|Effect of jianpiyiwei capsule on gastric precancerous lesions in rats|
|Shi, XY; Zhao, FZ; Dai, X; Ma, LS; Dong, XY; Fang, L|
|刊名||WORLD JOURNAL OF GASTROENTEROLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Gastroenterology & Hepatology|
|研究领域[WOS]||Gastroenterology & Hepatology|
|关键词[WOS]||HELICOBACTER-PYLORI ; STOMACH-CANCER ; RISK-FACTORS ; CARCINOGENESIS ; REFLUX ; DIET ; PROGRESSION ; POPULATION ; MUTATIONS ; CARCINOMA|
AIM:To evaluate the therapeutic effect of compound Chinese drugs, Jianpiyiwei capsule (JPYW) on gastric precancerous lesions in rats and to explore its mechanism of action.
METHODS:Model of gastric precancerous lesions was constructed in male Wistar rats: a metal spring was inserted and fixed through pyloric phincter. One week after recovery, each rat was given 50-60 degreesC hot paste containing 150 g/L NaCl 2 mL orally, twice a week for 15 weeks. Then 10 normal and 11 model rats were anaesthetized, after the measurement of gastric mucosa blood flow (GMBF), the rats were killed and the mucosal hexosamines and malonic dialdehyde (MDA) were measured. The morphological changes of gastric mucosa were observed macroscopically and microscopically, and by an automatic imaging analysis system. Other rats were treated with JPYW 1.5 g/kg(.)d(-1) or 4.5 g/kg(.)d(-1), or distilled water as negative control respectively (n=10 in each group). After 12 weeks, all the rats were examined as above.
RESULTS: The gastric mucosa of model rats showed chronic atrophic gastritis with dysplasia and intestinal metaplasia (IM), GMBF and hexosamine content were reduced significantly and MDA was increased as compared to the normal group (P<0.01). After 12 weeks treatment, the pathological changes of the negative control group became worsened, while in JPYW treated groups the changes were modified with significant increase of GMBF and reduction of MDA, although the hexosamine concentration increased only mildly.
CONCLUSION: JPYW increases GMBF and reduces MDA content in gastric mucosa and has therapeutic effects on gastric precancerous lesions.
|作者单位||1.Taiyuan Res & Treatment Ctr Digest Dis, Taiyuan 030001, Shanxi, Peoples R China|
2.Peking Univ, Dept Pathol, Sch Basic Med Sci, Beijing 100083, Peoples R China
3.Beijing Univ Tradit Chinese Med, Dept Pathol, Dongzhimen Affiliated Hosp, Beijing 100700, Peoples R China
4.Peking Univ, Sch Med Sci, Dept Gastroenterol, Sch Clin Med 3, Beijing 030001, Peoples R China
|Shi, XY,Zhao, FZ,Dai, X,et al. Effect of jianpiyiwei capsule on gastric precancerous lesions in rats[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2002,8(4):608-612.|
|APA||Shi, XY,Zhao, FZ,Dai, X,Ma, LS,Dong, XY,&Fang, L.(2002).Effect of jianpiyiwei capsule on gastric precancerous lesions in rats.WORLD JOURNAL OF GASTROENTEROLOGY,8(4),608-612.|
|MLA||Shi, XY,et al."Effect of jianpiyiwei capsule on gastric precancerous lesions in rats".WORLD JOURNAL OF GASTROENTEROLOGY 8.4(2002):608-612.|
|Effect of jianpiyiwe（1032KB）||期刊论文||出版稿||开放获取||CC BY-NC-SA||浏览 请求全文|