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Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population
Kong, Xianglei1,2,3,4,5; Ma, Yingchun1,2,3,4; Chen, Jianghua6; Luo, Qiong7; Yu, Xueqing8; Li, Ying9; Xu, Jinsheng10; Huang, Songmin11; Wang, Lining12; Huang, Wen13; Wang, Mei14; Xu, Guobin15; Zhang, Luxia1,2,3,4; Zuo, Li1,2,3,4; Wang, Haiyan1,2,3,4; Chinese EGFR Invest Collaboration
关键词chronic kidney disease (CKD) eGFR equation glomerular filtration rate (GFR) Tc-99m-DTPA
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2013-03-01
DOI10.1093/ndt/gfs491
28期:3页:641-651
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
研究领域[WOS]Transplantation ; Urology & Nephrology
关键词[WOS]SERUM CREATININE ; RENAL-DISEASE ; GFR ; PREVALENCE ; CLEARANCE ; DIET
英文摘要

Previous studies have indicated that the performance of glomerular filtration rate (GFR) estimation equations vary according to the races of the target population. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has not been validated in the Chinese population including patients with chronic kidney disease (CKD) and healthy controls.

A total of 977 adult persons (682 patients with CKD and 295 healthy volunteers) from nine renal institutes of university hospitals located in nine geographic regions of China were enrolled in the study. A diagnostic test study comparing the CKD-EPI two-level and four-level race equation, the Modification of Diet in Renal Disease (MDRD) Study equation and the modified MDRD equation for Chinese (the Chinese equation). The Tc-99m- diethylenetriamine pentaacetic acid dual plasma clearance was used as a reference method for measuring GFR.

The mean age of participants was 48.3 16.0 years and 479 (49.0) were male. The CKD-EPI two-level race equation and the Chinese equation performed better than the MDRD Study equation and CKD-EPI four-level race equation, with less bias (median difference between estimated GFR and reference GFR, 0.2 and 0.3 versus 2.4 and 3.0 mL/min/1.73 m(2)), improved precision (interquartile range of the difference, 20.5 and 20.8 versus 23.4 and 20.5 mL/min/1.73 m(2)) and greater accuracy (percentage of estimated GFR within 30 of reference GFR, 73.4 and 73.0 versus 69.8 and 70.1).

The CKD-EPI two-level race equation and the Chinese equation performed similarly in the Chinese population, and both performed better than the MDRD Study equation and the CKD-EPI four-level race equation.

语种英语
WOS记录号WOS:000316120000021
项目编号09050704310902 ; BMU2009131
资助机构Beijing Science and Technology Committee ; Program for New Century Excellent Talents in University from the Ministry of Education of the People&prime ; s Republic of China ; International Society of Nephrology Research Committee ; China Health and Medical Development Foundation
引用统计
被引频次:59[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66875
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.HeBei Med Med Univ, Dept Nephrol, Hosp 3, Shijia Zhuang, Peoples R China
4.Peking Univ, Dept Med, Renal Div, Hosp 1, Beijing 100871, Peoples R China
5.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100871, Peoples R China
6.Shandong Univ, Dept Nephrol, Qianfoshan Hosp, Jinan 250100, Peoples R China
7.ZheJang Med Coll, Hosp 1, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
8.Peking Univ, ShenZhen Hosp, Dept Nephrol, Shenzhen, Peoples R China
9.Sun Yat Sen Univ, Dept Nephrol, Hosp 1, Guangzhou 510275, Guangdong, Peoples R China
10.HeBei Med Med Univ, Hosp 4, Dept Nephrol, Shijia Zhuang, Peoples R China
11.Sichuan Univ, Dept Nephrol, Hua Xi Hosp, Chengdu 610064, Peoples R China
12.China Med Univ, Dept Nephrol, Hosp 1, Shenyang, Peoples R China
13.Capital Med Univ, Tong Ren Hosp, Dept Nephrol, Beijing, Peoples R China
14.Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100871, Peoples R China
15.Peking Univ, Dept Clin Lab, Hosp 1, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Kong, Xianglei,Ma, Yingchun,Chen, Jianghua,et al. Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2013,28(3):641-651.
APA Kong, Xianglei.,Ma, Yingchun.,Chen, Jianghua.,Luo, Qiong.,Yu, Xueqing.,...&Chinese EGFR Invest Collaboration.(2013).Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population.NEPHROLOGY DIALYSIS TRANSPLANTATION,28(3),641-651.
MLA Kong, Xianglei,et al."Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population".NEPHROLOGY DIALYSIS TRANSPLANTATION 28.3(2013):641-651.
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