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学科主题: 临床医学
题名:
Probucol inhibits oxidized-low density lipoprotein- induced adhesion of monocytes to endothelial cells in vitro
作者: Liu, GX; Ou, DM; Li, LX; Chen, LX; Huang, HL; Liao, DF; Tang, CS
关键词: probucol ; LDL lipoproteins ; adhesions ; vascular endothelium ; cultured cells ; monocytes ; P-selectin ; E-selectin ; intercellular adhesion molecule-1 ; vascular cell adhesion molecule-1
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2002-06-01
卷: 23, 期:6, 页:516-522
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CORONARY ANGIOPLASTY ; NEOINTIMAL FORMATION ; LEUKOCYTE ADHESION ; BALLOON INJURY ; P-SELECTIN ; LDL ; ANTIOXIDANTS ; RESTENOSIS ; RABBIT ; ATHEROSCLEROSIS
英文摘要:

AIM: To investigate the mechanism by which probucol (PBC) affected adhesion of monocytes to human umbilical vein endothelial cells (HUVEC). METHODS: Effects of PBC on expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), P-selectin, and E-selectin in human umbilical vein endothelial cells were examined. Moreover, the inhibitory effect of PBC were compared with that of monoclonal antibodies (mAbs) to ICAM-1, VCAM-1, P-selectin, and E-selectin on adhesion induced by oxidized-low density lipoprotein ( Ox-LDL). RESULTS: PBC at 10 to 80 mumol/L inhibited Ox-LDL-induced adhesion index from 16.7 % to 7.0 % (P < 0.01) and Ox-LDL-induced expression of ICAM-1 (75 %) and P-selectin (72 %), mAbs to ICAM-1 or P-selectin, when used alone, could only slightly reduce die adhesion of monocyte to HUVEC. When both monoclonal antibodies were used in combination, the adhesion was markedly inhibited from 16.7 % to 11.3 % (P < 0.01), but the effect was still weaker than that of PBC (average 9.3 %). CONCLUSION: PBC exerts its inhibitory effect on the adhesion of monocyte to HUVEC by inhibiting the expression of ICAM-I and P-selectin.

语种: 英语
WOS记录号: WOS:000176101400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66895
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Nanhua Univ, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiovasc Res, Beijing 100034, Peoples R China

Recommended Citation:
Liu, GX,Ou, DM,Li, LX,et al. Probucol inhibits oxidized-low density lipoprotein- induced adhesion of monocytes to endothelial cells in vitro[J]. ACTA PHARMACOLOGICA SINICA,2002,23(6):516-522.
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