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学科主题: 临床医学
题名:
The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults
作者: Coppo, Rosanna1; Troyanov, Stephan2; Camilla, Roberta1; Hogg, Ronald J.3; Cattran, Daniel C.4; Cook, H. Terence5; Feehally, John6; Roberts, Ian S. D.7; Amore, Alessandro1; Alpers, Charles E.8; Barratt, Jonathan6; Berthoux, Francois9; Bonsib, Stephen10; Bruijn, Jan A.11; D′ Agati, Vivette12; D′ Amico, Giuseppe13; Emancipator, Steven N.14; Emma, Francesco15; Ferrario, Franco16; Fervenza, Fernando C.17; Florquin, Sandrine18; Fogo, Agnes B.19; Geddes, Colin C.20; Groene, Hermann J.21; Haas, Mark22; Herzenberg, Andrew M.23,24; Hill, Prue A.25; Hsu, Stephen I.26; Jennette, J. Charles27; Joh, Kensuke28; Julian, Bruce A.29; Kawamura, Tetsuya30; Lai, Fernand M.31; Li, Lei S.32; Li, Philip K.33; Liu, Zhi H.32; Mezzano, Sergio34; Schena, F. Paolo35; Tomino, Yasuhiko36; Walker, Patrick D.38; Wang, Haiyan37; Weening, Jan J.39; Yoshikawa, Norishige40; Zhang, Hong37; Int igA Nephropathy Network; Renal Pathology Soc
关键词: children ; histopathology ; IgA nephropathy ; renal biopsy
刊名: KIDNEY INTERNATIONAL
发表日期: 2010-05-01
DOI: 10.1038/ki.2010.43
卷: 77, 期:10, 页:921-927
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GLOMERULAR-FILTRATION-RATE ; PROGNOSTIC INDICATORS ; RENAL BIOPSIES ; FEATURES ; JAPANESE
英文摘要:

To study the predictive value of biopsy lesions in IgA nephropathy in a range of patient ages we retrospectively analyzed the cohort that was used to derive a new classification system for IgA nephropathy. A total of 206 adults and 59 children with proteinuria over 0.5 g/24h/1.73 m(2) and an eGFR of stage-3 or better were followed for a median of 69 months. At the time of biopsy, compared with adults children had a more frequent history of macroscopic hematuria, lower adjusted blood pressure, and higher eGFR but similar proteinuria. Although their outcome was similar to that of adults, children had received more immunosuppressants and achieved a lower follow-up proteinuria. Renal biopsies were scored for variables identified by an iterative process as reproducible and independent of other lesions. Compared with adults, children had significantly more mesangial and endocapillary hypercellularity, and less segmental glomerulosclerosis and tubulointerstitial damage, the four variables previously identified to predict outcome independent of clinical assessment. Despite these differences, our study found that the cross-sectional correlation between pathology and proteinuria was similar in adults and children. The predictive value of each specific lesion on the rate of decline of renal function or renal survival in IgA nephropathy was not different between children and adults. Kidney International (2010) 77, 921-927; doi: 10.1038/ki.2010.43; published online 3 March 2010

语种: 英语
WOS记录号: WOS:000277169800013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66898
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.San Carlo Borromeo Hosp, Renal Immunopathol Ctr, Milan, Italy
2.Mayo Clin, Div Nephrol & Hypertens, Rochester, MN USA
3.Vanderbilt Univ, Dept Pathol, Nashville, TN USA
4.Univ Hlth Network, Dept Pathol, Toronto, ON, Canada
5.Univ Toronto, Toronto, ON, Canada
6.St Vincents Hosp, Melbourne, Vic, Australia
7.E Natl Hosp, Div Immunopathol, Clin Res Ctr Chiba, Chiba, Japan
8.Wakayama Med Univ, Dept Pediat, Wakayama, Japan
9.Univ Bari, Renal Dialysis & Transplant Unit, Bari, Italy
10.Nephropathol Associates, Little Rock, AR USA
11.Erasmus MC, Rotterdam, Netherlands
12.Regina Margherita Childrens Hosp, Transplant Unit, I-10126 Turin, Italy
13.Jikei Univ, Div Nephrol & Hypertens, Sch Med, Tokyo, Japan
14.Univ London Imperial Coll Sci Technol & Med, Dept Histopathol, London, England
15.Leicester Gen Hosp, John Walls Renal Unit, Leicester LE5 4PW, Leics, England
16.John Radcliffe Hosp, Dept Cellular Pathol, Oxford OX3 9DU, England
17.Univ Washington, Med Ctr, Dept Pathol, Seattle, WA 98195 USA
18.CHU St Etienne, Dept Nephrol Dialysis & Transplantat, Hop Nord, St Etienne, France
19.LSU Hlth Sci Ctr, Dept Pathol, Shreveport, LA USA
20.Columbia Univ Coll Phys & Surg, Dept Pathol, New York, NY 10032 USA
21.Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
22.Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands
23.Univ Glasgow, Western Infirm, Renal Unit, Glasgow G11 6NT, Lanark, Scotland
24.German Canc Res Ctr, Dept Cellular & Mol Pathol, D-6900 Heidelberg, Germany
25.Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
26.Univ Florida, Coll Med, Div Nephrol Hypertens & Renal Transplantat, Gainesville, FL USA
27.Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA
28.Univ Alabama, Dept Med, Div Nephrol, Birmingham, AL 35294 USA
29.Chinese Univ Hong Kong, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
30.Nanjing Univ, Res Inst Nephrol, Jinling Hosp, Sch Med, Nanjing 210008, Peoples R China
31.Chinese Univ Hong Kong, Dept Med, Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China
32.Univ Austral Chile, Dept Nefrol, Escuela Med, Valdivia, Chile
33.Juntendo Univ, Sch Med, Div Nephrol, Dept Internal Med, Tokyo 113, Japan
34.Peking Univ, Div Renal, Hosp 1, Inst Nephrol, Beijing 100871, Peoples R China
35.Univ Montreal, Hop Sacre Coeur Montreal, Montreal, PQ, Canada
36.Scott & White Med Ctr, Temple, TX USA
37.Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON, Canada
38.Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands
39.Bambin Gesu Childrens Hosp, Rome, Italy
40.Fdn DAmico Ric Malattie Renali, Milan, Italy

Recommended Citation:
Coppo, Rosanna,Troyanov, Stephan,Camilla, Roberta,et al. The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults[J]. KIDNEY INTERNATIONAL,2010,77(10):921-927.
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