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Determination of reference intervals for creatinine and evaluation of creatinine-based estimating equation for Chinese patients with chronic kidney disease
Li, HaiXia1; Zhang, XuChu2; Xu, GuoBing1; Wang, XueJing1; Zhang, ChunLi2
关键词Serum creatinine Reference intervals Chronic kidney disease MDRD equation Glomerular filtration rate
刊名CLINICA CHIMICA ACTA
2009-05-01
DOI10.1016/j.cca.2009.01.019
403期:1-2页:87-91
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]GLOMERULAR-FILTRATION-RATE ; SERUM CREATININE ; RENAL-DISEASE ; PREDICTION EQUATION ; GAULT EQUATIONS ; CLEARANCE ; DIET ; MDRD ; POPULATION ; PREVALENCE
英文摘要

Background: Several equations have been developed to estimate glomerular filtration rate (GFR). The aim of this study was to evaluate the performance of the three equations derived from Modification of Diet in Renal Disease (MDRD) formula: a-MDRD (original simplified), c-MDRD (modified with the Chinese coefficient), and j-MDRD (modified with the Japanese coefficient) in Chinese patients with chronic kidney disease (CKD). We also established the serum creatinine (Scr) reference intervals for Chinese healthy population.

Method: A total of 1132 healthy individuals and 283 CKD patients were enrolled in this study. Scr was measured by Jaffe kinetic method.

Results: The sex-related Scr reference intervals were 71-104 mu mol/l for males and 59-85 pmol/l for females. The c-MDRD equation overestimated reference GFR (rGFR) in CKD at stages 2, 3 and 4, but yielded lower bias over wide range of GFR. However, j-MDRD and a-MDRD resulted in a considerable bias. The j-MDRD equation was significantly lower than rGFR over wide range of GFR. a-MDRD and c-MDRD revealed similar accuracy, whereas j-MDRD produced lower accuracy than a-MDRD.

Conclusion: No racial differences in the Scr reference intervals were observed. The modified MDRD formulas based on data from Asian population do not significantly improve the accuracy and bias, as compared those of the original MDRD. Therefore, whether the original MDRD for GFR estimation needs to be modified by an ethnic factor requires further investigation and validation. (C) 2009 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000266190100014
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66863
专题北京大学第一临床医学院
北京大学第一临床医学院_核医学科
北京大学第一临床医学院_检验科
作者单位1.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, HaiXia,Zhang, XuChu,Xu, GuoBing,et al. Determination of reference intervals for creatinine and evaluation of creatinine-based estimating equation for Chinese patients with chronic kidney disease[J]. CLINICA CHIMICA ACTA,2009,403(1-2):87-91.
APA Li, HaiXia,Zhang, XuChu,Xu, GuoBing,Wang, XueJing,&Zhang, ChunLi.(2009).Determination of reference intervals for creatinine and evaluation of creatinine-based estimating equation for Chinese patients with chronic kidney disease.CLINICA CHIMICA ACTA,403(1-2),87-91.
MLA Li, HaiXia,et al."Determination of reference intervals for creatinine and evaluation of creatinine-based estimating equation for Chinese patients with chronic kidney disease".CLINICA CHIMICA ACTA 403.1-2(2009):87-91.
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