IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association
Hu, Jinsong1; Teng, Junlin1; Ding, Naizheng1; He, Mei1; Sun, Yuhui1; Yu, Albert Cheung Hoi3,4,5; Chen, Jianguo1,2
关键词D10Wsu52e gene FAAP cell adhesion vinculin paxillin FAK
刊名FRONTIERS IN BIOSCIENCE-LANDMARK
2008-05-01
DOI10.2741/3215
13页:7123-7131
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]FOCAL ADHESIONS ; KINASE ; MATRIX ; PHOSPHORYLATION ; EXPRESSION ; MIGRATION ; SRC ; LOCALIZATION ; APOPTOSIS ; DYNAMICS
英文摘要

Focal adhesion associated protein (FAAP), encoded by murine D10Wsu52e gene, is highly homologous to human HSPC117, which interacts with vinculin and talin. HeLa cells transfected with FAAP exhibited normal adhesion incorporation but showed impaired cell spreading, and restrained focal adhesion translocation. Moreover, FAAP facilitated vinculin-paxillin association, decreased interaction of paxillin-focal adhesion kinase and inhibited the phosphorylation of extracellular signal-regulated kinase. Together, these results suggest that FAAP, by virtue of modulating interaction of adhesion molecules, regulates cell adhesion dynamics.

语种英语
WOS记录号WOS:000255885000295
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66915
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 10083, Peoples R China
2.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China
3.Peking Univ, Dept Cell Biol & Genet, Key Lab Cell Proliferat & Differentiat, Coll Life Sci,Minist Educ, Beijing 100871, Peoples R China
4.Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 10083, Peoples R China
5.Peking Univ, Key Lab Neurosci, Minist Educ, Minist Publ Hlth, Beijing 10083, Peoples R China
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GB/T 7714
Hu, Jinsong,Teng, Junlin,Ding, Naizheng,et al. FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association[J]. FRONTIERS IN BIOSCIENCE-LANDMARK,2008,13:7123-7131.
APA Hu, Jinsong.,Teng, Junlin.,Ding, Naizheng.,He, Mei.,Sun, Yuhui.,...&Chen, Jianguo.(2008).FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association.FRONTIERS IN BIOSCIENCE-LANDMARK,13,7123-7131.
MLA Hu, Jinsong,et al."FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association".FRONTIERS IN BIOSCIENCE-LANDMARK 13(2008):7123-7131.
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