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学科主题临床医学
Complement in antineutrophil cytoplasmic antibody-associated vasculitis
Yuan, Jun1,2,3,4,5,6,7; Chen, Min1,2,3,4,5; Zhao, Ming-Hui1,2,3,4,5
关键词ANCA Vasculitis Complement
刊名CLINICAL AND EXPERIMENTAL NEPHROLOGY
2013-10-01
DOI10.1007/s10157-012-0700-9
17期:5页:642-645
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者Chinese 973 project ; Ministry of Science and Technology of China ; National Natural Science Fund ; Chinese 973 project ; Ministry of Science and Technology of China ; National Natural Science Fund
研究领域[WOS]Urology & Nephrology
关键词[WOS]ACTIVATION ; GLOMERULONEPHRITIS ; AUTOANTIBODIES ; NEUTROPHILS ; PATHOGENESIS ; RECEPTORS ; MICE ; C5A
英文摘要

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a group of autoimmune disorders. It was previously assumed that the complement system is not involved in the development of ANCA-associated vasculitis due to its "pauci-immune" feature in renal histology. However, increasing evidence indicates that activation of the complement system, especially via the alternative complement pathway, plays a crucial role in the pathogenesis of ANCA-associated vasculitis. In this brief review, we discuss the evidence, including in vivo, in vitro, and clinical studies, for complement system activation in ANCA-associated vasculitis.

语种英语
所属项目编号2012CB517702 ; 2011BAI10B04 ; 30972733 ; 81021004
资助者Chinese 973 project ; Ministry of Science and Technology of China ; National Natural Science Fund ; Chinese 973 project ; Ministry of Science and Technology of China ; National Natural Science Fund
WOS记录号WOS:000325966600012
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66892
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
4.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing 100034, Peoples R China
5.Peking Tsinghua Ctr Life Sci, Beijing 100034, Peoples R China
6.Hubei Univ Tradit Chinese Med, Wuhan 430061, Peoples R China
7.Hubei Hosp Tradit Chinese Med, Wuhan 430061, Peoples R China
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Yuan, Jun,Chen, Min,Zhao, Ming-Hui. Complement in antineutrophil cytoplasmic antibody-associated vasculitis[J]. CLINICAL AND EXPERIMENTAL NEPHROLOGY,2013,17(5):642-645.
APA Yuan, Jun,Chen, Min,&Zhao, Ming-Hui.(2013).Complement in antineutrophil cytoplasmic antibody-associated vasculitis.CLINICAL AND EXPERIMENTAL NEPHROLOGY,17(5),642-645.
MLA Yuan, Jun,et al."Complement in antineutrophil cytoplasmic antibody-associated vasculitis".CLINICAL AND EXPERIMENTAL NEPHROLOGY 17.5(2013):642-645.
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