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学科主题: 临床医学
题名:
Complement in antineutrophil cytoplasmic antibody-associated vasculitis
作者: Yuan, Jun1,2,3,4,5,6,7; Chen, Min1,2,3,4,5; Zhao, Ming-Hui1,2,3,4,5
关键词: ANCA ; Vasculitis ; Complement
刊名: CLINICAL AND EXPERIMENTAL NEPHROLOGY
发表日期: 2013-10-01
DOI: 10.1007/s10157-012-0700-9
卷: 17, 期:5, 页:642-645
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ACTIVATION ; GLOMERULONEPHRITIS ; AUTOANTIBODIES ; NEUTROPHILS ; PATHOGENESIS ; RECEPTORS ; MICE ; C5A
英文摘要:

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a group of autoimmune disorders. It was previously assumed that the complement system is not involved in the development of ANCA-associated vasculitis due to its "pauci-immune" feature in renal histology. However, increasing evidence indicates that activation of the complement system, especially via the alternative complement pathway, plays a crucial role in the pathogenesis of ANCA-associated vasculitis. In this brief review, we discuss the evidence, including in vivo, in vitro, and clinical studies, for complement system activation in ANCA-associated vasculitis.

语种: 英语
所属项目编号: 2012CB517702 ; 2011BAI10B04 ; 30972733 ; 81021004
项目资助者: Chinese 973 project ; Ministry of Science and Technology of China ; National Natural Science Fund
WOS记录号: WOS:000325966600012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66892
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
4.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing 100034, Peoples R China
5.Peking Tsinghua Ctr Life Sci, Beijing 100034, Peoples R China
6.Hubei Univ Tradit Chinese Med, Wuhan 430061, Peoples R China
7.Hubei Hosp Tradit Chinese Med, Wuhan 430061, Peoples R China

Recommended Citation:
Yuan, Jun,Chen, Min,Zhao, Ming-Hui. Complement in antineutrophil cytoplasmic antibody-associated vasculitis[J]. CLINICAL AND EXPERIMENTAL NEPHROLOGY,2013,17(5):642-645.
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