renal Disease (MDRD) formula: a-MDRD (original simplified), c-MDRD (modified with the Chinese coefficient), and j-MDRD (modified with the Japanese coefficient) in Chinese patients with chronic kidney disease (CKD). We also established the serum creatinine (Scr) reference intervals for Chinese healthy population.

Method: A total of 1132 healthy individuals and 283 CKD patients were enrolled in this study. Scr was measured by Jaffe kinetic method.

Results: The sex-related Scr reference intervals were 71-104 mu mol/l for males and 59-85 pmol/l for females. The c-MDRD equation overestimated reference GFR (rGFR) in CKD at stages 2, 3 and 4, but yielded lower bias over wide range of GFR. However, j-MDRD and a-MDRD resulted in a considerable bias. The j-MDRD equation was significantly lower than rGFR over wide range of GFR. a-MDRD and c-MDRD revealed similar accuracy, whereas j-MDRD produced lower accuracy than a-MDRD.

Conclusion: No racial differences in the Scr reference intervals were observed. The modified MDRD formulas based on data from Asian population do not significantly improve the accuracy and bias, as compared those of the original MDRD. Therefore, whether the original MDRD for GFR estimation needs to be modified by an ethnic factor requires further investigation and validation. (C) 2009 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000266190100014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66863
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100871, Peoples R China

Recommended Citation:
Li, HaiXia,Zhang, XuChu,Xu, GuoBing,et al. Determination of reference intervals for creatinine and evaluation of creatinine-based estimating equation for Chinese patients with chronic kidney disease[J]. CLINICA CHIMICA ACTA,2009,403(1-2):87-91.
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