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学科主题基础医学
Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E
Hao, Jiaqing1; Song, Xiao1; Wang, Jingjing1; Guo, Chengli1; Li, Yan1; Li, Bing2; Zhang, Yu1; Yin, Yanhui1
关键词cancer-testis antigen MAGE-C2 SCF complex cyclin E cell cycle
刊名ONCOTARGET
2015-12-08
6期:39页:42028-42039
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Cell Biology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Oncology ; Cell Biology
关键词[WOS]RENAL-CELL CARCINOMA ; T-CELLS ; MELANOMA PATIENTS ; HEPATOCELLULAR-CARCINOMA ; BREAST-CANCER ; LUNG-CANCER ; EXPRESSION ; VACCINATION ; FAMILY ; DIFFERENTIATION
英文摘要

Cancer-testis antigen MAGE-C2 is normally expressed in testis but aberrantly expressed in various kinds of tumors. Its functions in tumor cells are mostly unknown. Here, we show that MAGE-C2 binds directly to the RING domain protein Rbx1, and participates in Skp1-Cullin1-F box protein (SCF) complex. Furthermore, MAGE-C2 can inhibit the E3 ubiquitin ligase activity of SCF complex. Ablation of endogenous MAGE-C2 decreases the level of cyclin E and accelerates cyclin E turnover by inhibiting ubiquitin-mediated proteasome degradation. Overexpression of MAGE-C2 increases the level of cyclin E and promotes G1-S transition and cell proliferation, and the results are further confirmed by knockdown of MAGE-C2. Overall, the study indicates that MAGE-C2 is involved in SCF complex and increases the stability of cyclin E in tumor cells.

语种英语
所属项目编号81071708 ; 81171974
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000366119600047
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66891
专题北京大学基础医学院_免疫学系
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Immunol, Beijing 100871, Peoples R China
2.Univ Louisville, Dept Microbiol & Immunol, Louisville, KY 40292 USA
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GB/T 7714
Hao, Jiaqing,Song, Xiao,Wang, Jingjing,et al. Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E[J]. ONCOTARGET,2015,6(39):42028-42039.
APA Hao, Jiaqing.,Song, Xiao.,Wang, Jingjing.,Guo, Chengli.,Li, Yan.,...&Yin, Yanhui.(2015).Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E.ONCOTARGET,6(39),42028-42039.
MLA Hao, Jiaqing,et al."Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E".ONCOTARGET 6.39(2015):42028-42039.
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