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学科主题: 临床医学
题名:
Effect of enalapril on plasma homocysteine levels in patients with essential hypertension
作者: Fan, Fang-fang1; Huo, Yong1; Wang, Xu2; Xu, Xin2; Wang, Bin-yan2; Xu, Xi-ping2; Li, Jian-ping1
关键词: Essential hypertension ; Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism ; Enalapril ; Homocysteine
刊名: JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
发表日期: 2010-08-01
DOI: 10.1631/jzus.B1001003
卷: 11, 期:8, 页:583-591
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: METHYLENETETRAHYDROFOLATE REDUCTASE GENE ; VASCULAR-DISEASE ; RISK-FACTOR ; MYOCARDIAL-INFARCTION ; CARDIOVASCULAR RISK ; C677T POLYMORPHISM ; STROKE PREVENTION ; COMMON MUTATION ; HEART-DISEASE ; INTERVENTION
英文摘要:

To investigate the effect of enalapril on plasma homocysteine (Hcy) levels and the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with the changes of Hcy levels in response to enalapril among patients with essential hypertension.

A total of 130 patients with mild-to-moderate essential hypertension were enrolled and enalapril was orally administered at a dose of 10 mg/d for eight weeks. Plasma Hcy levels were measured by denaturing high-performance liquid chromatography (DHPLC) at baseline and after eight weeks of treatment. Genotyping of MTHFR C677T polymorphism was performed by TaqMan probe technique.

Compared with baseline, plasma Hcy levels did not change significantly after eight weeks (P=0.81). Stratified by baseline Hcy levels, a significant increase in plasma Hcy levels (P=0.02) among those with Hcy < 10 mu mol/L was observed, in contrast to no significant changes in plasma Hcy levels (P=0.54) among those with Hcy a parts per thousand yen10 mu mol/L. No significant association was observed between MTHFR C677T polymorphism and changes in Hcy levels in response to enalapril.

Enalapril may cause an increase in plasma Hcy levels among the hypertensives with low baseline Hcy levels. There was no significant association between MTHFR C677T genotypes and changes in Hcy levels in response to enalapril among subjects with essential hypertension.

语种: 英语
WOS记录号: WOS:000280598600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66894
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Anhui Med Univ, Inst Biomed, Hefei 230032, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China

Recommended Citation:
Fan, Fang-fang,Huo, Yong,Wang, Xu,et al. Effect of enalapril on plasma homocysteine levels in patients with essential hypertension[J]. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,2010,11(8):583-591.
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