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Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population
Yu, Hao1,2; Bi, Wenjian3; Liu, Chenxing1,2; Zhao, Yanlong3; Zhang, Ji-Feng3; Zhang, Dai1,2,4,5; Yue, Weihua1,2
关键词Schizophrenia Genome-wide association study Protein-interaction-network-based analysis Susceptibility gene Pathway Network
刊名JOURNAL OF PSYCHIATRIC RESEARCH
2014-03-01
DOI10.1016/j.jpsychires.2013.11.014
50页:73-78
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
资助者National Natural Science Foundation of China ; Program for New Century Excellent Talents in University (NCET) ; National High Technology Research and Development ; International Science &amp ; Technology Cooperation Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University (NCET) ; National High Technology Research and Development ; International Science &amp ; Technology Cooperation Program of China
研究领域[WOS]Psychiatry
关键词[WOS]COMMON VARIANTS ; MISSING HERITABILITY ; BIPOLAR DISORDER ; CONFERRING RISK ; PATHWAYS ; DISEASES ; DIFFERENTIATION ; LOCI
英文摘要

Schizophrenia is a severe neuropsychiatric disorder with a strong and complex genetic background. Recent genome-wide association studies (GWAS) have successfully identified several susceptibility loci of schizophrenia. In order to interpret the functional role of the genetic variants and detect the combined effects of some of these genes on schizophrenia, protein-interaction-network-based analysis (PINBA) has emerged as an effective approach. In the current study, we conducted a PINBA of our previous GWAS data taken from the Han Chinese population. In order to do so, we used dense module search (DMS), a method that locates densely connected modules for complex diseases by integrating the association signal from GWAS datasets into the human protein protein interaction (PPI) network. As a result, we identified one gene set with a joint effect significantly associated with schizophrenia and gene expression profiling analysis suggested that they were mainly neuro- and immune-related genes, such as glutamatergic gene (GRM5), GABAergic genes (GABRB1, GABARAP) and genes located in the MHC region (HLA-C, TAP2, HIST1H1B). Further pathway enrichment analysis suggested that these genes are involved in processes related to neuronal and immune systems, such as the Adherens junction pathway, the Neurotrophin signaling pathway and the Toll-like receptor signaling pathway. In our study, we identified a set of susceptibility genes that had been missed in single-marker GWAS, and our findings could promote the study of the genetic mechanisms in schizophrenia. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

语种英语
所属项目编号81071087 ; 81222017 ; 11171333 ; 81221002 ; 61134013 ; 2009AA022702 ; 2010DFB30820
资助者National Natural Science Foundation of China ; Program for New Century Excellent Talents in University (NCET) ; National High Technology Research and Development ; International Science &amp ; Technology Cooperation Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University (NCET) ; National High Technology Research and Development ; International Science &amp ; Technology Cooperation Program of China
WOS记录号WOS:000331160800010
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66918
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
3.Peking Univ, Hosp 6, Inst Mental Hlth, Key Lab Mental Hlth,Minist Hlth, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
5.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yu, Hao,Bi, Wenjian,Liu, Chenxing,et al. Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2014,50:73-78.
APA Yu, Hao.,Bi, Wenjian.,Liu, Chenxing.,Zhao, Yanlong.,Zhang, Ji-Feng.,...&Yue, Weihua.(2014).Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population.JOURNAL OF PSYCHIATRIC RESEARCH,50,73-78.
MLA Yu, Hao,et al."Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population".JOURNAL OF PSYCHIATRIC RESEARCH 50(2014):73-78.
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