IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Elevation of Brain Magnesium Prevents and Reverses Cognitive Deficits and Synaptic Loss in Alzheimer′s Disease Mouse Model (Retracted article. See vol. 34, pg. 5733, 2014)
Li, Wei1; Yu, Jia2; Liu, Yong3; Huang, Xiaojie1; Abumaria, Nashat1; Zhu, Ying1; Huang, Xian1; Xiong, Wenxiang1; Ren, Chi1; Liu, Xian-Guo3; Chui, Dehua2; Liu, Guosong1,4
刊名JOURNAL OF NEUROSCIENCE
2013-05-08
DOI10.1523/JNEUROSCI.4610-12.2013
33期:19页:8423-8441
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NMDA RECEPTOR TRAFFICKING ; APP TRANSGENIC MICE ; MEMORY DEFICITS ; AMYLOID-BETA ; PLASTICITY ; CALCIUM ; DYSFUNCTION ; BACE1 ; NEUROPATHOLOGY ; TRANSMITTER
英文摘要

Profound synapse loss is one of the major pathological hallmarks associated with Alzheimer′s disease (AD) and might underlie memory impairment. Our previous work demonstrated that the magnesium ion is a critical factor in controlling synapse density/plasticity. Here, we investigated whether elevation of brain magnesium by the use of a recently developed compound, magnesium-L-threonate (MgT), can ameliorate the AD-like pathologies and cognitive deficits in the APPswe/PS1dE9 mice, a transgenic (Tg) mouse model of AD. MgT treatment reduced A beta plaque and prevented synapse loss and memory decline in the Tg mice. Strikingly, MgT treatment was effective even when given to the mice at the end stage of their AD-like pathological progression. To explore how elevation of brain magnesium ameliorates the AD-like pathologies in the brains of Tg mice, we studied molecules critical for APP metabolism and signaling pathways implicated in synaptic plasticity/density. In the Tg mice, the NMDAR/CREB/BDNF signaling was downregulated, whereas calpain/calcineurin/Cdk5 neurodegenerative signaling and beta-secretase (BACE1) expression were upregulated. MgT treatment prevented the impairment of these signaling pathways, stabilized BACE1 expression, and reduced soluble APP beta and beta-C-terminal fragments in the Tg mice. At the molecular level, elevation of extracellular magnesium prevented the high-A beta-induced reductions in synaptic NMDARs by preventing calcineurin overactivation in hippocampal slices. Correlation studies suggested that the protection of NMDAR signaling might underlie the stabilization of BACE1 expression. Our results suggest that elevation of brain magnesium exerts substantial synap-toprotective effects in a mouse model of AD and may have therapeutic potential for treating AD in humans.

语种英语
WOS记录号WOS:000318775200030
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66910
专题北京大学基础医学院_神经生物学系
作者单位1.Tsinghua Univ, Sch Med, Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100191, Peoples R China
3.Sun Yat Sen Univ, Zhongshan Sch Med, Dept Physiol, Guangzhou 510080, Guangdong, Peoples R China
4.Univ Texas Austin, Ctr Learning & Memory, Austin, TX 78712 USA
推荐引用方式
GB/T 7714
Li, Wei,Yu, Jia,Liu, Yong,等. Elevation of Brain Magnesium Prevents and Reverses Cognitive Deficits and Synaptic Loss in Alzheimer′s Disease Mouse Model (Retracted article. See vol. 34, pg. 5733, 2014)[J]. JOURNAL OF NEUROSCIENCE,2013,33(19):8423-8441.
APA Li, Wei.,Yu, Jia.,Liu, Yong.,Huang, Xiaojie.,Abumaria, Nashat.,...&Liu, Guosong.(2013).Elevation of Brain Magnesium Prevents and Reverses Cognitive Deficits and Synaptic Loss in Alzheimer′s Disease Mouse Model (Retracted article. See vol. 34, pg. 5733, 2014).JOURNAL OF NEUROSCIENCE,33(19),8423-8441.
MLA Li, Wei,et al."Elevation of Brain Magnesium Prevents and Reverses Cognitive Deficits and Synaptic Loss in Alzheimer′s Disease Mouse Model (Retracted article. See vol. 34, pg. 5733, 2014)".JOURNAL OF NEUROSCIENCE 33.19(2013):8423-8441.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Elevation of Brain M(5510KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Wei]的文章
[Yu, Jia]的文章
[Liu, Yong]的文章
百度学术
百度学术中相似的文章
[Li, Wei]的文章
[Yu, Jia]的文章
[Liu, Yong]的文章
必应学术
必应学术中相似的文章
[Li, Wei]的文章
[Yu, Jia]的文章
[Liu, Yong]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Elevation of Brain Magnesium Prevents and Reverses Cognitive Deficits and Synaptic Loss in Alzheimer′s Disease Mouse Model.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。