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MRI reveals changes in intracellular calcium in ischaemic areas of rabbit brain
Zhang, F; Xie, J; Han, H
关键词cerebral ischaemia calcium magnetic resonance imaging
刊名NEURORADIOLOGY
2003-11-01
DOI10.1007/s00234-003-1001-5
45期:11页:773-779
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]FOCAL CEREBRAL-ISCHEMIA ; APPARENT DIFFUSION-COEFFICIENT ; RAT-BRAIN ; NEURONAL DEATH ; CELL-DEATH ; WATER ; PATHOPHYSIOLOGY ; PENUMBRA ; MODEL ; CAT
英文摘要

Since calcium overload is thought to be important in ischaemic neuronal death, we have used a focal ischaemic model to determine the relationships between changes in intracellular calcium concentration ([Ca2+] (i)), apparent diffusion coefficient (ADC), and relative cerebral blood flow (rCBF). Focal cerebral ischaemia was induced in seven groups of six rabbits, by transorbital permanent occlusion of one middle cerebral artery (MCAo). Diffusion- and perfusion-weighted imaging was performed from 0.5 to 36 h after the occlusion. Brains were removed, and slices were taken. These slices were incubated with fluo-3 solution, and the fluorescent intensity (FI) of [Ca2+] (i) was viewed by confocal microscopy. There were significant differences in FI of Ca2+ between the ischaemic caudoputamen and the contralateral region in the seven groups of animals (F=24.34, P<0.001), while the difference between the ischaemic frontoparietal cortex and the contralateral region was not significant within 1.5 h of occlusion (F=1.06, P>0.05). Calcium overload occurred prior to an abrupt reduction in ADC in the peripheral ischaemic area. The relative ADC (rADC) and FI (rFI) were negatively correlated in the frontoparietal cortex (r=-0.9, P<0.001), but not in the caudoputamen (r=-0.21, P>0.05). Our findings suggest that ADC of the perifocal ischaemic area might reflect the changes in intracellular calcium which occur in early ischaemia. They may also suggest that, once the calcium level is high enough and infarction ensues, changes in ADC may not induce a further rise in calcium concentration.

语种英语
WOS记录号WOS:000186517100003
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66907
专题北京大学第三临床医学院_放射科
作者单位Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China
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Zhang, F,Xie, J,Han, H. MRI reveals changes in intracellular calcium in ischaemic areas of rabbit brain[J]. NEURORADIOLOGY,2003,45(11):773-779.
APA Zhang, F,Xie, J,&Han, H.(2003).MRI reveals changes in intracellular calcium in ischaemic areas of rabbit brain.NEURORADIOLOGY,45(11),773-779.
MLA Zhang, F,et al."MRI reveals changes in intracellular calcium in ischaemic areas of rabbit brain".NEURORADIOLOGY 45.11(2003):773-779.
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