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学科主题: 临床医学
题名:
Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population
作者: Kong, Xianglei1,2,3,4,5; Ma, Yingchun1,2,3,4; Chen, Jianghua6; Luo, Qiong7; Yu, Xueqing8; Li, Ying9; Xu, Jinsheng10; Huang, Songmin11; Wang, Lining12; Huang, Wen13; Wang, Mei14; Xu, Guobin15; Zhang, Luxia1,2,3,4; Zuo, Li1,2,3,4; Wang, Haiyan1,2,3,4; Chinese EGFR Invest Collaboration
关键词: chronic kidney disease (CKD) ; eGFR equation ; glomerular filtration rate (GFR) ; Tc-99m-DTPA
刊名: NEPHROLOGY DIALYSIS TRANSPLANTATION
发表日期: 2013-03-01
DOI: 10.1093/ndt/gfs491
卷: 28, 期:3, 页:641-651
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Transplantation ; Urology & Nephrology
研究领域[WOS]: Transplantation ; Urology & Nephrology
关键词[WOS]: SERUM CREATININE ; RENAL-DISEASE ; GFR ; PREVALENCE ; CLEARANCE ; DIET
英文摘要:

Previous studies have indicated that the performance of glomerular filtration rate (GFR) estimation equations vary according to the races of the target population. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has not been validated in the Chinese population including patients with chronic kidney disease (CKD) and healthy controls.

A total of 977 adult persons (682 patients with CKD and 295 healthy volunteers) from nine renal institutes of university hospitals located in nine geographic regions of China were enrolled in the study. A diagnostic test study comparing the CKD-EPI two-level and four-level race equation, the Modification of Diet in Renal Disease (MDRD) Study equation and the modified MDRD equation for Chinese (the Chinese equation). The Tc-99m- diethylenetriamine pentaacetic acid dual plasma clearance was used as a reference method for measuring GFR.

The mean age of participants was 48.3 16.0 years and 479 (49.0) were male. The CKD-EPI two-level race equation and the Chinese equation performed better than the MDRD Study equation and CKD-EPI four-level race equation, with less bias (median difference between estimated GFR and reference GFR, 0.2 and 0.3 versus 2.4 and 3.0 mL/min/1.73 m(2)), improved precision (interquartile range of the difference, 20.5 and 20.8 versus 23.4 and 20.5 mL/min/1.73 m(2)) and greater accuracy (percentage of estimated GFR within 30 of reference GFR, 73.4 and 73.0 versus 69.8 and 70.1).

The CKD-EPI two-level race equation and the Chinese equation performed similarly in the Chinese population, and both performed better than the MDRD Study equation and the CKD-EPI four-level race equation.

语种: 英语
所属项目编号: 09050704310902 ; BMU2009131
项目资助者: Beijing Science and Technology Committee ; Program for New Century Excellent Talents in University from the Ministry of Education of the People&prime ; s Republic of China ; International Society of Nephrology Research Committee ; China Health and Medical Development Foundation
WOS记录号: WOS:000316120000021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66875
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.HeBei Med Med Univ, Dept Nephrol, Hosp 3, Shijia Zhuang, Peoples R China
4.Peking Univ, Dept Med, Renal Div, Hosp 1, Beijing 100871, Peoples R China
5.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100871, Peoples R China
6.Shandong Univ, Dept Nephrol, Qianfoshan Hosp, Jinan 250100, Peoples R China
7.ZheJang Med Coll, Hosp 1, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
8.Peking Univ, ShenZhen Hosp, Dept Nephrol, Shenzhen, Peoples R China
9.Sun Yat Sen Univ, Dept Nephrol, Hosp 1, Guangzhou 510275, Guangdong, Peoples R China
10.HeBei Med Med Univ, Hosp 4, Dept Nephrol, Shijia Zhuang, Peoples R China
11.Sichuan Univ, Dept Nephrol, Hua Xi Hosp, Chengdu 610064, Peoples R China
12.China Med Univ, Dept Nephrol, Hosp 1, Shenyang, Peoples R China
13.Capital Med Univ, Tong Ren Hosp, Dept Nephrol, Beijing, Peoples R China
14.Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100871, Peoples R China
15.Peking Univ, Dept Clin Lab, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Kong, Xianglei,Ma, Yingchun,Chen, Jianghua,et al. Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2013,28(3):641-651.
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