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Geldanamycin is effective in the treatment of herpes simplex virus epithelial keratitis in a rabbit model
Wu, Xing1; Tao, Peizhen2,3; Nie, Hongping4
关键词acyclovir geldanamycin herpes simplex virus type 1 rabbit model
刊名CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
2011-11-01
DOI10.1111/j.1442-9071.2011.02558.x
39期:8页:779-783
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]ACYCLOVIR ; CHAPERONE ; RESISTANCE ; HSP90
英文摘要

Background: To evaluate the efficacy of geldanamycin eye drops against herpes simplex virus epithelial keratitis in a rabbit model.

Methods: New Zealand white rabbits were randomized into four groups and infected with herpes simplex virus type 1; geldanamycin topical eye drops was initiated 24 h after the infection and maintained for 12 consecutive days. Four groups of rabbits received 5 mu g/mL geldanamycin, 10 mu g/mL geldanamycin, 0.1% acyclovir and escipient (a kind of artificial tears), respectively. The severity of herpes simplex virus type 1 epithelial keratitis was measured by slit-lamp and scored for statistics analysis. The virus shedding in eye swabs was isolated, and tissue culture infective dose (TCID(50)) was determined.

Results: Geldanamycin (10 mu g/mL) treatment reduced significantly the severity of herpes simplex virus type 1 epithelial keratitis than the other three groups. Geldanamycin (5 mu g/mL) was as effective as acyclovir (0.1%) treatment. The effect of geldanamycin against herpes simplex virus type 1 epithelial keratitis correlated with accelerated clearance of virus of the rabbits.

Conclusion: Geldanamycin is a promising treatment option against herpes simplex virus type 1 epithelial keratitis. Geldanamycin (10 mu g/mL) is better than acyclovir and geldanamycin (5 mu g/mL) in the rabbit model. The optimal concentration of this drug in human is still to be determined.

语种英语
WOS记录号WOS:000296913900009
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66908
专题北京大学第一临床医学院_眼科
作者单位1.Peking Univ, Hosp 1, Dept Ophthalmol, Beijing, Peoples R China
2.Chinese Acad Med Sci, Chinese PLA Gen Hosp, Div Clin Surg, Dept Ophthalmol, Beijing 100853, Peoples R China
3.Chinese Acad Med Sci, Inst Med Biotechnol, Lab Antiviral Res, Beijing 100853, Peoples R China
4.Peking Union Med Coll, Beijing 100021, Peoples R China
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GB/T 7714
Wu, Xing,Tao, Peizhen,Nie, Hongping. Geldanamycin is effective in the treatment of herpes simplex virus epithelial keratitis in a rabbit model[J]. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2011,39(8):779-783.
APA Wu, Xing,Tao, Peizhen,&Nie, Hongping.(2011).Geldanamycin is effective in the treatment of herpes simplex virus epithelial keratitis in a rabbit model.CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,39(8),779-783.
MLA Wu, Xing,et al."Geldanamycin is effective in the treatment of herpes simplex virus epithelial keratitis in a rabbit model".CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 39.8(2011):779-783.
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