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学科主题: 临床医学
题名:
Geldanamycin is effective in the treatment of herpes simplex virus epithelial keratitis in a rabbit model
作者: Wu, Xing1; Tao, Peizhen2,3; Nie, Hongping4
关键词: acyclovir ; geldanamycin ; herpes simplex virus type 1 ; rabbit model
刊名: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
发表日期: 2011-11-01
DOI: 10.1111/j.1442-9071.2011.02558.x
卷: 39, 期:8, 页:779-783
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: ACYCLOVIR ; CHAPERONE ; RESISTANCE ; HSP90
英文摘要:

Background: To evaluate the efficacy of geldanamycin eye drops against herpes simplex virus epithelial keratitis in a rabbit model.

Methods: New Zealand white rabbits were randomized into four groups and infected with herpes simplex virus type 1; geldanamycin topical eye drops was initiated 24 h after the infection and maintained for 12 consecutive days. Four groups of rabbits received 5 mu g/mL geldanamycin, 10 mu g/mL geldanamycin, 0.1% acyclovir and escipient (a kind of artificial tears), respectively. The severity of herpes simplex virus type 1 epithelial keratitis was measured by slit-lamp and scored for statistics analysis. The virus shedding in eye swabs was isolated, and tissue culture infective dose (TCID(50)) was determined.

Results: Geldanamycin (10 mu g/mL) treatment reduced significantly the severity of herpes simplex virus type 1 epithelial keratitis than the other three groups. Geldanamycin (5 mu g/mL) was as effective as acyclovir (0.1%) treatment. The effect of geldanamycin against herpes simplex virus type 1 epithelial keratitis correlated with accelerated clearance of virus of the rabbits.

Conclusion: Geldanamycin is a promising treatment option against herpes simplex virus type 1 epithelial keratitis. Geldanamycin (10 mu g/mL) is better than acyclovir and geldanamycin (5 mu g/mL) in the rabbit model. The optimal concentration of this drug in human is still to be determined.

语种: 英语
WOS记录号: WOS:000296913900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66908
Appears in Collections:北京大学第一临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Ophthalmol, Beijing, Peoples R China
2.Chinese Acad Med Sci, Chinese PLA Gen Hosp, Div Clin Surg, Dept Ophthalmol, Beijing 100853, Peoples R China
3.Chinese Acad Med Sci, Inst Med Biotechnol, Lab Antiviral Res, Beijing 100853, Peoples R China
4.Peking Union Med Coll, Beijing 100021, Peoples R China

Recommended Citation:
Wu, Xing,Tao, Peizhen,Nie, Hongping. Geldanamycin is effective in the treatment of herpes simplex virus epithelial keratitis in a rabbit model[J]. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2011,39(8):779-783.
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