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学科主题基础医学
Elevation of NMDAR after transplantation of neural stem cells
Zhang, HQ; Lu, AL; Zhao, HG; Li, K; Song, SJ; Yan, J; Zhang, WW; Wang, SL; Li, LS
关键词cell transplantation cognition N-methyl-D-aspartate receptor neural stem cell senescence-accelerated mouse water maze
刊名NEUROREPORT
2004-08-06
DOI10.1097/01.wnr.0000131676.38437.2d
15期:11页:1739-1743
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]AGE-RELATED-CHANGES ; SENESCENCE-ACCELERATED MOUSE ; BRAIN-SLICES ; MEMORY ; RATS ; IMPAIRMENT ; EXPRESSION ; RECOVERY ; RELEASE ; GROWTH
英文摘要

Cognitive deficits could be alleviated by transplantation of neural stem cells in animals. Grafted cells may differentiate into neurons, thereby improving animal cognition. Alternatively, grafted cells may provide neurotrophic factors to modify neuronal functions and to alleviate cognitive deficits. To test which mechanism is underlying this recovery process, senescence-accelerated mice were transplanted with human neural stem cells into the hippocampus. The effect of cell transplantation was assessed in the Morris water maze. The survival and differentiation of grafted cells and the expression of NMDA receptors were examined. The data suggested that in addition to the neural differentiation of grafted neural stem cells, up-regulation of NMDA receptors after transplantation also contributed to the alleviation of cognitive deficits in this animal model.

语种英语
WOS记录号WOS:000225140800011
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66900
专题基础医学院_北京大学干细胞研究中心
作者单位Peking Univ, Stem Cell Res Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Zhang, HQ,Lu, AL,Zhao, HG,et al. Elevation of NMDAR after transplantation of neural stem cells[J]. NEUROREPORT,2004,15(11):1739-1743.
APA Zhang, HQ.,Lu, AL.,Zhao, HG.,Li, K.,Song, SJ.,...&Li, LS.(2004).Elevation of NMDAR after transplantation of neural stem cells.NEUROREPORT,15(11),1739-1743.
MLA Zhang, HQ,et al."Elevation of NMDAR after transplantation of neural stem cells".NEUROREPORT 15.11(2004):1739-1743.
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