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学科主题: 基础医学
题名:
FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association
作者: Hu, Jinsong1; Teng, Junlin1; Ding, Naizheng1; He, Mei1; Sun, Yuhui1; Yu, Albert Cheung Hoi3,4,5; Chen, Jianguo1,2
关键词: D10Wsu52e gene ; FAAP ; cell adhesion ; vinculin ; paxillin ; FAK
刊名: FRONTIERS IN BIOSCIENCE-LANDMARK
发表日期: 2008-05-01
DOI: 10.2741/3215
卷: 13, 页:7123-7131
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: FOCAL ADHESIONS ; KINASE ; MATRIX ; PHOSPHORYLATION ; EXPRESSION ; MIGRATION ; SRC ; LOCALIZATION ; APOPTOSIS ; DYNAMICS
英文摘要:

Focal adhesion associated protein (FAAP), encoded by murine D10Wsu52e gene, is highly homologous to human HSPC117, which interacts with vinculin and talin. HeLa cells transfected with FAAP exhibited normal adhesion incorporation but showed impaired cell spreading, and restrained focal adhesion translocation. Moreover, FAAP facilitated vinculin-paxillin association, decreased interaction of paxillin-focal adhesion kinase and inhibited the phosphorylation of extracellular signal-regulated kinase. Together, these results suggest that FAAP, by virtue of modulating interaction of adhesion molecules, regulates cell adhesion dynamics.

语种: 英语
WOS记录号: WOS:000255885000295
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66915
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 10083, Peoples R China
2.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China
3.Peking Univ, Dept Cell Biol & Genet, Key Lab Cell Proliferat & Differentiat, Coll Life Sci,Minist Educ, Beijing 100871, Peoples R China
4.Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 10083, Peoples R China
5.Peking Univ, Key Lab Neurosci, Minist Educ, Minist Publ Hlth, Beijing 10083, Peoples R China

Recommended Citation:
Hu, Jinsong,Teng, Junlin,Ding, Naizheng,et al. FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association[J]. FRONTIERS IN BIOSCIENCE-LANDMARK,2008,13:7123-7131.
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