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学科主题: 临床医学
题名:
MRI reveals changes in intracellular calcium in ischaemic areas of rabbit brain
作者: Zhang, F; Xie, J; Han, H
关键词: cerebral ischaemia ; calcium ; magnetic resonance imaging
刊名: NEURORADIOLOGY
发表日期: 2003-11-01
DOI: 10.1007/s00234-003-1001-5
卷: 45, 期:11, 页:773-779
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: FOCAL CEREBRAL-ISCHEMIA ; APPARENT DIFFUSION-COEFFICIENT ; RAT-BRAIN ; NEURONAL DEATH ; CELL-DEATH ; WATER ; PATHOPHYSIOLOGY ; PENUMBRA ; MODEL ; CAT
英文摘要:

Since calcium overload is thought to be important in ischaemic neuronal death, we have used a focal ischaemic model to determine the relationships between changes in intracellular calcium concentration ([Ca2+] (i)), apparent diffusion coefficient (ADC), and relative cerebral blood flow (rCBF). Focal cerebral ischaemia was induced in seven groups of six rabbits, by transorbital permanent occlusion of one middle cerebral artery (MCAo). Diffusion- and perfusion-weighted imaging was performed from 0.5 to 36 h after the occlusion. Brains were removed, and slices were taken. These slices were incubated with fluo-3 solution, and the fluorescent intensity (FI) of [Ca2+] (i) was viewed by confocal microscopy. There were significant differences in FI of Ca2+ between the ischaemic caudoputamen and the contralateral region in the seven groups of animals (F=24.34, P<0.001), while the difference between the ischaemic frontoparietal cortex and the contralateral region was not significant within 1.5 h of occlusion (F=1.06, P>0.05). Calcium overload occurred prior to an abrupt reduction in ADC in the peripheral ischaemic area. The relative ADC (rADC) and FI (rFI) were negatively correlated in the frontoparietal cortex (r=-0.9, P<0.001), but not in the caudoputamen (r=-0.21, P>0.05). Our findings suggest that ADC of the perifocal ischaemic area might reflect the changes in intracellular calcium which occur in early ischaemia. They may also suggest that, once the calcium level is high enough and infarction ensues, changes in ADC may not induce a further rise in calcium concentration.

语种: 英语
WOS记录号: WOS:000186517100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66907
Appears in Collections:北京大学第三临床医学院_放射科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, F,Xie, J,Han, H. MRI reveals changes in intracellular calcium in ischaemic areas of rabbit brain[J]. NEURORADIOLOGY,2003,45(11):773-779.
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